Introduction: Yamaguchi Syndrome accounts for 15.0-25.0 % of all cases of hypertrophic cardiomyopathies in Japan. In addition, about 54.0 % of patients are symptomatic, including palpitations, dyspnoea, dizziness, syncope and chest pain. Objective: To present a special case of Apical Hypertrophic Cardiomyopathy (AHCM) in a female and Brazilian patient over eighty years old, as well as their recovery with pharmacological treatment. Highlight of Case: The present case report has its notorious importance due to its occurrence in patient without oriental descent; Longevity of the patient demonstrating the efficacy of pharmacological treatment; exhaustion of image evaluation methodologies for diagnosis and therapeutic conduction. Conclusion: The evolution of imaging diagnostic resources has made AHCM evaluation more elaborate, often providing information that helps therapeutical conduction, allowing an increase in survival with a significant improvement in quality of life.