Xylomexicanins C and D, New Mexicanolide-Type Limonoids from <i>Xylocarpus granatum</i>

Wu, Yi Bing; Ni, Zhi Yu; Huo, Chang Hong; Su, Jian; Dong, Ming; Sauriol, Françoise; Shi, Xiaowei; Gu, Yu‐Cheng; Kiyota, Hiromasa

doi:10.1271/bbb.120815

Cited by 17 publications

(4 citation statements)

References 13 publications

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“…969 Two triterpenes tiliacol A 1185 and B 1186 were isolated from the semi-mangrove plant Hibiscus tiliaceus (Hainan Is., China). 970 A diverse range of liminoids were reported from extracts of Xylocarpus granatum: granatumins H-K 1187-1190 (seeds, Krishna estuary, Andhra Pradesh), 971 xylomexicanins C 1191 and D 1192 (seeds, Hainan Province, China), 972 and xylogranins A 1193 and B 1194 (leaves, Sundarbans Mangrove Forest, Bangladesh). 973 Xylomexicanin C 1191 exhibited modest cytotoxicity towards a breast tumour cell line, while xylogranin B 1194 and co-metabolite swietephragmin were potent inhibitors of the Wnt signalling pathway and exhibited sub-micromolar cytotoxicity towards two human colorectal tumour cell lines.…”

Section: Echinodermsmentioning

confidence: 99%

Marine natural products

et al. 2015

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This review covers the literature published in 2013 for marine natural products (MNPs), with 982 citations (644 for the period January to December 2013) referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms. The emphasis is on new compounds (1163 for 2013), together with the relevant biological activities, source organisms and country of origin. Reviews, biosynthetic studies, first syntheses, and syntheses that lead to the revision of structures or stereochemistries, have been included.

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Section: Echinodermsmentioning

confidence: 99%

Marine natural products

et al. 2015

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“…8). Nearly 300 mexicanolides ( C1–C294 ) 36,51,56,64,70–73,84–86,98,126,129,144,162,183,189,190,199,201,206,207,209,210,215–266 were isolated from 21 plant species belonging to 14 genera (Table S1.11†), of which the genera Xylocarpus (147, 48.0%), Khaya (36, 12.2%), and Trichilia (33, 11.2%) contributed the most. 9,10- Seco mexicanolides ( C271–C294 ) were rare in previous studies and were mainly isolated from Xylocarpus , which included four 30(8→9)- abeo -mexicanolides ( C290–C293 ).…”

Section: Latest Limonoids Discovered From the Meliaceae Familymentioning

confidence: 99%

Research progress of meliaceous limonoids from 2011 to 2021

Luo

Sun

et al. 2022

Nat. Prod. Rep.

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“…xylomexicanins A-D, I, and J [32][33][34]; xyloccensins I, K, L, O-S, V, W, and Y [10,12,35,36]; hainangranatumins A-J [37]; xylogranatins F-R [38]; thaigranatins A-E [39];…”

Section: Phytochemistrymentioning

confidence: 99%

Ethnomedicinal Use, Phytochemistry, and Pharmacology of Xylocarpus granatum J. Koenig

Dey

Quispe

Hossain

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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The mangrove plants are the potential sources of foods and remedies for people living in the forests and nearby communities. Xylocarpus granatum J. Koenig is traditionally used to treat various diseases including diarrhea, cholera, dysentery, fever, malaria, and viral infections, among others. To summarize critically the taxonomy, ethnomedicinal, phytochemistry, and pharmacological activities of X. granatum, information was collected from different databases. An up-to-date search (till June 2020) was carried out with the help of various scientific web resources from databases such as PubMed, Science Direct, Google Scholar, and various patent offices (e.g., WIPO, CIPO, and USPTO) using the keywords “Xylocarpus granatum” and then paired with ethnomedicinal use and phytochemical, phytochemistry, and pharmacological activity (in vitro, ex vivo, and in vivo studies). Findings revealed that seeds, fruits, stem bark, leaf, and twigs of X. granatum exhibited a wide range of key phytochemicals including limonoids, phragmalin, limonoid-based alkaloids, mexicanolides, protolimonoids, flavonols, and lactones. The plant possessed potent antioxidant, anticancer, antidiabetic, antimicrobial, antimalarial, antifeedant, and neuroprotective activities. No clinical studies have been reported in the databases. Ethnomedicinal assessment indicated the application of X. granatum in various fields of medical science specially to treat various human ailments, and this was attributed to the presence of enormous alkaloids as confirmed by pharmacological studies. However, to understand the mechanism of action in-depth studies are required. In view of these findings, more research is necessary to explore and characterize the chemical compounds and toxicological aspects of this medicinal mangrove plant. Overall, it can be stated that X. granatum may be one of the hopeful medicinal herbs for the treatment of various diseases in human beings.

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Xylomexicanins C and D, New Mexicanolide-Type Limonoids from Xylocarpus granatum

Cited by 17 publications

References 13 publications

Marine natural products

Marine natural products

Research progress of meliaceous limonoids from 2011 to 2021

Ethnomedicinal Use, Phytochemistry, and Pharmacology of Xylocarpus granatum J. Koenig

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