Yamabushitake Mushroom (<i>Hericium erinaceus</i>) Improved Lipid Metabolism in Mice Fed a High-Fat Diet

Hiwatashi, Koichi; Kosaka, Yasuyuki; Suzuki, Norihiko; Hata, Keisuke; Mukaiyama, Toshiyuki; Sakamoto, Kenji; Shirakawa, Hitoshi; Komai, Michio

doi:10.1271/bbb.100130

Cited by 45 publications

(33 citation statements)

References 16 publications

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“…[1][2][3][4][5][6][7] Overnight fasting is generally applied in animal studies, 3,4,7) probably because it is recommended in medical examinations of humans. In these studies, fasting was started at light-off time of the day before the final day of the feeding.…”

Section: Discussionmentioning

confidence: 99%

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Impact of fasting time on hepatic lipid metabolism in nutritional animal studies

Ikeda

Metoki

Yamahira

et al. 2014

Bioscience, Biotechnology, and Biochemistry

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Many animal studies on improvement of lipid metabolism, using dietary components, fast the animals on the final day of the feeding. Although fasting has a significant impact on lipid metabolism, its time-dependent influence is not fully understood. We examined the effects of several fasting times on lipid metabolism. Rats fed with a semisynthetic diet for 2 wk were killed after 0 (9:00 am), 6 (7:00 am–1:00 pm), 9 (0:00 am–9:00 am), and 13 h (8:00 pm–9:00 am) of fasting. Compared to the 0 h group, marked reduction of liver weight and hepatic triacylglycerol content was observed in the 9 and 13 h groups. Activities of hepatic enzymes involved in fatty acid synthesis gradually decreased during fasting. In contrast, drastic time-dependent reduction of gene expression, of the enzymes, was observed. Expression of carnitine palmitoyltransferase mRNA was higher in the fasting groups than in the 0 h group. Our study showed that fasting has a significant impact on several parameters related to lipid metabolism in rat liver.

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Section: Discussionmentioning

confidence: 99%

“…[1][2][3][4][5][6][7] In these studies, researchers wanting to examine fasting parameters in serum, usually fast animals for a specific period on the final day of the feeding. The length of this fasting time varies from one study to another.…”

Section: Impact Of Fasting Time On Hepatic Lipid Metabolism In Nutritmentioning

confidence: 99%

Impact of fasting time on hepatic lipid metabolism in nutritional animal studies

Ikeda

Metoki

Yamahira

et al. 2014

Bioscience, Biotechnology, and Biochemistry

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“…After 1 wk of acclimatization, 7-wk-old female mice were divided randomly into 4 groups that were matched for body weight. Three groups of mice were fed a commercial HFD (HFD32, 56.7% calories from fat; CLEA Japan, Inc., Tokyo, Japan) for 4 wk to induce accumulation of visceral adipose tissue and insulin resistance as reported previously (6,7). Control mice were fed a commercial low-fat diet (LFD, 10.1% calories from fat; CLEA Japan, Inc.).…”

Section: Methodsmentioning

confidence: 99%

Trehalose Prevents Adipocyte Hypertrophy and Mitigates Insulin Resistance in Mice with Established Obesity

Arai

Miyake

Matsumoto

et al. 2013

J Nutr Sci Vitaminol

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Summary Our group recently demonstrated that simultaneous administration of trehalose with a high-fat diet (HFD) suppresses adipocyte hypertrophy and mitigates insulin resistance in mice. For the present study, we hypothesized that similar effects of trehalose would be observed in mice with previously-established obesity. Obese mice were fed a HFD and drinking water containing 0.3 or 2.5% (weight/volume) trehalose or distilled water (DW) ad libitum for 8 wk. After 7 wk intake of a HFD and trehalose, fasting serum insulin levels and homeostasis model assessment-insulin resistance (HOMA-IR) in the 0.3% Tre/ HFD group were significantly lower than those in the DW/HFD group (p,0.05). After 8 wk of treatment, mesenteric adipocytes in the 0.3% Tre/HFD group showed significantly less hypertrophy than those in the DW/HFD group. Mechanistic analysis indicated that levels of high molecular weight (HMW) adiponectin in the serum of the 0.3% Tre/HFD group were significantly higher than those in the DW/HFD group. The expression levels of insulin receptor substrate-1 (IRS-1) and insulin receptor substrate-2 (IRS-2) messenger RNA (mRNA) in muscle were also significantly increased by trehalose intake. Our data therefore suggest that administration of trehalose to obese mice mitigates insulin resistance by suppressing adipocyte hypertrophy and increasing serum HMW adiponectin, resulting in upregulation of IRS-1, and IRS-2 expression in muscle. These results further suggest that trehalose is a functional saccharide that may be used to prevent the progression of insulin resistance.

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“…It has been reported that H. erinaceum contains many biologically active compounds, which have shown interesting biological activities, such as hypolipidemic, cytotoxic, anti-microbial, and anti-tumor effects (8). Oral administration of dried Yamabushitake mushroom powder can improve mild cognitive impairment in humans, but little is known about the anti-obesity efficacy of H. erinaceum (9).…”

Section: Introductionmentioning

confidence: 99%

Anti-obesity effect of robusta fermented with Leuconostoc mesenteroides in high-fat diet-induced obese mice

Choi

Ryu

Park

et al. 2017

Experimental and Therapeutic Medicine

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Abstract. Robusta beans cultivated with Monascus ruber (RMR) were successively fermented with Leuconostoc mesenteroides (LM) and the antiobesity effects were examined. To produce an obese mouse model to investigate the hypolipidemic effects, ICR mice were fed the same high-fat diet for 6 weeks. Treatment groups were given 10 or 20% RMR-LM. Body weight changes in the 20% RMR-LM group were lower compared with those in the control group. Visceral adipose tissue weight and adipose size were significantly lower in the 20% RMR-LM group compared with those in the control group. Significant improvement in glucose tolerance was observed in the 10 and 20% RMR-LM groups compared with the control group. The 20% RMR-LM group exhibited a significant reduction in serum glucose concentration. Hepatic mRNA levels of sterol regulatory element-binding protein 1, fas cell surface death receptor, and peroxisome proliferator-activated receptor γ, which are associated with lipid, and fatty acid metabolism, in the 20% RMR-LM group were significantly lower compared with those in the control group. The results of the present study demonstrated that 20% RMR-LM may be used to prevent obesity, and ameliorate diabetes and lipid metabolism imbalances.

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Yamabushitake Mushroom (Hericium erinaceus) Improved Lipid Metabolism in Mice Fed a High-Fat Diet

Cited by 45 publications

References 16 publications

Impact of fasting time on hepatic lipid metabolism in nutritional animal studies

Impact of fasting time on hepatic lipid metabolism in nutritional animal studies

Trehalose Prevents Adipocyte Hypertrophy and Mitigates Insulin Resistance in Mice with Established Obesity

Anti-obesity effect of robusta fermented with Leuconostoc mesenteroides in high-fat diet-induced obese mice

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