Yersinia enterocolitica Lung Infection

Bigler, Robert D.

doi:10.1001/archinte.1981.00340120137029

Cited by 15 publications

(5 citation statements)

References 10 publications

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“…Indeed, the outbred strain of mice used here was more resistant to Y. pseudotuberculosis replication. It is noteworthy that experimentally induced pneumonia with aerosolized enteric Yersinia has been documented in several other mammals (20,82), and there are cases of the recovery of enteric Yersinia from the lungs of infected animals (7,12,50,60,61), although in such cases spread to the lungs most likely occurred after oral ingestion and subsequent systemic spread.…”

Section: Discussionmentioning

confidence: 99%

Intranasal Inoculation of Mice withYersinia pseudotuberculosisCauses a Lethal Lung Infection That Is Dependent onYersiniaOuter Proteins andPhoP

2007

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Section: Discussionmentioning

confidence: 99%

Intranasal Inoculation of Mice withYersinia pseudotuberculosisCauses a Lethal Lung Infection That Is Dependent onYersiniaOuter Proteins andPhoP

2007

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“…Septicemia caused by Y. enterocolitica traverses the spectrum of host health status and may occur in normal (37,80,128) and immunocompromised (142,159,177) hosts, as well as in those with an underlying disorder (37,48,80,159). The clinical course of Y. enterocolitica septicemia may include abscess formation in the liver and spleen (184), pneumonia (21,177,213), septic arthritis (111,216,228), meningitis and panophthalmitis (214), cellulitis (3), empyema (63), and osteomyelitis (203) and may evolve into endocarditis (7,237) or localize in the endovasculature of major blood vessels, leading to a mycotic aneurysm (176). Acquisition of the infecting strain may be via the oral route or associated with blood transfusion (217).…”

Section: Septicemiamentioning

confidence: 99%

Yersinia enterocolitica: the charisma continues

1997

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Yersinia enterocolitica, a gram-negative coccobacillus, comprises a heterogeneous group of bacterial strains recovered from animal and environmental reservoirs. The majority of human pathogenic strains are found among distinct serogroups (e.g. O:3, O:5,27, O:8, O:9) and contain both chromosome- and plasmid (60 to 75 kb)-mediated virulence factors that are absent in "avirulent" strains. While Y. enterocolitica is primarily a gastrointestinal tract pathogen, it may produce extraintestinal infections in hosts with underlying predisposing factors. Postinfection sequelae include arthritis and erythema nodosum, which are seen mainly in Europe among patients with serogroups O:3 and O:9 infection and HLA-B27 antigen. Y. enterocolitica is acquired through the oral route and is epidemiologically linked to porcine sources. Bacteremia is prominent in the setting of immunosuppression or in patients with iron overload or those being treated with desferrioxamine. metastatic foci following bacteremia are common and often involve the liver and spleen. Of particular concern is blood transfusion-related bacteremia. Evidence has accumulated substantiating the role of Y. enterocolitica as a food-borne pathogen that has caused six major outbreaks in the United States. The diagnosis of Y. enterocolitica gastroenteritis is best achieved through isolation of the bacterium on routine or selective bacteriologic media. When necessary, serogrouping, biogrouping, and assessment for plasmid-encoded virulence traits may aid in distinguishing virulent from "avirulent" strains. Epidemiologically, outside of identified food-borne outbreaks, the source (reservoir) of Y. enterocolitica in sporadic cases is speculative. Therefore, prevention and control measures are difficult to institute.

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“…56 Yersinia enterocolitica has been linked to lung infections in several case reports, with symptoms including pneumonia, lung abscesses, mediastinal adenopathy, and other lung diseases. 25,57,58 However, these findings have not been observed at the cohort level. At the molecular level, Yersinia enterocolitica infection has been shown to promote highly inflammatory responses by affecting T-cell function, 59,60 with IL-12 playing a role in preventing this.…”

Section: Discussionmentioning

confidence: 84%

“…23,24 Lung infections of Yersinia enterocolitica have been known for a long time, and it is a known bacteria that causes pneumonia. [25][26][27][28][29][30] Moraxella osloensis has also been found in the human respiratory tract and has been reported to cause severe pneumonia in lung cancer patients. [31][32][33][34] It was found more in normal tissues, but given that both samples were COPD lesion tissue and normal tissue from cancer patients, they could be sufficiently infected.…”

mentioning

confidence: 99%

Profiling of Microbial Landscape in Lung of Chronic Obstructive Pulmonary Disease Patients Using RNA Sequencing

Shin,

Kim,

Lee

et al. 2023

COPD

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The aim of the study was to use RNA sequencing (RNA-seq) data of lung from chronic obstructive pulmonary disease (COPD) patients to identify the bacteria that are most commonly detected. Additionally, the study sought to investigate the differences in these infections between normal lung tissues and those affected by COPD. Patients and Methods: We re-analyzed RNA-seq data of lung from 99 COPD patients and 93 non-COPD smokers to determine the extent to which the metagenomes differed between the two groups and to assess the reliability of the metagenomes. We used unmapped reads in the RNA-seq data that were not aligned to the human reference genome to identify more common infections in COPD patients. Results: We identified 18 bacteria that exhibited significant differences between the COPD and non-COPD smoker groups. Among these, Yersinia enterocolitica was found to be more than 30% more abundant in COPD. Additionally, we observed difference in detection rate based on smoking history. To ensure the accuracy of our findings and distinguish them from false positives, we doublecheck the metagenomic profile using Basic Local Alignment Search Tool (BLAST). We were able to identify and remove specific species that might have been misclassified as other species in Kraken2 but were actually Staphylococcus aureus, as identified by BLAST analysis. Conclusion:This study highlighted the method of using unmapped reads, which were not typically used in sequencing data, to identify microorganisms present in patients with lung diseases such as COPD. This method expanded our understanding of the microbial landscape in COPD and provided insights into the potential role of microorganisms in disease development and progression.

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Yersinia enterocolitica Lung Infection

Cited by 15 publications

References 10 publications

Intranasal Inoculation of Mice withYersinia pseudotuberculosisCauses a Lethal Lung Infection That Is Dependent onYersiniaOuter Proteins andPhoP

Intranasal Inoculation of Mice withYersinia pseudotuberculosisCauses a Lethal Lung Infection That Is Dependent onYersiniaOuter Proteins andPhoP

Yersinia enterocolitica: the charisma continues

Profiling of Microbial Landscape in Lung of Chronic Obstructive Pulmonary Disease Patients Using RNA Sequencing

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