Yellow nail syndrome: response to vitamin E

Ayres, S.

doi:10.1001/archderm.108.2.267

Cited by 21 publications

(15 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…'lteatment with vitamin E (d, a-tocopheryl acetate, 400 IU twice daily) has been reported to restore the nails to normal growth and colour and to relieve symptoms of lymphedema in one patient (19). Vitamin E caused partial improvement of the symptoms in another patient and had no effect in a third patient (18).…”

Section: General Therapymentioning

confidence: 99%

Yellow Nail Syndrome—the Triad of Yellow Nails, Lymphedema and Pleural Effusions

Nordkild

Kromann-Andersen

Struve-Christensen

1986

Journal of Internal Medicine

View full text Add to dashboard Cite

ABSTRACT. The yellow nail syndrome, combination of yellow discoloured nails, lymphedema and pleural effusions, is a rare clinical condition. A review of the literature, including 97 patients, is presented. Most patients developed yellow nail syndrome in early middle age, and the overall male: female ratio was 1: 1.6. The etiology of the syndrome is obscure, while the pathogenesis seems to involve impaired lymphatic drainage. A patient, whose recurrent pleural effusions were effectively controlled by chemical pleurodesis, is also presented.

show abstract

Section: General Therapymentioning

confidence: 99%

Yellow Nail Syndrome—the Triad of Yellow Nails, Lymphedema and Pleural Effusions

Nordkild

Kromann-Andersen

Struve-Christensen

1986

Journal of Internal Medicine

View full text Add to dashboard Cite

show abstract

“…Vitamin E [7], zinc [8], and topical corticosteroid plus active vitamin D3 [3] have been reported to be effective for treating yellow nails. Two cases of treating YNS with CAM have been described.…”

Section: Discussionmentioning

confidence: 99%

A Case of Yellow Nail Syndrome with Dramatically Improved Nail Discoloration by Oral Clarithromycin

Suzuki

Yoshizawa²,

Sugiyama³

et al. 2011

Case Rep Dermatol

View full text Add to dashboard Cite

An 80-year-old woman was admitted to our hospital with pneumonia and exacerbation of sinobronchial syndrome (SBS). She presented with yellow discoloration of the nail beds of all fingers and toes, and her nails were recognized as growing slowly. Chest X-ray revealed bronchiectasis in the bilateral lower lobe and bilateral pleural effusion. We diagnosed her as having yellow nail syndrome (YNS), based on the triad of yellow nails, lymphedema, and lung disease. After treatment with antibiotics [ampicillin/sulbactam and clarithromycin (CAM)] for pneumonia and SBS, her general condition improved, and the yellow nails disappeared in some fingers. When she was previously treated with 200 mg CAM for SBS, her yellow nails had not shown improvement. This time, her yellow nails improved after treatment with 400 mg CAM. The literature reports vitamin E, zinc, and topical corticosteroid plus active vitamin D3 to be effective in the treatment of yellow nails. Two studies have reported treatment for YNS using CAM, though they found a lack of efficacy. Thus, the present case is the first to report improved yellow nails using CAM alone. We conclude that not only SBS and lung disease but also YNS were improved by treatment with 400 mg CAM.

show abstract

“…(ii) Topical vitamin E applied twice daily to the nail plate, which may lead to marked clinical improvement, possibly mediated through increased nail growth rates 148 . Oral vitamin E up to 800 units per day for 12–18 months may be effective 149 . The response has been attributed to the scavenging effect on free radicals, protecting against lipid peroxidation and DNA damage.…”

Section: Widespread Nail Bed Insultsmentioning

confidence: 99%

Diseases of the generative nail apparatus. Part II: Nail bed

2002

View full text Add to dashboard Cite

Nail bed insults may affect the resultant nail product in a number of ways. If focal in nature, the severity and duration of the insult will determine the appearance of the nail product. Widespread insults may alter the size, shape or colour of the nail plate. Nail bed insults tend to present with more immediacy than nail matrical insults, as there is no need to wait until the nail grows out until the sign is obvious. We are less interested in the history of the event, than we are with the clinical sign being presented to us. Should treatment be required for focal nail bed insults, treatment is likely to be local and curative. Widespread nail bed insults may be associated with systemic diseases and if a result of local problems these may be difficult to treat.

show abstract

Yellow nail syndrome: response to vitamin E

Cited by 21 publications

References 0 publications

Yellow Nail Syndrome—the Triad of Yellow Nails, Lymphedema and Pleural Effusions

Yellow Nail Syndrome—the Triad of Yellow Nails, Lymphedema and Pleural Effusions

A Case of Yellow Nail Syndrome with Dramatically Improved Nail Discoloration by Oral Clarithromycin

Diseases of the generative nail apparatus. Part II: Nail bed

Contact Info

Product

Resources

About