Preparation of thermo/redox/pH‐stimulative poly(N‐isopropylacrylamide‐co‐N,N′‐dimethylaminoethyl methacrylate) nanogels and their DOX release behaviors

Abstract

Stimuli‐sensitive drug delivery systems show beneficial features of both medical and pharmaceutical fields. In this article, polymeric nanogel P (N‐isopropylacrylamide–N,N ′‐dimethylaminoethyl methacrylate [NIPAM–DMAEMA]) (PND) with pH/redox/thermo‐responsivenesses was synthesized by the in situ polymerization of NIPAM and DMAEMA for the controlled release of doxorubicin hydrochloride (DOX) and N,N ′‐bis(acryloyl)cystamine (BAC) and N,N ′‐methylenebisacrylamide (MBA) act as the crosslinkers, respectively. The structure, size, and zeta potential of PND‐BAC and PND‐MBA were further characterized. Moreover, after loading DOX, the encapsulation efficiency and the in vitro release behavior of PND‐BAC/DOX and PND‐MBA/DOX nanogels were discussed in detail. Compared to PND‐MBA NGs, PND‐BAC nanogels have redox degradability due to the presence of the crosslinker BAC. After loading DOX, the PND‐BAC/DOX nanogel showed a higher encapsulation efficiency (81.6 ± 1.2)% and thermo‐ and pH‐responsiveness as well as redox‐responsive in vitro release. These properties together with excellent environmentally sensitive properties make PND‐BAC as an attractive candidate for application in drug nanocarriers for the targeted drug delivery of model payloads. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 107A: 1195–1203, 2019.

A Comprehensive Outlook of Synthetic Strategies and Applications of Redox‐Responsive Nanogels in Drug Delivery

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Zn-Co metal organic frameworks coated with chitosand and Au nanoparticles for chemo-photothermal-targeted combination therapy of liver cancer

“…Therefore, several attempts have been made to research a new drug delivery method in recent years, which can achieve high therapeutic efficacy with higher rates of drug loading. The method needs to accurately release drugs upon reaching the target site, must have good biocompatibility and should be environmental friendly ( 10 – 12 ).…”

Novel Temperature/pH/CO2/Redox-Quadruple-Responsive Ferrocene-Containing Homopolymers and Their Self-Assembly Behavior

“…Between them, copolymers have been studied and applied more because of their simple design principle and wide application scope. 6−19 Their types are very rich, for example, temperature/pH, 6−10 temperature/pH/redox, 11,12 O 2 /CO 2 , 13 temperature/pH/ light, 14,15 temperature/pH/oxidation/light, 16,17 and temper-ature/pH/CO 2 /oxidation. 18,19 However, this kind of copolymers usually has some shortcomings: (1) the synthesis or purification steps of copolymers are usually complicated, and the molecular controllability is poor; (2) the response range of a copolymer is generally broad, and the sensitivity is relatively low; (3) due to the incompatibility of each block, it is difficult to systematically study the relationship between different responsiveness and its structure.…”