Xylan-based temperature/pH sensitive hydrogels for drug controlled release

Gao, Cundian; Ren, Junli; Zhao, Cui; Kong, Weiqing; Dai, Qi-Shan; Chen, Qifeng; Liu, Chuanfu; Sun, Run‐Cang

doi:10.1016/j.carbpol.2016.05.075

Cited by 113 publications

(56 citation statements)

References 44 publications

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“…Among these environmental factors, temperature is important because it is easy to control and plays an important role in crop growth. Temperature-sensitive hydrogels have comprehensive applications in the controlled release of drugs, tissue culture, and the immobilization of protein [22][23][24]. In agriculture, temperature-responsive polymers have been investigated as pesticide carriers, as the release rate can be controlled to meet the requirements of pest prevention [25,26].…”

Section: Introductionmentioning

confidence: 99%

Thermosensitive Hydrogel for Encapsulation and Controlled Release of Biocontrol Agents to Prevent Peanut Aflatoxin Contamination

et al. 2020

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Starch, alginate, and poly(N-isopropylacrylamide) (PNIPAAm) were combined to prepare a semi-interpenetrating network (IPN) hydrogel with temperature sensitivity. Calcium chloride was used as cross-linking agent, the non-toxigenic Aspergillus flavus spores were successfully encapsulated as biocontrol agents by the method of ionic gelation. Characterization of the hydrogel was performed by Fourier-transform infrared spectroscopy (FTIR), scanning electron micrograph (SEM), and thermogravimetry analysis (TGA). Formulation characteristics, such as entrapment efficiency, beads size, swelling behavior, and rheological properties were evaluated. The optical and rheological measurements indicated that the lower critical solution temperature (LCST) of the samples was about 29–30 °C. TGA results demonstrated that the addition of kaolin could improve the thermal stability of the semi-IPN hydrogel. Morphological analysis showed a porous honeycomb structure on the surface of the beads. According to the release properties of the beads, the semi-IPN hydrogel beads containing kaolin not only have the effect of slow release before peanut flowering, but they also can rapidly release biocontrol agents after flowering begins. The early flowering stage of the peanut is the critical moment to apply biocontrol agents. Temperature-sensitive hydrogel beads containing kaolin could be considered as carriers of biocontrol agents for the control of aflatoxin in peanuts.

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Section: Introductionmentioning

confidence: 99%

Thermosensitive Hydrogel for Encapsulation and Controlled Release of Biocontrol Agents to Prevent Peanut Aflatoxin Contamination

et al. 2020

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“…The aim of a controlled drug release system is to transfer the drug molecules to the target at a specific rate to maintain a predetermined concentration of drug in the release medium for a predetermined period of time. Hydrogels with controlled release properties improve therapeutic effectiveness of the drugs and reduce their side effects . The swelling ability of hydrogels allows them to absorb and release high quantities of drugs .…”

Section: Introductionmentioning

confidence: 99%

Synthesis and controlled release of curcumin‐β‐cyclodextrin inclusion complex from nanocomposite poly(N‐isopropylacrylamide/sodium alginate) hydrogels

Kasapoglu‐Calik

Özdemir

2019

J of Applied Polymer Sci

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Inclusion complex of curcumin with β-cyclodextrin (Cur-β-CD) was prepared using coprecipitation method. Stoichiometric ratio between curcumin and β-cyclodextrin was found to be 1:2 with an association constant of 3.80 × 10 8 M −2 using Benesi-Hildebrand method. Inclusion complex formation was confirmed by FTIR and DSC analyses. Water solubility of curcumin increased from 0.00122 to 0.721 mg mL −1 with the inclusion complex formation. Release of the inclusion complex from the nanocomposite and conventional poly(N-isopropylacrylamide/sodium alginate hydrogels crosslinked by nanoclay and N,N 0 -methylenebis(acrylamide) (BIS), respectively, were investigated in simulated gastrointestinal conditions. Swelling ratio and cumulative release were dependent on the hydrogel composition and pH. At pH = 1.2, hydrogels showed the lowest release ratio, but at pH = 6.8 highest swelling ratios were attained. The swelling ratio and cumulative release decreased with increasing the nanoclay content in nanocomposite hydrogels. On the contrary, as the ratio of BIS in the conventional hydrogels increased, the swelling ratio and cumulative release increased.

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“…Therefore, effective controlled sequential release systems need to be developed, which exhibit controlled release, low toxicity, biodegradability, and biocompatibility and as much as possible possess the advantages of high encapsulation efficiency. The introduction of biocompatibility comonomers has become the effective way to obtain biocompatible polymers as the ideal drug carriers of cancer . Saikia et al fabricated thermosensitive polyethylene glycol (PEG)/Poly(N‐isopropylacrylamide‐2‐acrylamido‐2‐methylpropanesulphonic acid) [P(NIPAM‐co‐AMPS] hydrogels, which had good biocompatibility because of the macroinitiator PEG.…”

Section: Introductionmentioning

confidence: 99%

“…The introduction of biocompatibility comonomers has become the effective way to obtain biocompatible polymers as the ideal drug carriers of cancer. [9][10][11] Saikia et al 9 fabricated thermosensitive polyethylene glycol (PEG)/Poly(N-isopropylacrylamide-2-acrylamido-2methylpropanesulphonic acid) [P(NIPAM-co-AMPS] hydrogels, which had good biocompatibility because of the macroinitiator PEG. The obtained thermosensitive PEG/poly(NIPAM-co-AMPS) gels can be used as controlled drug delivery systems.…”

Section: Introductionmentioning

confidence: 99%

Preparation of thermo/redox/pH‐stimulative poly(N‐isopropylacrylamide‐co‐N,N′‐dimethylaminoethyl methacrylate) nanogels and their DOX release behaviors

Gao

Duan

et al. 2019

J Biomedical Materials Res

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Stimuli‐sensitive drug delivery systems show beneficial features of both medical and pharmaceutical fields. In this article, polymeric nanogel P (N‐isopropylacrylamide–N,N ′‐dimethylaminoethyl methacrylate [NIPAM–DMAEMA]) (PND) with pH/redox/thermo‐responsivenesses was synthesized by the in situ polymerization of NIPAM and DMAEMA for the controlled release of doxorubicin hydrochloride (DOX) and N,N ′‐bis(acryloyl)cystamine (BAC) and N,N ′‐methylenebisacrylamide (MBA) act as the crosslinkers, respectively. The structure, size, and zeta potential of PND‐BAC and PND‐MBA were further characterized. Moreover, after loading DOX, the encapsulation efficiency and the in vitro release behavior of PND‐BAC/DOX and PND‐MBA/DOX nanogels were discussed in detail. Compared to PND‐MBA NGs, PND‐BAC nanogels have redox degradability due to the presence of the crosslinker BAC. After loading DOX, the PND‐BAC/DOX nanogel showed a higher encapsulation efficiency (81.6 ± 1.2)% and thermo‐ and pH‐responsiveness as well as redox‐responsive in vitro release. These properties together with excellent environmentally sensitive properties make PND‐BAC as an attractive candidate for application in drug nanocarriers for the targeted drug delivery of model payloads. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 107A: 1195–1203, 2019.

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Xylan-based temperature/pH sensitive hydrogels for drug controlled release

Cited by 113 publications

References 44 publications

Thermosensitive Hydrogel for Encapsulation and Controlled Release of Biocontrol Agents to Prevent Peanut Aflatoxin Contamination

Thermosensitive Hydrogel for Encapsulation and Controlled Release of Biocontrol Agents to Prevent Peanut Aflatoxin Contamination

Synthesis and controlled release of curcumin‐β‐cyclodextrin inclusion complex from nanocomposite poly(N‐isopropylacrylamide/sodium alginate) hydrogels

Preparation of thermo/redox/pH‐stimulative poly(N‐isopropylacrylamide‐co‐N,N′‐dimethylaminoethyl methacrylate) nanogels and their DOX release behaviors

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