Yerba mate aqueous extract improves the oxidative and inflammatory states of rats with adjuvant-induced arthritis

Corrêa, Vanesa Gesser; Sá‐Nakanishi, Anacharis Babeto de; Gonçalves, Geferson de Almeida; Barros, Lillian; Ferreira, Isabel C.F.R.; Bracht, Adelar

doi:10.1039/c9fo00491b

Cited by 18 publications

(8 citation statements)

References 42 publications

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“…Figure 4 illustrates the influence of arthritis and of the various treatments on several oxidative stress parameters in plasma. Confirming previous observations (Correa et al, 2019), the levels of protein carbonyls and plasma activity of myeloperoxidase were increased by arthritis. On the other hand, plasma content of thiol groups and plasma total antioxidant capacity (TAC -ABTS •+ scavenging capacity) were decreased.…”

Section: Plasma Oxidative Stress Parameterssupporting

confidence: 90%

Trans-anethole, the major constituent of the essential oil of anise, improves the antiarthritic effects of methotrexate in rats

Bonetti

Moreira

Rocha

et al. 2022

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The aim of this study was to evaluate the effect of trans-anethole in combination with methotrexate, compared to monotherapy with trans-anethole or methotrexate, on inflammatory parameters and oxidative stress of arthritic rats. The experimental model of arthritis induced by Freund's complete adjuvant (AIA) in rats was used. Treatment with trans-anethole and methotrexate, in combination or monotherapy, was started on the day of AIA induction and continued for 21 days. The association of anethole (62.5 mg/Kg) to methotrexate (6 mg/Kg) therapy was able to further reduce both the oxidative stress induced by arthritis and the inflammatory events that characterize the disease, as demonstrated by the following indicators: 1) decrease in the edema of the hind legs, in the score of secondary lesions, in the recruitment of leukocytes to the articular cavity and in the plasma myeloperoxidase activity; 2) increase in plasma content of reduced thiols and total antioxidant capacity; 3) diminution of protein carbonylation in plasma, liver and kidneys; 4) decrease in lipid peroxidation in the liver; 5) reduction in the hepatic ROS content; 6) enhancement of the activity of the antioxidant enzymes and GSH/GSSG ratio. In general, the combination anethole + methotrexate presented a substantially higher effect than the monotherapy with anethole or methotrexate (at the same doses). The data obtained in this work allow us to conclude that the use of trans-anethole in combination with methotrexate suppressed arthritic progression in rats, with the main advantage of reduction of methotrexate dose, attenuating adverse effects caused by high dose therapy.

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Section: Plasma Oxidative Stress Parameterssupporting

confidence: 90%

Trans-anethole, the major constituent of the essential oil of anise, improves the antiarthritic effects of methotrexate in rats

Bonetti

Moreira

Rocha

et al. 2022

RSD

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“…The beneficial effects of the applied treatment should be explained by the anti-inflammatory and antioxidant effects of Yerba Mate components (e.g., derivatives of chlorogenic acid). Hence, the conclusion that daily consumption of traditional Yerba Mate drinks may be effective in alleviating the symptoms of inflammatory diseases, especially in elderly people [79].…”

Section: Anti-inflammatory and Anti-cancer Effectsmentioning

confidence: 99%

Yerba Mate—A Long but Current History

2021

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Bearing in mind the growing interest in Yerba Mate, a comprehensive study has been prepared containing the most important aspects and possibilities of its use. The introduction of the work contains the species characteristics of Yerba Mate, as well as information about the origin and places of cultivation. The next part focuses on the analysis of the composition, pointing to purine alkaloids, polyphenols, saponins, and minerals as groups of active compounds responsible for the clinical activity of Yerba Mate. The review of the results of preclinical and clinical studies indicates activity in relation to the stimulating effect, reducing weight by stimulating lipolysis, cardioprotective, anti-diabetic, and anti-inflammatory effects. The information about the action of Yerba Mate is supplemented by the characteristics of its potential toxicity in terms of PAHs content (in particular benzo[α]pyrene) and preparation as a determinant of increased irritation. The current data on the effects of Yerba Mate and the wide safety margin of its use position this raw material as a valuable component of functional food. The growing frequency of consuming Yerba Mate, conditioned by the availability resulting from the globalization of the market and the information provided about it’s the pro-health effects, will position Yerba Mate's popularity among wider population groups.

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“…The microwave protected the degradation of these compounds when drying the leaf [43] by inactivating the enzyme to a potential oxidation. These compounds found in the extract have been reported to also present hepatoprotective [44] and anticancer [45] properties and attenuate symptoms of inflammatory diseases [46] which act through a mechanism known as oxidative stress [47].…”

Section: Yerba Mate Extract Release Antioxidant and Antibacterial Ana...mentioning

confidence: 99%

Yerba Mate Extract in Microfibrillated Cellulose and Corn Starch Films as a Potential Wound Healing Bandage

et al. 2020

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Microfibrillated cellulose films have been gathering considerable attention due to their high mechanical properties and cheap cost. Additionally, it is possible to include compounds within the fibrillated structure in order to confer desirable properties. Ilex paraguariensis A. St.-Hil, yerba mate leaf extract has been reported to possess a high quantity of caffeoylquinic acids that may be beneficial for other applications instead of its conventional use as a hot beverage. Therefore, we investigate the effect of blending yerba mate extract during and after defibrillation of Eucalyptus sp. bleached kraft paper by ultrafine grinding. Blending the extract during defibrillation increased the mechanical and thermal properties, besides being able to use the whole extract. Afterwards, this material was also investigated with high content loadings of starch and glycerine. The results present that yerba mate extract increases film resistance, and the defibrillated cellulose is able to protect the bioactive compounds from the extract. Additionally, the films present antibacterial activity against two known pathogens S. aureus and E. coli, with high antioxidant activity and increased cell proliferation. This was attributed to the bioactive compounds that presented faster in vitro wound healing, suggesting that microfibrillated cellulose (MFC) films containing extract of yerba mate can be a potential alternative as wound healing bandages.

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Yerba mate aqueous extract improves the oxidative and inflammatory states of rats with adjuvant-induced arthritis

Abstract: Healthy and adjuvant-induced arthritic rats were treated for 23 days with daily doses of 400 and 800 mg kg−1Ilex paraguariensis extract.

Cited by 18 publications

References 42 publications

Trans-anethole, the major constituent of the essential oil of anise, improves the antiarthritic effects of methotrexate in rats

Trans-anethole, the major constituent of the essential oil of anise, improves the antiarthritic effects of methotrexate in rats

Yerba Mate—A Long but Current History

Yerba Mate Extract in Microfibrillated Cellulose and Corn Starch Films as a Potential Wound Healing Bandage

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