Years lost due to disability from skin diseases in China 1990–2017: findings from the Global Burden of Disease Study 2017

Abstract

decrease in the yearly mortality rate during the study period: coefficient per quarter, SE = À0Á0081 AE 0Á0033 (95% CI À0Á015 to À0Á0011), P = 0Á025 (Fig. 1). Multivariate analyses confirmed this decrease: coefficient per quarter, SE = À0Á0089 AE 0Á0032 (95% CI À0Á016 to À0Á0017), P = 0Á020. In this cohort study, we found a significant decrease in mortality over 20 years in both univariate and multivariate analysis that was not explained by a modification in patients' profiles, including their severity, except for those receiving ciclosporin. Indeed, 118 patients (33%) received ciclosporin, mainly from 2005. A prospective short trial performed from 2005 to 2007 in our dermatology department suggested a mild benefit of ciclosporin on mortality and healing. 6 However, in a larger study using a propensity score methodology, including retrospectively all ciclosporin-treated patients at the same dermatology department from 2005 to 2016, the usefulness of ciclosporin could not be confirmed. 7 Thus, we hypothesize that the decrease in mortality in our centre is due to improved supportive care rather than ciclosporin treatment. 1,8 All of these measures were optimized by the creation of our reference centre in 2005 in the context of a national health policy for rare diseases, with implementation of a dedicated medical and paramedical team, a multidisciplinary approach to the acute phase and sequelae, teaching, and recently updated French guidelines. 8 We included in the multivariate analysis most of the variables associated with mortality, including ciclosporin treatment. However, a limitation of the study is the retrospective design, including the failure to take into account some other confounding factors. Mortality due to SJS, overlap syndrome and TEN has decreased over time in our centre. This could have resulted from a progressive improvement of supportive care.

Effect of seasonal change on the biomechanical and physical properties of the human skin

“…Also, 30% of skin disease patients have remarkable levels of psychological problems including social isolation, nervousness, anger, stress, depression, shame, low self-esteem, public embarrassment and impact on their sexual and career choices. Apart from personal lifestyle, social functioning and relationships, skin conditions also affect one's mental fitness [1][2][3]. Psycho dermatological findings show that 3% of dermatology patients live with a primary psychiatric disorder, while 85% of them expresses psychosocial comorbidities that influence their risks of depression, suicidal ideation, anxiety, career and leisure selections [4][5][6].…”

The Role of Type 2 Innate Lymphoid Cells in Allergic Diseases

“…Among those countries, the US had the highest incidence rate of severe AD. Dermatitis was reportedly one of the most significant causes of increased years lived with disability (YLD) values and the most prevalent skin condition in China in 2017, with 1.39 million cases being reported, which was increased by 5.05% compared with that in 1990 (1.32 million) ( 120 ).…”

A Dual-Modality Imaging Method Based on Polarimetry and Second Harmonic Generation for Characterization and Evaluation of Skin Tissue Structures

“…Skin diseases are prevalent and affect more than 30% of individuals worldwide [ 1 , 2 , 3 , 4 , 5 , 6 ]. During the development of skin diseases, structural changes in the different skin layers (stratum corneum, epidermis, dermis, and hypodermis) often occur [ 7 , 8 , 9 , 10 ].…”