A Novel Case of Yamaguchi Syndrome in a Hispanic Male

Shah, Farhan A; Fujikawa, Priscilla; Miller, Jeremy B; Singh, Harpal

doi:10.7759/cureus.17651

Cited by 6 publications

(11 citation statements)

References 13 publications

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“…As many as half of patients with ApHCM are mildly symptomatic or asymptomatic, and many patients have been diagnosed only when giant T wave inversions in the precordial leads are noted incidentally during electrocardiography. [ 5 6 7 ] Patients with ApHCM who are symptomatic may complain of chest pain, palpitation, dyspnoea, fatigue or syncope. Although severe clinical manifestations including sudden cardiac death, malignant arrhythmias, and apical infarction with apical aneurysm have been described, cardiovascular mortality is lower than in other variants of hypertrophic cardiomyopathies.…”

Section: Discussionmentioning

confidence: 99%

Yamaguchi syndrome

Ruhela

Ola

Chaturvedi

et al. 2022

Journal of Family Medicine and Primary Care

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Apical hypertrophic cardiomyopathy is a relatively rare subtype of hypertrophic cardiomyopathy with a wide range of clinical manifestation. The most frequent symptom is chest pain and thus it can mimic the acute coronary syndrome and due to unfamiliarity of this condition by some physicians, the diagnosis is frequently missed or delayed. In this case, report our purpose is to emphasize the importance of keeping apical hypertrophic cardiomyopathy as one of the differential diagnoses in a young patient presented with chest pain.

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Section: Discussionmentioning

confidence: 99%

Yamaguchi syndrome

Ruhela

Ola

Chaturvedi

et al. 2022

Journal of Family Medicine and Primary Care

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“…The disease is common in East Asian and was first reported in Japan in 1976 [1]. Although ApHCM has been well documented among other populations worldwide [2][3][4][5][6], to our knowledge, only one case has been reported among Hispanics [7].…”

Section: Discussionmentioning

confidence: 99%

Rare Occurrence of Apical Hypertrophic Cardiomyopathy Among Hispanics

et al. 2022

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Apical hypertrophic cardiomyopathy (ApHCM), also known as Yamaguchi syndrome represents an uncommon morphologic variant of hypertrophic cardiomyopathy (HCM) in which the myocardial hypertrophy predominantly involves the apex of the left ventricle (LV). It is exemplified by "giant" negative precordial T-waves on electrocardiography and a peculiar "spade-like" configuration of LV cavity on ventriculography historically, and more recently, on echocardiography with use of image enhancing agents. The disease entity was first described in 1976. Available literature reveals that it is prevalent largely among the East-Asian population but is rare among non-Asians. Here, we report a case of a 66-year-old Hispanic male with multiple cardiac histories including persistent atrial fibrillation, non-ST-elevation myocardial infarction (NSTEMI), and ventricular fibrillation cardiac arrest with multiple inconclusive evaluations, who later in life was found to have ApHCM. This case highlights the rare incidence of the disease among the Hispanic population and underlines the challenging diagnosis that requires a high index of suspicion in patients with cardiac symptoms, as ApHCM can masquerade as ischemic coronary heart disease. Our case also describes an unusual clinical course for ApHCM presenting with extreme clinical features, including ventricular arrhythmias and cardiac arrest, unlike the usual benign natural history of this disease.

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“…The hypertrophy mainly involves the apex of the left ventricle in the pure form of the disease, in case other segments of the heart are involved, the hypertrophy is classified as "mixed" [48]. Yamaguchi tends to occur more often in males and patients older than 40 years of age [49].…”

Section: Yamaguchi Syndromementioning

confidence: 99%

“…Patients exhibit symptoms that are similar to acute coronary syndrome (ACS), such as angina and dyspnea. They can also exhibit chest pain that worsens with movement and is relieved by rest, syncope, and palpitations [49]. According to Eriksson et al, in many patients, the presenting symptoms were those of the complications of the disease.…”

Section: Yamaguchi Syndromementioning

confidence: 99%

Broad Electrocardiogram Syndromes Spectrum: From Common Emergencies to Particular Electrical Heart Disorders

Balta

Ceasovschih

Șorodoc

et al. 2022

JPM

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Electrocardiogram (ECG) still remains a very useful diagnostic method in modern cardiology. Its broad availability, noninvasiveness and good sensitivity explain why it plays a capital role in the very beginning of the process of diagnosis for every patient, with or without cardiac-related complaints. For the practitioner, good training in ECG interpretation is mandatory. Sometimes, the ECG trace reveals particular aspects that may cause confusion and complicate decision-making. In this article, we present several less common situations underlying the general context and ECG features. The syndromes studied have a high pathological significance and may range from acute emergencies that call for a rapid therapeutical response to chronic syndromes that require prolonged observation, monitoring and risk stratification.

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A Novel Case of Yamaguchi Syndrome in a Hispanic Male

Cited by 6 publications

References 13 publications

Yamaguchi syndrome

Yamaguchi syndrome

Rare Occurrence of Apical Hypertrophic Cardiomyopathy Among Hispanics

Broad Electrocardiogram Syndromes Spectrum: From Common Emergencies to Particular Electrical Heart Disorders

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