Xyloglucan nano-aggregates: Physico-chemical characterisation in buffer solution and potential application as a carrier for camptothecin, an anti-cancer drug

Jó, Tatiane A.; Petri, Denise Freitas Siqueira; Beltramini, Leila Maria; Lucyszyn, Neoli; Sierakowski, Maria Rita

doi:10.1016/j.carbpol.2010.04.072

Cited by 39 publications

(8 citation statements)

References 70 publications

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“…They have a 4-linked ␤-d-glucan backbone, substituted at position O-6 by branches of ␣-d-xylose or of ␤-d-galactose-1→2-␣-d-xylose disaccharide [3][4][5]. Xyloglucans can be extracted from seeds of different species such as Copaifera…”

Section: Introductionmentioning

confidence: 99%

Structure and rheological properties of a xyloglucan extracted from Hymenaea courbaril var. courbaril seeds

Arruda

Albuquerque

Santos

et al. 2015

International Journal of Biological Macromolecules

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Hymenaea courbaril var courbaril seed xyloglucan was efficiently extracted with 0.1M NaCl, followed by ethanol precipitation (yield=72±5% w/w). Its amorphous structure was identified by the pattern of X-ray diffraction. The monosaccharide composition was determined by GC/MS analysis of the alditol acetates and showed the occurrence of glucose:xylose:galactose:arabinose (40:34:20:6). One-(1D) and two-dimensional-(2D) NMR spectra confirmed a central backbone composed by 4-linked β-glucose units partially branched at position 6 with non-reducing terminal units of α-xylose or β-galactose-(1→2)-α-xylose disaccharides. The xyloglucan solution was evaluated by dynamic light scattering and presents a polydisperse and practically neutral profile, and at 0.5 and 1.0% (w/v) the solutions behave as a viscoelastic fluid. The polysaccharide did not show significant antibacterial or hemolytic activities. Overall our results indicate that xyloglucan from H. courbaril is a promising polysaccharide for food and pharmaceutical industries.

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Section: Introductionmentioning

confidence: 99%

Structure and rheological properties of a xyloglucan extracted from Hymenaea courbaril var. courbaril seeds

Arruda

Albuquerque

Santos

et al. 2015

International Journal of Biological Macromolecules

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“…Tamarind gum comprises of xyloglucan, which is a type of storage or structural heteropolysaccharide. In xyloglucan, 1,4‐linked ß‐D‐glucan main chain is partially substituted with α‐D‐xylose side chains at the O6 atoms (Jó, Petri, Beltramini, Lucyszyn, & Sierakowski, ). The branches of the xyloglucan result in the variation of the viscosity and the stability apart from conformational flexibility of the main chain.…”

Section: Resultsmentioning

confidence: 99%

“…Although the xyloglucans are water‐soluble, the individual macromolecules do not fully hydrate. This causes the formation of aggregated species even in very dilute solutions (Jó et al, ). The analysis of the micrographs suggests the formation of a hydrogel‐in‐oleogel type of bigel.…”

Section: Resultsmentioning

confidence: 99%

Development of Bigels Based on Stearic Acid–Rice Bran Oil Oleogels and Tamarind Gum Hydrogels for Controlled Delivery Applications

Paul

Qureshi

Yogalakshmi

et al. 2018

J Surfact & Detergents

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In the last few decades, different types of gels have been widely studied as potential drug delivery carriers. In this paper, we propose the synthesis of an oleogel, a tamarind gum hydrogel, and bigels for applications as drug delivery matrices. The oleogel was prepared by mixing stearic acid and rice bran oil, whereas the hydrogel was prepared by mixing tamarind gum with a hydroethanolic solution. Hydrogel-in-oleogel and oleogel-in-hydrogel bigels were prepared by mixing the hydrogel and the oleogel. The suitability of the formulations for controlled drug release applications was thoroughly examined using microscopy, Fourier transform infrared (FTIR) spectroscopy, as well as mechanical, electrical, thermal, drug release, and antimicrobial studies. An alteration in the microarchitecture of the bigels is observed when the oleogel and the hydrogel are mixed in varying proportions. The associative interactions within the formulations increase with the increase in the hydrogel content. The bigels exhibit the presence of stearic acid melting endotherm (associated with the oleogel) and water evaporation endotherm (associated with the hydrogel). This study suggests that the hydrogel has lowest bulk resistance compared to the other formulations. The structural breakdown of the bigels is composition-dependent, and the bulk electrical resistance is mainly governed by the oleogel phase. An increase in the diffusion of the moxifloxacin HCl from the formulations is observed with the increase of the hydrogel proportion, which in turn increases the rate of release of the drug. The proposed formulations also exhibit good antimicrobial efficacy. The analysis of these properties suggests that specific formulations can be tailored by need-based applications of the drug release rate.Keywords Oleogel Á Hydrogel Á Hydrogel-in-oleogel bigel Á Oleogel-in-hydrogel bigel Á Moxifloxacin HCl Á Antimicrobial activity J Surfact Deterg (2018) 21: 17-29.

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“…In the typical structure, the backbone is composed of 1,4-linked ␤-Glcp, which is substituted at O-6 by Xylp. Studies also indicate that xyloglucan binds with cellulose tightly, and can make the cellulose layer loose, which is necessary for the growth of cells in general [9][10][11]. In this paper, a polysaccharide with anti-angiogenic activity was obtained, and its structural characterization was elucidated by chemical methods and spectroscopic analyses.…”

Section: Introductionmentioning

confidence: 98%

Structural elucidation of a polysaccharide from Chrysanthemum morifolium flowers with anti-angiogenic activity

Zheng

Dong

et al. 2015

International Journal of Biological Macromolecules

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Xyloglucan nano-aggregates: Physico-chemical characterisation in buffer solution and potential application as a carrier for camptothecin, an anti-cancer drug

Cited by 39 publications

References 70 publications

Structure and rheological properties of a xyloglucan extracted from Hymenaea courbaril var. courbaril seeds

Structure and rheological properties of a xyloglucan extracted from Hymenaea courbaril var. courbaril seeds

Development of Bigels Based on Stearic Acid–Rice Bran Oil Oleogels and Tamarind Gum Hydrogels for Controlled Delivery Applications

Structural elucidation of a polysaccharide from Chrysanthemum morifolium flowers with anti-angiogenic activity

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