Yessotoxin analogues in several strains of Protoceratium reticulatum in Japan determined by liquid chromatography–hybrid triple quadrupole/linear ion trap mass spectrometry

Suzuki, Toshiyuki; Horie, Yoshifumi; Koike, Kazuo; Satake, Masayuki; Oshima, Yasukatsu; Iwataki, Mitsunori; Yoshimatsu, Sadaaki

doi:10.1016/j.chroma.2006.12.048

Cited by 46 publications

(32 citation statements)

References 40 publications

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“…Figure 17 shows linear ion trap LC-MS/MS spectra obtained for YTX (peak #4) and trinor-1-homoYTX (peak #3) detected in the P. reticulatum isolate extract. It is noteworthy that the LC-MS/MS spectrum obtained for YTX with a hybrid triple-quadrupole/linear ion trap mass spectrometer 101 was identical to that obtained by charge remote fragmentation FAB MS/MS analysis. 95 The MS/MS spectrum obtained for trinorYTX (peak #2) was identical to that obtained for YTX.…”

Section: Lc-ms/ms Of Yessotoxins (Ytxs)mentioning

confidence: 84%

“…Table 3 shows toxin content in several P. reticulatum strains by MRM LC-MS/MS analysis. 101 The toxin content and profile differed even among the strains collected in the same locations. Among strains producing YTX analogues, except for the strain collected from Ohmura, the most dominant toxin was YTX.…”

Section: Lc-ms/ms Of Yessotoxins (Ytxs)mentioning

confidence: 99%

“…73 Recently, a number of liquid chromatography-mass spectrometry (LC-MS) methods have been demonstrated as powerful tools for quantification of YTX analogues and structure elucidation of novel toxins in plankton and shellfish. 72,78,[80][81][82][83][84][85][86][87][88][89][90][91][96][97][98][99][100][101] A hybrid triple-quadrupole/linear ion trap MS/MS technique was proven to be useful for characterization of YTX analogues by our previous study. Figure 17 shows linear ion trap LC-MS/MS spectra obtained for YTX (peak #4) and trinor-1-homoYTX (peak #3) detected in the P. reticulatum isolate extract.…”

Section: Lc-ms/ms Of Yessotoxins (Ytxs)mentioning

confidence: 99%

See 2 more Smart Citations

LC-MS/MS Analysis of Diarrhetic Shellfish Poisoning (DSP) Toxins, Okadaic Acid and Dinophysistoxin Analogues, and Other Lipophilic Toxins

Suzuki

Quilliam

2011

ANAL. SCI.

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Section: Lc-ms/ms Of Yessotoxins (Ytxs)mentioning

confidence: 84%

Section: Lc-ms/ms Of Yessotoxins (Ytxs)mentioning

confidence: 99%

Section: Lc-ms/ms Of Yessotoxins (Ytxs)mentioning

confidence: 99%

See 1 more Smart Citation

LC-MS/MS Analysis of Diarrhetic Shellfish Poisoning (DSP) Toxins, Okadaic Acid and Dinophysistoxin Analogues, and Other Lipophilic Toxins

Suzuki

Quilliam

2011

ANAL. SCI.

Self Cite

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“…From about 100 known YTX analogues only 40% are characterized concerning their exact chemical structure (Miles et al, , 2005a(Miles et al, , 2005b(Miles et al, , 2006a(Miles et al, , 2006bPaz et al, 2008). Suzuki et al (2007) reported on P. reticulatum strains isolated at different sites of Japanese coasts (e.g. Mutsu Bay and Okirai Bay) which produced 45,46,, 1-homoyessotoxin (homo-YTX), 45,46,47-trinor-1-homoyessotoxin besides YTX.…”

Section: Introductionmentioning

confidence: 99%

Effects of salinity, temperature and nutrients on growth, cellular characteristics and yessotoxin production of Protoceratium reticulatum

Röder

Hantzsche²,

Gebühr

et al. 2012

Harmful Algae

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“…epidemiological studies, including case studies of intoxication incidences resulting from marine biotoxin exposure, are an undisputable requirement for a proper evaluation of the health risk associated with the exposure to marine biotoxins in fishery and aquaculture products. Rhodes et al, 2004;Samdal, 2005;Satake et al, 1997;Suzuki et al, 2007;Yasumoto, 2001;Aune et al, 2002;Draisci et al, 1999;tubaro et al, 2003;Rhodes et al, 2004).…”

Section: Epidemiology Of Marine Biotoxinsmentioning

confidence: 99%

A roadmap for hazard monitoring and risk assessment of marine biotoxins on the basis of chemical and biological test systems

Daneshian

2013

ALTEX

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Summary Aquatic food accounts for over 40% of global animal food products, and the potential contamination with toxins of algal origin -marine biotoxins -poses a health threat for consumers. The gold standards to assess toxins in aquatic food have traditionally been in vivo methodssingle marine biotoxins or combinations of marine biotoxins and intoxication symptomatology as well as monitoring the "success" of controls implemented during fishery and aquaculture production, processing, and retailing. For this reason, a workshop was organized in ermatingen, Switzerland by the Center for Alternatives to Animal testing -europe (CAAteurope) within the framework of the transatlantic think tank for toxicology (t 4 ).In contrast to other food products where hygiene and potential contamination with microbes or mold toxins is the prime issue, the emphasis in aquatic products (shellfish and finfish) is, beyond viral and bacterial contaminations, primarily placed on potential contamination with marine biotoxins owing to the numerous and recurring human intoxications.The gold standards to assess toxins in aquatic food have traditionally been in vivo methods, i.e., the mouse and the rat bioassays. Besides the ethical issues of in vivo bioassays there are specific difficulties, e.g., different exposure route (i.p. versus oral), low inter-species comparability, high intra-species variability, and questionable extrapolation of quantitative risk to humans, thus highlighting the need for the development of more reliable detection and quantification methods. Based on this reasoning, the european Food Safety Authority (eFSA) advocates the use of an analytical method, i.e., LC-MS (Liquid Chromatography coupled Mass Spectrometry), as a substitute for in vivo bioassays for almost all classes of marine toxins. However, although lC-MS is a very sensitive method that has the advantages of being able to detect multiple toxins in a single analysis and being good for confirming the identity of toxins, the quality of quantitative analysis is dependent on the availability of calibration standards. While many new toxin structural analogues have been detected and identified using LC-MS, this technique -as with most other methods -is not good at detecting new toxin types. When new toxin analogues are detected but accurate standards are not yet available, only an approximate quantitation is possible using estimated response factors.For the purpose of risk assessment of food, however, it is imperative to focus on the possible adverse effects, independent of whether they stem from one toxin or a combination of toxins. As toxicity is defined by functional and structural changes of biological systems, the development of a human-relevant in vitro system for appropriate risk assessment of marine biotoxins in seafood stands to reason. Moreover, poor correlation of human intoxications, of acute symptomatology and long-term adverse effects, and of predictive in vitro, in vivo, and analytical detection methodologies of marine biotoxins stems not least from a...

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Yessotoxin analogues in several strains of Protoceratium reticulatum in Japan determined by liquid chromatography–hybrid triple quadrupole/linear ion trap mass spectrometry

Cited by 46 publications

References 40 publications

LC-MS/MS Analysis of Diarrhetic Shellfish Poisoning (DSP) Toxins, Okadaic Acid and Dinophysistoxin Analogues, and Other Lipophilic Toxins

LC-MS/MS Analysis of Diarrhetic Shellfish Poisoning (DSP) Toxins, Okadaic Acid and Dinophysistoxin Analogues, and Other Lipophilic Toxins

Effects of salinity, temperature and nutrients on growth, cellular characteristics and yessotoxin production of Protoceratium reticulatum

A roadmap for hazard monitoring and risk assessment of marine biotoxins on the basis of chemical and biological test systems

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