Yeast species and biotypes associated with oral leukoplakia and lichen planus

Krogh, P.; Holmstrup, Palle; Thorn, Jens Jørgen; Vedtofte, Poul; Pindborg, J. J.

doi:10.1016/0030-4220(87)90339-2

Cited by 122 publications

(95 citation statements)

References 21 publications

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“…The overall incidence of C. albicans in the 102 culturepositive CRC samples was 87%. This high incidence of C. albicans relative to those of the other species concurs with most studies of the candidal epidemiology of the mouth (6,8). An interesting observation from the culture data was the apparent high incidence (compared with that in the healthy mouths) of Candida in oral conditions not primarily associated with the yeasts.…”

Section: Discussionsupporting

confidence: 86%

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Detection ofCandidain Concentrated Oral Rinse Cultures by Real-Time PCR

et al. 2004

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The incidence of oral candidosis has increased in recent years, largely as a result of the emergence of human immunodeficiency virus infection and the more widespread use of immunosuppressive chemotherapy. This development has been associated with a need for more reliable methods for the detection of Candida. The present study assessed the performance of a real-time PCR and two block-based PCRs for the detection of Candida in 193 concentrated oral rinse culture (CRC) specimens. A total of 102 CRC specimens were positive by culture for Candida; and 96, 90, and 75 of these were also positive by real-time, N18-specific, and internal transcribed spacer (ITS)-specific PCRs, respectively. The five false-negative results by the real-time PCR were all non-Candida albicans positive by culture. Of the 91 culture-negative CRC specimens, 20, 41, and 44 were positive by the real-time PCR and the N18-and ITS-specific PCRs, respectively. All three PCRs detected fungal DNA in 8 culture-negative CRC specimens, with a further 30 being positive by two of the three PCRs. A total of 32 CRC specimens were Candida free by all methods. In summary, a real-time PCR that provides a sensitive, specific, and rapid alternative technique for detection of Candida in the mouth is described.

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Section: Discussionsupporting

confidence: 86%

“…The significance of Candida in these cases is uncertain, but the altered oral state in these patients may, in part, offer an environment more favorable to candidal colonization. Similar high incidences of Candida from the mouths of individuals with leukoplakia (82%), lichen planus (47%), and burning mouth syndrome have been reported (6,7).…”

Section: Discussionsupporting

confidence: 72%

Detection ofCandidain Concentrated Oral Rinse Cultures by Real-Time PCR

et al. 2004

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“…In a similar study, candidal presence was found in 3 out of 30 cases (10%) using exfoliative cytology with PAS staining [6]. Other studies using non invasive techniques to estimate the presence of candidal hyphae in the oral cavity, other than exfoliative cytology included: Swab and culture method which yielded 90.1% [24] & 64% [25] yeasts & Rinse and culture method, which yielded 74.7% [7] & 75% [16] yeasts.…”

Section: Discussionmentioning

confidence: 99%

Correlation of Presence of Candida and Epithelial Dysplasia in Oral Mucosal Lesions

Singh

Gupta

Rajan

et al. 2014

JCDR

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AIMS AND OBJECTIVESThe aims of the study were to investigate the presence of Candidal organisms in oral mucosal lesions, by studying PAS stained cytosmear and histopathological sections of mucosal lesions. The Aim and Objective: The present study was designed to evaluate the correlation between presence of Candida organisms and epithelial dysplasia in various oral mucosal lesions associated with areca nut and tobacco use. Materials and Methods:A total of 50 individuals were selected, between age range of 19-70 y. Three separate cytosmears were prepared for each participant. All the slides were stained with PAS stain and the best slide was viewed for candidal organisms. Statistical Tests:The data was analysed using the SPSS version16. Chi square test was performed.

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“…3 These include high incidences of Candida in the mouth of patients with lichen planus, burning mouth syndrome, dry mouth, and leukoplakia. 3,4,5 The significance of Candida in these patients is uncertain, but it has been attracting increasing interest.…”

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confidence: 99%