Complementary and Alternative Medicine in Chronic Rhinosinusitis: A Systematic Review and Qualitative Analysis

Jin, Andy; Chin, Christopher J.

doi:10.1177/1945892418813079

Cited by 5 publications

(1 citation statement)

References 49 publications

(72 reference statements)

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“…23 Some alternative therapies show promise as potential treatments for CRS, compared with placebo or as adjuncts to usual care, but based on the limited quality data there is scarce evidence to support the use of homeopathy in CRS. 24 Homeopathy research on sinusitis comprises both acute and chronic conditions. No systematic reviews or metaanalysis could be identified on the subject.…”

Section: Introductionmentioning

confidence: 99%

Individualized Homeopathic Medicines in Chronic Rhinosinusitis: Randomized, Double-Blind, Placebo-Controlled Trial

et al. 2020

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Background Chronic rhinosinusitis (CRS) is a common disorder, with up to an estimated 134 million Indian sufferers, and having significant impact on quality of life (QOL) and health costs. Despite the evidence favoring homeopathy in CRS being inadequate, it is highly popular. This trial attempts to study the efficacy of individualized homeopathy (IH) medicines in comparison with placebo in patients with CRS. Methods A double-blind, randomized (1:1), placebo-controlled, preliminary trial (n = 62) was conducted at the National Institute of Homoeopathy, West Bengal, India. Primary outcome measure was the sino-nasal outcome test-20 (SNOT-20) questionnaire; secondary outcomes were the EQ-5D-5L questionnaire and EQ-5D-5L visual analog scale scores, and five numeric rating scales (0–10) assessing intensity of sneezing, rhinorrhea, post-nasal drip, facial pain/pressure, and disturbance in sense of smell, all measured at baseline and after the 2nd and 4th months of intervention. Group differences and effect sizes (Cohen's d) were calculated on the intention-to-treat sample. Results Groups were comparable at baseline. Attrition rate was 6.5% (IH: 1, Placebo: 3). Although improvements in both primary and secondary outcome measures were higher in the IH group than placebo, with small to medium effect sizes, the group differences were statistically non-significant (all p > 0.05, unpaired t-tests). Calcarea carbonica, Lycopodium clavatum, Sulphur, Natrum muriaticum and Pulsatilla nigricans were the most frequently prescribed medicines. No harmful or unintended effects, homeopathic aggravations or any serious adverse events were reported from either group. Conclusion There was a small but non-significant direction of effect favoring homeopathy, which ultimately renders the trial as inconclusive. Rigorous trials and independent replications are recommended to arrive at a confirmatory conclusion. [Trial registration: CTRI/2018/03/012557; UTN: U1111–1210–7201].

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Section: Introductionmentioning

confidence: 99%

Individualized Homeopathic Medicines in Chronic Rhinosinusitis: Randomized, Double-Blind, Placebo-Controlled Trial

et al. 2020

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Medical management of rhinitis in pregnancy

Gupta

Anari

2022

Auris Nasus Larynx

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Efficacy of Homoeopathy in Managing Respiratory Infections beyond Doubt!—A Narrative Review

2020

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Background Coronavirus disease 2019 (COVID-19) or severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is accountable for significant mortality worldwide. This virus is primarily infecting the respiratory tract and resulting in SARS. There is no precise treatment available till today. Thus, it is important to find out the alternative approach which can reduce the burden of disease. Objective The aim of this review is to summarise and appraise the findings of various studies on respiratory infections in homoeopathy. Methods A comprehensive search of the articles published during the period from 1 January 2000 to 15 June 2020 on homoeopathy and respiratory infections was carried out. Major electronic medical databases such as PubMed, Cochrane Database of Systematic Reviews, CORE-Hom and CAM-QUEST were used for the literature search. Result From the literature search 46 studies congregated out of which 9 were systematic reviews, 18 randomised contolled trials, 1 controlled clinical trial, 13 comparative cohorts, 3 single-arm cohort observational studies, 1 case series and 1 case report. The results of this review are encouraging. Homeopathic medications have a positive effect in reducing the number of attacks of respiratory infections, less antibiotic usage, tolerability and good compliance as compared to conventional treatment. Complex homeopathic medicine showed a promising role in combating respiratory infections. Homeopathy has shown an important role as adjuvant therapy. Conclusion The findings of this review seem to suggest a definite role of homeopathy beyond placebo in the treatment of various conditions of respiratory infections. Applying homeopathy as an adjunctive treatment in COVID-19 cases can be cost-effective, feasible and safe. Owing to the heterogeneity in trials, independent replications and further appraisal with rigorous designs are warranted.

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Complementary and Alternative Medicine in Chronic Rhinosinusitis: A Systematic Review and Qualitative Analysis

Cited by 5 publications

References 49 publications

Individualized Homeopathic Medicines in Chronic Rhinosinusitis: Randomized, Double-Blind, Placebo-Controlled Trial

Individualized Homeopathic Medicines in Chronic Rhinosinusitis: Randomized, Double-Blind, Placebo-Controlled Trial

Medical management of rhinitis in pregnancy

Efficacy of Homoeopathy in Managing Respiratory Infections beyond Doubt!—A Narrative Review

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