The impact of allergen exposure and specific immunotherapy on circulating blood cells in allergic rhinitis

Jordakieva, Galateja; Jensen‐Jarolim, Erika

doi:10.1186/s40413-018-0197-0

Cited by 16 publications

(12 citation statements)

References 128 publications

(158 reference statements)

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“…In the literature, there are studies reporting different values of blood in both COPD [27][28][29] and allergic rhinitis cases [30,31] . In our study, creatinine and EOS were the highest in the group of patients diagnosed with COPD for the first time and diagnosed as allergic rhinitis.…”

Section: Discussionmentioning

confidence: 99%

Investigation of Chronic Obstructive Pulmonary Disease (COPD) Development in Terms of Urea, Creatinine and Some Blood Parameters in Patients with Allergic Rhinitis

Akduman

2019

ijirms

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Aim: In this retrospective crossectional study, it was aimed to evaluate the development of COPD in terms of urea, creatinine and some blood parameters in patients with allergic rhinitis. Method: Patients who were admitted to Kadıköy Medicana Hospital between 12.10.2017 and 12.10.2018 with respiratory complaints and has COPD diagnosis for the first time were evaluated retrospectively. Among the 845 patients admitted to the clinic for a one-year period, 160 patients with the diagnosis of COPD for the first time and 42 patients with a history of allergic rhinitis were subjected. The study group consisted of 63 patients with COPD who were diagnosed as COPD for the first time but without allergic rhinitis and 57 allergic rhinitis patients with no diagnosis of COPD. Findings: CRP, urea, WBC and neutrophil levels were higher in COPD group; creatinine and eisonofil levels were higher in COPD-Allergic rhinitis group and HGB was higher in the allergic rhinitis group. The differences between CRP and urea levels of COPD and allergic rhinitis group were statistically significant (p <0.05). The urea values were significantly different between COPD + allergic rhinitis and COPD groups (p <0.05). According to the results of ROC analysis, the value of urea for the COPD + allergic rhinitis group was statistically insignificant (p> 0.05), whereas it was statistically significant for the allergic rhinitis group (p <0.05). Conclusion: In detecting the difference between allergic rhinitis and COPD associated allergic rhinitis, urea levels may have a diagnostic value. An increase in urea in patients with allergic rhinitis may indicate comorbid COPD.

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Section: Discussionmentioning

confidence: 99%

Investigation of Chronic Obstructive Pulmonary Disease (COPD) Development in Terms of Urea, Creatinine and Some Blood Parameters in Patients with Allergic Rhinitis

Akduman

2019

ijirms

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“…The involvement of Th2 cytokines in AR has been widely investigated. The serum levels of Th2 cytokines including IL-4 and IL-13 are elevated in AR patients ( Jordakieva & Jensen-Jarolim, 2018 ). Increased expression of IL-4 in nasal epithelial cells of HDM-induced AR patients reduced ZO-1 mRNA expression ( Steelant et al, 2016 ).…”

Section: Survey Methodologymentioning

confidence: 99%

Zonula occludens and nasal epithelial barrier integrity in allergic rhinitis

Sarah

Shukri

Ashari

et al. 2020

PeerJ

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Allergic rhinitis (AR) is a common disease affecting 400 million of the population worldwide. Nasal epithelial cells form a barrier against the invasion of environmental pathogens. These nasal epithelial cells are connected together by tight junction (TJ) proteins including zonula occludens-1 (ZO-1), ZO-2 and ZO-3. Impairment of ZO proteins are observed in AR patients whereby dysfunction of ZOs allows allergens to pass the nasal passage into the subepithelium causing AR development. In this review, we discuss ZO proteins and their impairment leading to AR, regulation of their expression by Th1 cytokines (i.e., IL-2, TNF-α and IFN-γ), Th2 cytokines (i.e., IL-4 and IL-13) and histone deacetylases (i.e., HDAC1 and HDAC2). These findings are pivotal for future development of targeted therapies by restoring ZO protein expression and improving nasal epithelial barrier integrity in AR patients.

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“…Hypersensitivity type I reaction is associated with Th2 polarized lymphocyte response and involves production of IL-4, IL-5, and IL-13 cytokines and allergen-specific IgE antibodies. In particular, IL-4 and IL-13 regulate many aspects of allergic response, i.e., in B cells prompt the immunoglobulin switch to IgG1 and IgE, activate and recruit eosinophils and induce mucus hypersecretion in lung tissue (3). In respiratory allergies, nasal and lung epithelial cells are the first cells encountering allergen, such as house-dust mite faeces, fungal spores or plant pollen.…”

Section: Introductionmentioning

confidence: 99%

Viability Status-Dependent Effect of Bifidobacterium longum ssp. longum CCM 7952 on Prevention of Allergic Inflammation in Mouse Model

et al. 2021

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The classical definition of probiotics states that bacteria must be alive to be beneficial for human organism. However, recent reports show that inactivated bacteria or their effector molecules can also possess such properties. In this study, we investigated the physical and immunomodulatory properties of four Bifidobacterium strains in the heat-treated (HT) and untreated (UN) forms. We showed that temperature treatment of bacteria changes their size and charge, which affects their interaction with epithelial and immune cells. Based on the in vitro assays, we observed that all tested strains reduced the level of OVA-induced IL-4, IL-5, and IL-13 in the spleen culture of OVA-sensitized mice. We selected Bifidobacterium longum ssp. longum CCM 7952 (Bl 7952) for further analysis. In vivo experiments confirmed that untreated Bl 7952 exhibited allergy-reducing properties when administered intranasally to OVA-sensitized mice, which manifested in significant suppression of airway inflammation. Untreated Bl 7952 decreased local and systemic levels of Th2 related cytokines, OVA-specific IgE antibodies and simultaneously inhibited airway eosinophilia. In contrast, heat-treated Bl 7952 was only able to reduce IL-4 levels in the lungs and eosinophils in bronchoalveolar lavage, but increased neutrophil and macrophage numbers. We demonstrated that the viability status of Bl 7952 is a prerequisite for the beneficial effects of bacteria, and that heat treatment reduces but does not completely abolish these properties. Further research on bacterial effector molecules to elucidate the beneficial effects of probiotics in the prevention of allergic diseases is warranted.

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The impact of allergen exposure and specific immunotherapy on circulating blood cells in allergic rhinitis

Cited by 16 publications

References 128 publications

Investigation of Chronic Obstructive Pulmonary Disease (COPD) Development in Terms of Urea, Creatinine and Some Blood Parameters in Patients with Allergic Rhinitis

Investigation of Chronic Obstructive Pulmonary Disease (COPD) Development in Terms of Urea, Creatinine and Some Blood Parameters in Patients with Allergic Rhinitis

Zonula occludens and nasal epithelial barrier integrity in allergic rhinitis

Viability Status-Dependent Effect of Bifidobacterium longum ssp. longum CCM 7952 on Prevention of Allergic Inflammation in Mouse Model

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