Biotinylated N-palmitoyl chitosan for design of drug loaded self-assembled nanocarriers

Preparation, Characterization and Preliminary Evaluation of Magnetic Nanoparticles based on Biotinylated N-palmitoyl Chitosan

“…Biotinylated N-palmitoyl chitosan (codified BPCs) has been obtained through the reaction of N-palmitoyl chitosan with biotin, according to our previous report [9]. Doxorubicin hydrochloride (DOX), sodium tripolyphosphate (TPP) and solvents were purchased from Sigma-Aldrich and used as received.…”

“…Moreover, grafting of hydrophobic chains into chitosan structure, could lead to compounds with new physicochemical characteristics that can exploited to improve drug delivery efficiency [6]. With the same aim, a series of active compounds with targeting functions have been developed and used to formulate various drug delivery systems, such as: micelles, nanoparticles, nanocapsules or hydrogels [7][8][9].…”

“…The interaction between biotin and its avidin type receptors is the strongest known non-covalent biological interaction, very stable and unaffected by a wide range of pH values, temperatures, or other denaturing agents. In addition, recent studies have revealed that biotin-functionalized polymeric nanoparticles encapsulating a chemotherapeutic agent exhibits tumour targeting potential and efficiency drug release into cells subsequent to receptor-mediated endocitosys [9][10][11]. Doxorubicin (DOX) is an antineoplastic agent of the anthracycline family frequently used in association with other drugs to treat a large number of cancers, and particularly breast cancers [12].…”

Development of novel biotinylated chitosan-decorated docetaxel-loaded nanocochleates for breast cancer targeting

“…The BI-CHI conjugate was synthesized according to a method by Balan et al with some modifications [28]. BI (50 mg) solution (2 ml DMSO) was treated with DCC (67.3 gm) and NHS (31.3 gm) for 30 min at 4 C in order to activate BI.…”

“…Some of the works involving chitosan in nanoparticles [25][26][27] signify the efficiency of the polymer being used in nanomedicine and the future it beholds over scientific advancement. CHI can be covalently conjugated with the acid group of BI [28] and the conjugated BI-CHI has two amino groups under resonance in BI end and hydroxyl groups in CHI end thereby localizing charges on the terminal end which facilitate strong electrostatic interaction between biomolecules and NCs which acts as novel drug formulation.…”