Xylitol nasal irrigation in the treatment of chronic rhinosinusitis

Lin, Lin; Tang, Xinyue; Wei, Jinjin; Dai, Fei; Sun, Guangbin

doi:10.1016/j.amjoto.2017.03.006

Cited by 26 publications

(34 citation statements)

References 24 publications

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“…It is already being used in otorhinolaryngology as a nasal spray and lavage for the treatment of rhinosinusitis and the prevention of otitis media. [22,23]. Studies "in vitro" and in animal models has shown antiviral properties of Xylitol against human respiratory syncytial virus (24).…”

Section: Introductionmentioning

confidence: 99%

Iota-carrageenan and Xylitol inhibit SARS-CoV-2 in cell culture

Bansal

Jonsson

Taylor³

et al. 2020

Preprint

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COVID-19 (coronavirus disease 2019) is a pandemic caused by SARS-CoV-2 (severe acute respiratory syndrome-coronavirus 2) infection affecting millions of persons around the world. There is an urgent unmet need to provide an easy-to-produce, affordable medicine to prevent transmission and provide early treatment for this disease. The nasal cavity and the rhinopharynx are the sites of initial replication of SARS-CoV-2. Therefore, a nasal spray may be a suitable dosage form for this purpose. The main objective of our study was to test the antiviral action of three candidate nasal spray formulations against SARS-CoV-2. We have found that iota-carrageenan in concentrations as low as 6 mcg/ mL inhibits SARS-CoV-2 infection in Vero cell cultures. The concentrations found to be active in vitro against SARS-CoV-2 may be easily achieved by the application of nasal sprays already marketed in several countries. Xylitol at a concentration of 5 % m/V has proved to be viricidal on its own and the association with iota-carrageenan may be beneficial, as well.

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Section: Introductionmentioning

confidence: 99%

Iota-carrageenan and Xylitol inhibit SARS-CoV-2 in cell culture

Bansal

Jonsson

Taylor³

et al. 2020

Preprint

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“…51 Some promising CAM therapies for CRS that have been excluded in this study are xylitol, manuka honey, and dead sea salt (DSS). In previous RCTs, 52,53 sinonasal irrigation with 5% xylitol led to greater improvement in SNOT-20/22 compared to saline control. Manuka honey spray also led to an improved QoL score in a subset of adults with allergic fungal rhinosinusitis.…”

Section: Discussionmentioning

confidence: 82%

Complementary and Alternative Medicine in Chronic Rhinosinusitis: A Systematic Review and Qualitative Analysis

Jin

Chin

2018

Am J Rhinol�Allergy

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Background Complementary and alternative medicine (CAM) is frequently used in the treatment of chronic rhinosinusitis (CRS) in developed countries. With a plethora of CAM therapies available, their effectiveness and safety are poorly understood in the context of CRS. Objectives This article aims to critically appraise the evidence for CAM use in CRS through a systematic review of current literature that investigate the effects of CAM on symptoms and clinical status of adults with CRS. Study Design Systematic review and qualitative analysis. Review Methods A comprehensive systematic review of the literature was conducted by the authors using 5 databases from inception to July 2017: CINAHL, Cochrane, Embase, PubMed, and SCOPUS. Inclusive medical subject headings and keywords consisted of, but were not limited to, sinusitis and complementary therapies, naturopathy, or traditional Chinese medicine. PRISMA guideline was followed. Using templates by Cochrane Public Health Group and Newcastle-Ottawa Scale, each author extracted data, assessed bias, and computed minimal clinically important difference. Any conflicts were resolved through discussion. Results In total, 7 of 7141 articles from 1995 to 2016 were included. Three randomized controlled trials and 4 observational studies were organized into 4 categories of CAM: naturopathy, Chinese medicine, homeopathy, and others. Limited evidence supported the use of Pimpinella anisum and crenotherapy for CRS. Data available on Chinese medicine, homeopathy, and liposomal therapy in CRS were inconclusive due to inherent flaws in the studies. Conclusion Overall, there is very limited evidence to support the use of CAM in the treatment of CRS. No significant adverse effects have been found. Given its widespread use, more rigorous data from high-quality research are needed before it can be routinely recommended.

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“…However, previous administration of xylitol in an infected sinus did not decrease bacterial counts. Weissman et al and Lin et al performed human studies evaluating the effect of xylitol in patients with CRS. Although only 75% of the patients completed both studies, those in the xylitol group showed significant improvement SNOT‐22 scores compared with the saline group (Table ).…”

Section: Resultsmentioning

confidence: 99%

Future topical medications in chronic rhinosinusitis

Miyake

Bleier

2019

Int Forum Allergy Rhinol

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Background:Research has progressed rapidly in recent decades to be er understand the etiopathogenesis and management paradigms of chronic rhinosinusitis (CRS). Although oral antibiotics o en mitigate symptoms in acute CRS exacerbations, eradication of polymicrobial biofilms and multidrug-resistant bacteria remains a challenge. The goal of this review is to summarize and discuss the potential and pitfalls of topical medications in the treatment of CRS. Methods:A related literature review was performed using PubMed and Scopus, with only the English database included. Results:The main therapies were selected and separated in sections. Details regarding future topical treatments of CRS were summarized and discussed. Conclusion:The ease of access of the sinonasal mucosa positions CRS as a disease with high potential for local topical treatment. The ultimate adoption of topical agents will require continued expansion of our understanding of novel local targets in CRS as well as improved methods to deliver and retain the drug of interest at the site of activity. C 2019 ARS-AAOA, LLC.

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Xylitol nasal irrigation in the treatment of chronic rhinosinusitis

Cited by 26 publications

References 24 publications

Iota-carrageenan and Xylitol inhibit SARS-CoV-2 in cell culture

Iota-carrageenan and Xylitol inhibit SARS-CoV-2 in cell culture

Complementary and Alternative Medicine in Chronic Rhinosinusitis: A Systematic Review and Qualitative Analysis

Future topical medications in chronic rhinosinusitis

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