We previously reported satisfactory results with the Karakoca resector balloon in 10 patients with stage IV chronic obstructive pulmonary disease (COPD) who did not respond to medical treatment. In this article, we present the outcomes of the Karakoca resector balloon dilatation and curettage technique in a larger case series (n = 188).A total of 188 COPD patients [mean age (SD): 69.2 (8.0) years; 46 females] classified as stage III to IV by the Global Initiative for Obstructive Lung Disease criteria underwent balloon desobstruction for segmental and subsegmental bronchi by therapeutic bronchoscopy. None of the patients could have achieved symptom relief even under high-dose inhaled bronchodilators and corticosteroids, oral corticosteroids, or oxygen and noninvasive mechanical ventilation therapy before the intervention. Forced expiratory volume in 1 s (FEV1) and oxygen saturation (SpO2) were measured, and modified Borg dyspnea scale (MBS) scores were determined before and 1 week and 1 month after the intervention.All patients were active smokers and 80% had concomitant chronic diseases. After the intervention, there was a notable reduction in the oxygen need of the patients. Comparison of lung function tests 1 week after the procedure with results before the procedure showed significant improvements in FEV1, MBS, and SpO2 levels (P < 0.001 for each), and the improvements were maintained for the entire postprocedural month (P < 0.001 for each). Except for 4 males, all patients were free of symptoms.These results confirmed our early observations that balloon dilatation and curettage is a safe and successful technique for medical treatment-resistant COPD.
The anatomic extent of disease, that is described by the TNM-classification remains the most important prognostic factor for lung cancer. Based on the changes in tumor characteristics, advances in diagnostic methods and treatment strategies, TNM-classifications are updated from time to time. The 7th TNM-classification was created on the basis of an international, large, and retrospective database. However due to retrospective data, there are still unanswered questions. Therefore "Prospective Lung Cancer Staging Project" is designed. In this project, in addition to the detailed evaluation of T, N, M descriptors; other factors, which were not considered to be relevant to lung cancer staging before, were also analyzed such as demographic data, histologic characteristics, certain biochemical and molecular prognostic and predictive factors. This project will be the basis of 8th TNM-classification for lung cancer. In this manuscript, we discuss the probable changes from the 7th TNM classification to the 8th.
Aim: In this retrospective crossectional study, it was aimed to evaluate the development of COPD in terms of urea, creatinine and some blood parameters in patients with allergic rhinitis. Method: Patients who were admitted to Kadıköy Medicana Hospital between 12.10.2017 and 12.10.2018 with respiratory complaints and has COPD diagnosis for the first time were evaluated retrospectively. Among the 845 patients admitted to the clinic for a one-year period, 160 patients with the diagnosis of COPD for the first time and 42 patients with a history of allergic rhinitis were subjected. The study group consisted of 63 patients with COPD who were diagnosed as COPD for the first time but without allergic rhinitis and 57 allergic rhinitis patients with no diagnosis of COPD. Findings: CRP, urea, WBC and neutrophil levels were higher in COPD group; creatinine and eisonofil levels were higher in COPD-Allergic rhinitis group and HGB was higher in the allergic rhinitis group. The differences between CRP and urea levels of COPD and allergic rhinitis group were statistically significant (p <0.05). The urea values were significantly different between COPD + allergic rhinitis and COPD groups (p <0.05). According to the results of ROC analysis, the value of urea for the COPD + allergic rhinitis group was statistically insignificant (p> 0.05), whereas it was statistically significant for the allergic rhinitis group (p <0.05). Conclusion: In detecting the difference between allergic rhinitis and COPD associated allergic rhinitis, urea levels may have a diagnostic value. An increase in urea in patients with allergic rhinitis may indicate comorbid COPD.
Aim: In this study, it was aimed to analyze the different clinical parameters according to gender and age for the first time in patients diagnosed with COPD. Methods: The study was designed retrospectively. Patients who were admitted to Kadikoy Medicana Hospital between 12.10.2017 and 12.10.2018 with respiratory complaints and COPD diagnosed for the first time were included in the study. A total of 160 patients with the diagnosis of COPD for the first time among 845 patients were included in the study. Age, gender, urea, creatinine, CRP, NEU, WBC, EOS and HGB values were obtained from the patient files. Findings: Clinical parameters of CRP, urea, creatinine, WBC, NEU and HGB were higher in male patients and EOS was higher in female patients. According to the results of the difference analysis, only HGB levels were statistically different between the groups (p <0.05). According to uncontrolled gender correlation analysis in patients with COPD for the first time, CRP (r = 0.224; p <0.01), urea (r = 0.580; p <0.01), creatinine (r = 0.331; p <0.01), creatinine (r = 0.331; p <0.01), EOS (r = -0.172; p<0.05) and HGB (r = -0.319; p <0.01) level correlations with age were statistically significant. There was a positive correlation between CRP, urea and creatinine and age, and there was a negative correlation between EOS and HGB and age. Age and urea (r = 0.573; p <0.01) and creatinine (r = 0.426; p <0.01) were statistically significant and positively correlated in women with firstly diagnosed COPD. Correlations between age and other research parameters were not statistically significant (p> 0.05). CRP (r = 0.300; p <0.01), urea (r = 0.565; p <0.01), creatinine (r = 295; p <0.05), creatinine (r = 295; p <0.05), EOS (r = -0.225; p <0.05) and HGB (r = -0.372; p <0.01) were significantly correlated in male patients who firstly diagnosed with COPD. The direction of the correlation was positive for CRP, urea and creatinine, and negative for EOS and HGB parameters. Conclusion: The results of the study show that age and urea and creatinine levels of the women with COPD diagnosis for the first time have changed according to age. In males, CRP, urea, creatinine, EOS and HGB values change according to age. Therefore, it is useful to study gender and age-related mechanisms in COPD.
This study aimed to investigate the diagnostic value of urea, Background: creatinine and other blood parameters in patients with pneumonia diagnosed with chronic obstructive pulmonary disease (COPD) for the first time.In this retrospective study, patients who had been diagnosed Methods: with COPD for the first time and were diagnosed with pneumonia were included. A total of 193 patients were divided into three groups as COPD + pneumonia (n=123), COPD (n=36) and pneumonia (n=34).In total, 59 women (48.0%) and 64 men (52.0%) from the COPD + Results: pneumonia group, 13 women (36.1%) and 23 men (63.9%) from the COPD group, 21 women (61.8%) and 13 men (38.2%) from the pneumonia group were assessed. The mean age of the COPD + pneumonia group was 69.58±13.62, 66.28±12.55 for the COPD group and 53.97±19.72 for the pneumonia group. The highest values of C-reactive protein (CRP), urea, creatinine, white blood cells (WBC), neutrophils, eosinophils and hemoglobin were the highest in COPD + pneumonia group. CRP levels were significantly different between COPD + pneumonia group (p<0.05). The parameters urea, WBC and neutrophils were significantly different between COPD + pneumonia group and pneumonia group (p<0.05). There was a statistically significant difference between COPD and pneumonia groups in terms of neutrophils and eosinophils values (p<0.05). According to the results of receiver operating characteristic analysis, the diagnostic value of the urea parameter in determining the COPD + pneumonia group was not statistically significant (p>0.05). On the other hand, the diagnostic value of CRP, WBC and neutrophils values were statistically significant (p<0.05).Elevation in WBC and neutrophil values in patients Conclusions: diagnosed with pneumonia have an important role in diagnosis of COPD.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.