Xyy Chromosomal Constitution With Genital Abnormality

Males with an XYY sex chromosome complement.

“…The cases described by Vignetti et al (1964), Forsberg et al (1965), and Franks et al (1967 have certain features in common, and all three differ from the case discussed above and reported by de Grouchy et al (1963). Vignetti et al reported on a 3-year-old female ofnormal growth and intelligence, who had a somewhat enlarged clitoris, a normally developed urethra but no vaginal orifice, and a mass in each labium majus eventually shown to be a testis.…”

“…There are, however, a number of reports of females with a 47,XYY complement (de Grouchy et al, 1963;Vignetti, Capotorti, and Ferrante, 1964;Forsberg, Hall, and Ryden, 1965;Franks, Bunting, and Engel, 1967), three of which are dflicult to explain on the argument that they are unrecognized mosaics of the 45,X/47,XYY type. The case of de Grouchy et al may be relatively straightforward.…”

The causes of congenital club foot.

“…A. McBridge, 1962, personal communication;Castilla and Breg, 1963;Court Brown, Harnden, Jacobs, Maclean, and Mantle, 1964;Fraccaro, Davies, Glen Bott, and Schutt, 1962;Hustinx and Val Olphen, 1963;St. M. Milcu, I. Negoescu, M. Garoiu, I. Iliescu, M. Augustin, and C. Maximilian, 1963, personal communication;Ricci and Malacarne, 1964;Sandberg, Ishihara, Crosswhite, and Koepf, 1963;Vignetti, Capotorti, and Ferrante, 1964). In a further unpublished case (Paediatric Research Unit, H2599/359) bilateral calcaneovarus and flexion deformities of the knees were found.…”

“…M. Milcu, I. Negoescu, M. Garoiu, I. Iliescu, M. Augustin, and C. Maximilian, 1963, personal communication;Ricci and Malacarne, 1964;Sandberg, Ishihara, Crosswhite, and Koepf, 1963;Vignetti, Capotorti, and Ferrante, 1964). In a further unpublished case (Paediatric Research Unit, H2599/359) bilateral calcaneovarus and flexion deformities of the knees were found.…”

Two New Cases of XYY Chromosome Complement: And a Review of the Literature

“…There are also a few isolated case histories of XYY chromosome complement associated with epilepsy (14), multiple congenital abnormalities (20), abnormal electrocardiograms (31) and genital abnormality (40).…”