Y-shaped biotin-conjugated poly (ethylene glycol)–poly (epsilon-caprolactone) copolymer for the targeted delivery of curcumin

Polyphenols delivery by polymeric materials: challenges in cancer treatment

“…By solvent evaporation, PEG in combination with poly(anhydride esters) (PAE) (Lv et al, 2013) and poly(lactic acid) (PLA) carried out to micelles employed as CUR vehicle in HeLa (Lv et al, 2013) in vitro and in MCF-7 cancer cells with considerable results in xenograft mouse model in synergism with DOX . In different studies including in vitro (Gou et al, 2015) or in vivo cancer models, PEG-PCL micelles prepared by self-assembly or thin layer evaporation were proposed for the treatment of ovarian (Gou et al, 2015) and breast (Zhu et al, 2015) cancer cells, breast (Liu et al, 2013), cervical (Mikhail et al, 2014), colon (Mikhail et al, 2014), and lung (Gong et al, 2013;Wang et al, 2013) xenograft mouse model, showing anti-angiogenesis properties in zebrafish (Gong et al, 2013;Wang et al, 2013). A further modification of PEG-PCL micelles by introduction of fatty acids residues (e.g.…”

Biotinylated N-palmitoyl chitosan for design of drug loaded self-assembled nanocarriers

“…Self-aggregated nanoparticles based on biocompatible and biodegradable polymers represent a promising research area, as remarkable properties of such polymers can significantly improve their biological behaviour as drug delivery systems (Yang et al, 2014;Zhu et al, 2015).…”

“…In this regard, a series of small compounds with targeting functions such as: folic acid (Wang et al, 2011), arginine-glycineaspartic acid (Zhao and Zhai, 2013) and biotin (Yang et al, 2014;Zhu et al, 2015) have been widely used as a tumor targeting approach for anti-cancer drugs. Among all, biotin (vitamin B7 or H) is known to be involved in various cellular functions such as: cell growth or signal transduction (Vadlapudi et al, 2012).…”

“…Furthermore, recent studies revealed that overexpression of biotin receptors on the surface of tumoral cells, especially breast cancer cells (Yang et al, 2009) can modulate the uptaken of biotinylated systems through a receptor-mediated endocytosis mechanism (Heo et al, 2012;Bu et al, 2013). Several studies have been devoted to development of active biotinylated compounds (Fernandez-Megia et al, 2007;Yang et al, 2014;Zhu et al, 2015). Docetaxel (DCX), a semisynthetic derivative of taxoid family is an important chemotherapeutic agent against breast, ovarian or lung cancer and intensively used over the past several decades (Jain et al, 2014).…”

Preparation, Characterization and Preliminary Evaluation of Magnetic Nanoparticles based on Biotinylated N-palmitoyl Chitosan

“…Moreover, grafting of hydrophobic chains into chitosan structure, could lead to compounds with new physicochemical characteristics that can exploited to improve drug delivery efficiency [6]. With the same aim, a series of active compounds with targeting functions have been developed and used to formulate various drug delivery systems, such as: micelles, nanoparticles, nanocapsules or hydrogels [7][8][9].…”