Effect of the Sr–Fe layered double hydroxide coating based on the microenvironment response on implant osseointegration in osteoporotic rats

Liao, Chenyu; He, Dongcai; Yin, Kaiwen; Lin, Yuhung; Chen, Yihan; Zhang, Ziqiang; Zhang, Jing; Luo, Hongrong; Chen, Xianchun; Li, Yunfeng

doi:10.1039/d3tb02410e

J. Mater. Chem. B

2024

DOI: 10.1039/d3tb02410e

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Effect of the Sr–Fe layered double hydroxide coating based on the microenvironment response on implant osseointegration in osteoporotic rats

Chenyu Liao,

Dongcai He,

Kaiwen Yin

et al.

Abstract: Osteoporosis is a disease that manifests itself as an abnormality of bone metabolism and is characterized by low bone mass and destruction of the bone microstructure. Since bone resorption occurs...

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Cited by 3 publications

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Intelligent Supramolecular Modification for Implants: Endogenous Regulation of Bone Defect Repair in Osteoporosis

Zhou,

Jiang,

Dang

et al. 2024

Advanced Materials

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Addressing osteoporosis‐related bone defects, a supramolecular strategy is innovated for modifying carbon fiber reinforced polyether ether ketone (CF/PEEK) composites. By covalently attaching intelligent macromolecules via in situ RAFT polymerization, leveraging the unique pathological microenvironment in patients with iron‐overloaded osteoporosis, intelligent supramolecular modified implant surface possesses multiple endogenous modulation capabilities. After implantation, surface brush‐like macromolecules initially resist macrophage adhesion, thereby reducing the level of immune inflammation. Over time, the molecular chains undergo conformational changes due to Fe (III) mediated supramolecular self‐assembly, transforming into mechanistic signals. These signals are then specifically transmitted to pre‐osteoblast cell through the binding capacity of the KRSR short peptide at the molecular terminus, induced their osteogenic differentiation via the YAP/β‐catenin signaling axis. Furthermore, osteoblasts secrete alkaline phosphatase (ALP), which significantly hydrolyzes phosphate ester bonds in surface macromolecular side groups, resulting in the release of alendronate (ALN). This process further improves the local osteoporotic microenvironment. This intelligent surface modification tailors bone repair to individual conditions, automatically realize multiple endogenous regulation once implanted, and truly realize spontaneous activation of a series of responses conducive to bone repair in vivo. It is evidenced by improved bone regeneration in iron‐overloaded osteoporotic rabbits and supported by in vitro validations.

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Intelligent Supramolecular Modification for Implants: Endogenous Regulation of Bone Defect Repair in Osteoporosis

Zhou,

Jiang,

Dang

et al. 2024

Advanced Materials

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Review: osseointegration of titanium-based and zirconia implants: novel perspective on features, influencing factors and improvements

Ji,

Zhang,

Hou

et al. 2024

J Mater Sci

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A comprehensive review on the role of strontium in biodegradable metals

Li,

2024

J. Mater. Chem. B

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Effect of the Sr–Fe layered double hydroxide coating based on the microenvironment response on implant osseointegration in osteoporotic rats

Abstract: Osteoporosis is a disease that manifests itself as an abnormality of bone metabolism and is characterized by low bone mass and destruction of the bone microstructure. Since bone resorption occurs...

Cited by 3 publications

References 51 publications

Intelligent Supramolecular Modification for Implants: Endogenous Regulation of Bone Defect Repair in Osteoporosis

Intelligent Supramolecular Modification for Implants: Endogenous Regulation of Bone Defect Repair in Osteoporosis

Review: osseointegration of titanium-based and zirconia implants: novel perspective on features, influencing factors and improvements

A comprehensive review on the role of strontium in biodegradable metals

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