Years in Review: Recent Progress in Cellular Allergology

Kratzer, Bernhard; Pickl, Winfried F.

doi:10.1159/000444753

Cited by 11 publications

(8 citation statements)

References 95 publications

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“…T helper cells are the main players in the allergic airway inflammatory response. CD4+ T cells are characterized by specific surface molecules expression and cytokine secretion profiles [ 11 ]. Th1 cells result from an IL-12 and IFN-γ driven polarization of naïve CD4+ T cells (Th0) towards a Th1 phenotype.…”

Section: Blood Cells In Armentioning

confidence: 99%

The impact of allergen exposure and specific immunotherapy on circulating blood cells in allergic rhinitis

Jordakieva

Jensen‐Jarolim²

2018

World Allergy Organization Journal

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Allergic rhinitis (AR) is an IgE-mediated inflammatory disease of the nasal mucosa with well described local immune responses during allergen exposure. The frequent association of AR with general extra-nasal symptoms and other allergic conditions, such as conjunctivitis and asthma, however, support a more systemic disease impact. In addition to acute elevation of soluble inflammatory mediators in periphery blood, a growing number of studies have reported changes in circulating blood cells after specific nasal allergen challenge or environmental allergen exposure. These findings imply an involvement of specific blood leukocyte subsets, thrombocytes and recently, erythrocytes. This review summarizes the circulating blood cell dynamics associated with allergen exposure in AR subjects reported so far. Additionally, the impact of therapy, particularly allergen-specific immunotherapy (AIT), the only currently available causal treatment reducing AR-related symptoms, is further considered in this context.

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Section: Blood Cells In Armentioning

confidence: 99%

The impact of allergen exposure and specific immunotherapy on circulating blood cells in allergic rhinitis

Jordakieva

Jensen‐Jarolim²

2018

World Allergy Organization Journal

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“…The LAD2 human MC line, as well as primary CBMC, express PKD protein constitutively, phosphorylated upon stimulation with T*m but not with Tm, thus supporting the validity of LAD2 as a human MC model [11,12]. FcεRI cross-linking stimulation of LAD2 human MC resulted in PKD phosphorylation as well (Fig.…”

Section: Discussionmentioning

confidence: 57%

The Involvement of Protein Kinase D in T Cell-Induced Mast Cell Activation

Salamon

Shefler

Hershko

et al. 2016

Int Arch Allergy Immunol

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Background: It has recently been reported that mast cells (MC) can be activated to degranulate and release certain cytokines in response to direct physical contact with activated but not resting T cells or their membranes. The MAPK family members ERK and p38 were found to participate. In this work, we further characterize the signaling events involved in this novel pathway of activation. Methods: Human MC were stimulated by activated T cell membranes (T*m). Phosphorylation of kinases was assessed by Western blotting. Protein kinase D (PKD) translocation was visualized by confocal microscopy. Degranulation was assessed by β-hexosaminidase release and cytokine production by ELISA. Results: Stimulation of human MC by activated T*m resulted in the activation of PKD. PKD inhibition by the specific pharmacological inhibitor Gö6976 resulted in a reduction in the phosphorylation of p38 but not ERK. Gö6976 also inhibited degranulation and cytokine release. Conclusions: MC stimulation by physical contact with T cells results in PKD activation, leading to the phosphorylation of p38, degranulation and release of cytokines. Understanding the molecular events associated with T cell-induced MC activation might lead to therapeutic approaches for controlling T cell-mediated inflammatory processes in which MC participate.

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“…В [10,13,[16][17][18]. Уровень IL-4 ИнМ у детей группы БА превышал таковой у детей группы сравнения как в начале (в 14,3 раза), так и в конце исследования (в 13,7 раза).…”

Section: результаты и обсуждениеunclassified

“…Уровень IL-4 ИнМ у детей группы БА превышал таковой у детей группы сравнения как в начале (в 14,3 раза), так и в конце исследования (в 13,7 раза). Следует отметить, что IL-4 является ростковым фактором B-клеток и переключает продукцию IgM на IgE, IgG4 [13,[17][18][19][20].…”

Section: результаты и обсуждениеunclassified

Persistence of the Eosinophilic Phenotype in Preschool Children with Mild Bronchial Asthma

Fedorov¹,

Rybakova²

2019

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Цель исследования: изучить в динамике особенности воспалительного фенотипа и цитоиммунологических показателей индуцированной мокроты (ИнМ) у детей дошкольного возраста с легкой персистирующей бронхиальной астмой (БА). Дизайн: проспективное когортное исследование. Материалы и методы. В течение 2 лет наблюдались 53 ребенка с легкой персистирующей БА в возрасте от 1,5 года до 5 лет (группа БА). Группу сравнения составили 20 детей того же возраста без аллергических заболеваний. В начале и в конце исследования было проведено определение уровней эозинофилов общего анализа крови, общего иммуноглобулина E крови, клеточного состава назального секрета (НС) и ИнМ, иммунологических факторов ИнМ. Результаты. У большинства детей с БА на всем протяжении исследования отмечались высокие уровни эозинофилов НС (≥ 5%) и эозинофилов ИнМ (≥ 2,5%). У 60% детей с БА в начале и в конце исследования преобладал эозинофильный воспалительный фенотип ИнМ, распространенность смешанного воспалительного фенотипа ИнМ к концу исследования статистически значимо не изменялась (р > 0,05). Уровни провоспалительных факторов ИнМ у детей с БА были статистически значимо (р < 0,05) выше, чем в группе сравнения, как в начале исследования, так и в период ремиссии БА. Заключение. Выявленные изменения свидетельствуют о наличии персистирующего воспаления при БА, которое сохраняется даже в период ремиссии легкой БА. Ключевые слова: дети, бронхиальная астма, индуцированная мокрота, эозинофилы, воспалительный фенотип.

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Years in Review: Recent Progress in Cellular Allergology

Cited by 11 publications

References 95 publications

The impact of allergen exposure and specific immunotherapy on circulating blood cells in allergic rhinitis

The impact of allergen exposure and specific immunotherapy on circulating blood cells in allergic rhinitis

The Involvement of Protein Kinase D in T Cell-Induced Mast Cell Activation

Persistence of the Eosinophilic Phenotype in Preschool Children with Mild Bronchial Asthma

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