Yam-derived exosome-like nanovesicles stimulate osteoblast formation and prevent osteoporosis in mice

Hwang, Jin-Hyeon; Park, Yu-Seong; Kim, Hyuk-Soon; Kim, Dong-Ha; Lee, Sanghoon; Lee, Chan-Hyeong; Lee, Seung‐Hoon; Kim, Jung-Eun; Lee, Sangkyu; Kim, Ho Min; Kim, Hyun Woo; Kim, Jihoon; Seo, Wonhyo; Kwon, Hyojung; Song, Byoung–Joon; Kim, Do-Kyun; Baek, Moon‐Chang; Cho, Young-Eun

doi:10.1016/j.jconrel.2023.01.071

Cited by 34 publications

(23 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, it can be shown that our material enhances the cellular production of mineralized matrix. Since osteoblasts in osteoporosis patients suffer from a reduced ability to form and mineralize bone matrix, 50 the function exhibited by our material has the potential to reverse this pathological state.…”

Section: Resultsmentioning

confidence: 99%

Effect of the Sr–Fe layered double hydroxide coating based on the microenvironment response on implant osseointegration in osteoporotic rats

Liao,

He,

Yin

et al. 2024

J. Mater. Chem. B

View full text Add to dashboard Cite

show abstract

Section: Resultsmentioning

confidence: 99%

Effect of the Sr–Fe layered double hydroxide coating based on the microenvironment response on implant osseointegration in osteoporotic rats

Liao,

He,

Yin

et al. 2024

J. Mater. Chem. B

View full text Add to dashboard Cite

show abstract

“…Researchers have long searched for viable medicines to reverse this tendency and stimulate bone repair (Chen et al 2024). In mice with osteoblasts for bone regeneration in ovariectomized (OVX), researchers discovered that Dioscorea japonica (yam)-derived nanovesicles (YNVs) promoted osteoblast development, mineralization, and bone rebuilding (Hwang et al 2023). Dioscorea yam is a perennial vine that produces a tuber known as yam.…”

Section: Postpone Bone Deteriorationmentioning

confidence: 99%

Plant‐derived nanovesicles offer a promising avenue for anti‐aging interventions

Meng,

Sun,

et al. 2024

Physiologia Plantarum

View full text Add to dashboard Cite

Over the past few years, the study of plant‐derived nanovesicles (PDNVs) has emerged as a hot topic of discussion and research in the scientific community. This remarkable interest stems from their potential role in facilitating intercellular communication and their unique ability to deliver biologically active components, including proteins, lipids, and miRNAs, to recipient cells. This fascinating ability to act as a molecular courier has opened up an entirely new dimension in our understanding of plant biology. The field of research focusing on the potential applications of PDNVs is still in its nascent stages. However, it has already started gaining traction due to the growing interest in its possible use in various branches of biotechnology and medicine. Their unique properties and versatile applications offer promising future research and development prospects in these fields. Despite the significant progress in our understanding, many unanswered questions and mysteries surround the mechanisms by which PDNVs function and their potential applications. There is a dire need for further extensive research to elucidate these mechanisms and explore the full potential of these fascinating vesicles. As the technology at our disposal advances and our understanding of PDNVs deepens, it is beyond doubt that PDNVs will continue to be a subject of intense research in anti‐aging therapeutics. This comprehensive review is designed to delve into the fascinating and multifaceted world of PDNV‐based research, particularly focusing on how these nanovesicles can be applied to anti‐aging therapeutics.

show abstract

“…PEVs are beneficial to periodontal hard tissue repair and regeneration. A recent study demonstrated that yam-derived PEVs (Yam-EVs) improved osteoblast mineralization for bone regeneration in ovariectomized (OVX)-induced osteoporotic mice by activating the BMP-2/p-p38-dependent Runx2 pathway [ 191 ]. As mentioned above, Sundaram et al confirmed that Gr-EVs influenced a series of functions of P. gingivalis and reduced the periodontal inflammation through phosphatidic acid.…”

Section: Pevs and Periodontal Regenerationmentioning

confidence: 99%

The Applications and Potentials of Extracellular Vesicles from Different Cell Sources in Periodontal Regeneration

Huang

Wang

et al. 2023

IJMS

View full text Add to dashboard Cite

Periodontitis is a chronic infectious disease worldwide that can cause damage to periodontal supporting tissues including gingiva, bone, cementum and periodontal ligament (PDL). The principle for the treatment of periodontitis is to control the inflammatory process. Achieving structural and functional regeneration of periodontal tissues is also essential and remains a major challenge. Though many technologies, products, and ingredients were applied in periodontal regeneration, most of the strategies have limited outcomes. Extracellular vesicles (EVs) are membranous particles with a lipid structure secreted by cells, containing a large number of biomolecules for the communication between cells. Numerous studies have demonstrated the beneficial effects of stem cell-derived EVs (SCEVs) and immune cell-derived EVs (ICEVs) on periodontal regeneration, which may be an alternative strategy for cell-based periodontal regeneration. The production of EVs is highly conserved among humans, bacteria and plants. In addition to eukaryocyte-derived EVs (CEVs), a growing body of literature suggests that bacterial/plant-derived EVs (BEVs/PEVs) also play an important role in periodontal homeostasis and regeneration. The purpose of this review is to introduce and summarize the potential therapeutic values of BEVs, CEVs and PEVs in periodontal regeneration, and discuss the current challenges and prospects for EV-based periodontal regeneration.

show abstract

Yam-derived exosome-like nanovesicles stimulate osteoblast formation and prevent osteoporosis in mice

Cited by 34 publications

References 58 publications

Effect of the Sr–Fe layered double hydroxide coating based on the microenvironment response on implant osseointegration in osteoporotic rats

Effect of the Sr–Fe layered double hydroxide coating based on the microenvironment response on implant osseointegration in osteoporotic rats

Plant‐derived nanovesicles offer a promising avenue for anti‐aging interventions

The Applications and Potentials of Extracellular Vesicles from Different Cell Sources in Periodontal Regeneration

Contact Info

Product

Resources

About