Xylans of Industrial and Biomedical Importance

Ebringerová, Anna; Hromàdková, Zdenka

doi:10.1080/02648725.1999.10647982

Cited by 93 publications

(64 citation statements)

References 136 publications

(27 reference statements)

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“…Aldouronates, acidic xylooligosaccharides (U-XOS) containing one or more methylglucuronate residues linked ␣-1,2 to xylose residues in the ␤-1,4-xylan backbone in methylglucuronoxylans, have been shown to have a range of immunomodulating and antimicrobial activities (4,5,40,41). These have received increasing attention for additional applications, including the production of pentosan polysulfate (PPS).…”

Section: Discussionmentioning

confidence: 99%

“…Neutral forms of these ␤-1,4-linked xylooligosaccharides have been reported to serve as prebiotics (1)(2)(3) and anti-inflammatory agents (4). Aldouronates, acidic xylooligosaccharides (U-XOS and U-AXOS, where U represents uronate) in which some xylose (X) residues are substituted with ␣-1,2-linked 4-O-methylglucuronate (MeG), have been shown to exhibit anti-inflammatory and other immunomodulating activities (5). These acidic forms comprise a portion of the pentosans that are used for the preparation of pentosan polysulfates (PPSs), which have several medical applications, including the treatment of interstitial cystitis, mucopolysaccharidoses, and osteoarthritis (6)(7)(8).…”

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confidence: 99%

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Engineering the Xylan Utilization System in Bacillus subtilis for Production of Acidic Xylooligosaccharides

Rhee

Sawhney

et al. 2014

Appl Environ Microbiol

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cXylans are the predominant polysaccharides in hemicelluloses and an important potential source of biofuels and chemicals. The ability of Bacillus subtilis subsp. subtilis strain 168 to utilize xylans has been ascribed to secreted glycoside hydrolase family 11 (GH11) and GH30 endoxylanases, encoded by the xynA and xynC genes, respectively. Both of these enzymes have been defined with respect to structure and function. In this study, the effects of deletion of the xynA and xynC genes, individually and in combination, were evaluated for xylan utilization and formation of acidic xylooligosaccharides. Parent strain 168 depolymerizes methylglucuronoxylans (MeGX n ), releasing the xylobiose and xylotriose utilized for growth and accumulating the aldouronate methylglucuronoxylotriose (MeGX 3 ) with some methylglucuronoxylotetraose (MeGX 4 ). The combined GH11 and GH30 activities process the products generated by their respective actions on MeGX n to release a maximal amount of neutral xylooligosaccharides for assimilation and growth, at the same time forming MeGX 3 in which the internal xylose is substituted with methylglucuronate (MeG). Deletion of xynA results in the accumulation of ␤-1,4-xylooligosaccharides with degrees of polymerization ranging from 4 to 18 and an average degree of substitution of 1 in 7.2, each with a single MeG linked ␣-1,2 to the xylose penultimate to the xylose at the reducing terminus. Deletion of the xynC gene results in the accumulation of aldouronates comprised of 4 or more xylose residues in which the MeG may be linked ␣-1,2 to the xylose penultimate to the nonreducing xylose. These B. subtilis lines may be used for the production of acidic xylooligosaccharides with applications in human and veterinary medicine.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Engineering the Xylan Utilization System in Bacillus subtilis for Production of Acidic Xylooligosaccharides

Rhee

Sawhney

et al. 2014

Appl Environ Microbiol

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“…Xylan has been considered as a suitable raw material to produce colonic drug delivery systems as it is biodegraded by enzymes produced by the colonic microflora [53][54][55]. Physiological effects of Xylans: Viscous character of the fiber polysaccharides in cereals leads to the faecal bulking effect and lowering of blood cholesterol and decrease of postprandial glucose and insulin responses.…”

Section: Chitosanmentioning

confidence: 99%

Biomedical Biopolymers, their Origin and Evolution in Biomedical Sciences: A Systematic Review

Yadav

Yadav²,

Shah

et al. 2015

JCDR

111

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“…Hemicelluloses have found numerous applications such as biomaterials (hydrogels, films, membranes, fibers, biocomposites), special chemicals (food additives, cosmetics, drug carriers, plant growth regulators), and pharmaceuticals (wound management aids), etc. (Ebringerova 2012;Ebringerova and Hromadkova 1999;Ebringerova et al 2005;Hansen and Plackett 2008;Li and Pan 2010).…”

Section: Graded Ethanol Fractionation and Structural Characterizationmentioning

confidence: 99%

Graded Ethanol Fractionation and Structural Characterization of Alkali-Extractable Hemicelluloses from Olea europaea L.

Peng¹,

Bian²,

Li³

et al. 2013

BioResources

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Dewaxed Olea europaea L. was subjected to delignification followed by alkali extraction with 10% KOH containing 1% H 3 BO 3 . The released hemicelluloses were fractionated by precipitation through acidification and ethanol solutions with increasing concentrations from 20 to 30, 40, 50, 60, 70, and 90%. The structure of the subfractions obtained was comparatively characterized by sugar analysis, molecular weight, FT-IR, and NMR spectroscopy. Results indicated that 23.5% of hemicelluloses (% of the dewaxed material) were isolated by the alkaline extraction. An increase of ethanol concentration resulted in the precipitation of the more branched hemicelluloses as indicated by the increase of the ratios of arabinose to xylose and uronic acids to xylose. The hemicellulose subfractions Ha (precipitated by acidification to pH 5.5) and H30 (precipitated by 30% ethanol solution) had a similar structure, which was assumed to be glucuroxylan together with a small amount of α-glucan, whereas the hemicellulose subfraction H70 (precipitated by 70% ethanol solution) had a more complicated structure, which was mainly composed of a (1→4)-linked β-D-xylopyranosyl backbone with various side chains. The comprehensive structural characterization of the hemicelluloses of this species provides fundamental information for their potential applications in the fields of materials, chemicals, and energy production.

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Xylans of Industrial and Biomedical Importance

Cited by 93 publications

References 136 publications

Engineering the Xylan Utilization System in Bacillus subtilis for Production of Acidic Xylooligosaccharides

Engineering the Xylan Utilization System in Bacillus subtilis for Production of Acidic Xylooligosaccharides

Biomedical Biopolymers, their Origin and Evolution in Biomedical Sciences: A Systematic Review

Graded Ethanol Fractionation and Structural Characterization of Alkali-Extractable Hemicelluloses from Olea europaea L.

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