XRCC1 interactions with multiple DNA glycosylases: A model for its recruitment to base excision repair

Campalans, Anna; Marsin, Stéphanie; Nakabeppu, Yusaku; O’Connor, Timothy; Boiteux, Serge; Radicella, J. Pablo

doi:10.1016/j.dnarep.2005.04.014

Cited by 145 publications

(122 citation statements)

References 33 publications

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“…N-methylpurine DNA glycosylase (MPG) is the general DNA glycosylase for most types of DNA alkylation damage. Recently MPG was reported to interact physically with the human scaffolding protein XRCC1, stimulating activity of MPG and supporting the hypothesis that single-strand alkylation damage is processed via XRCC1 scaffold protein coordination [28].…”

Section: Mono-functional and Bi-functional Dna Glycosylases And Ap-simentioning

confidence: 67%

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A unified view of base excision repair: Lesion-dependent protein complexes regulated by post-translational modification

Almeida¹,

Sobol²

2007

DNA Repair

379

374

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Base excision repair (BER) proteins act upon a significantly broad spectrum of DNA lesions that result from endogenous and exogenous sources. Multiple sub-pathways of BER (short-path or longpatch) and newly designated DNA repair pathways (e.g., SSBR and NIR) that utilize BER proteins complicate any comprehensive understanding of BER and its role in genome maintenance, chemotherapeutic response, neurodegeneration, cancer or aging. Herein, we propose a unified model of BER, comprised of three functional processes: Lesion Recognition/Strand Scission, Gap Tailoring and DNA Synthesis/Ligation, each represented by one or more multiprotein complexes and coordinated via the XRCC1/DNA Ligase III and PARP1 scaffold proteins. BER therefore may be represented by a series of repair complexes that assemble at the site of the DNA lesion and mediates repair in a coordinated fashion involving protein-protein interactions that dictate subsequent steps or sub-pathway choice. Complex formation is influenced by post-translational protein modifications that arise from the cellular state or the DNA damage response, providing an increase in specificity and efficiency to the BER pathway. In this review, we have summarized the reported BER proteinprotein interactions and protein post-translational modifications and discuss the impact on DNA repair capacity and complex formation.

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Section: Mono-functional and Bi-functional Dna Glycosylases And Ap-simentioning

confidence: 67%

“…In the past several years, XRCC1 coordination was further expanded to include pathway initiation enzymes (e.g. ; MPG, OGG1 and NEIL2) as well as APE1, firmly establishing XRCC1 in the orchestration of the entire BER pathway [23,28,34,40]. Thus, XRCC1 interacts with most, if not all components of the BER short-patch pathway.…”

Section: Scaffold Proteinsmentioning

confidence: 99%

A unified view of base excision repair: Lesion-dependent protein complexes regulated by post-translational modification

Almeida¹,

Sobol²

2007

DNA Repair

379

374

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“…While the protein encoded by XRCC1 has no known enzymatic activity, it is thought to act as a scaffold protein which coordinates the activities of other proteins such as DNA polymerase β, DNA ligase III, and poly (ADP-ribose) polymerase (PARP), which function at the site of DNA damage (Campalans et al, 2005) by recognizing and binding to single-strand breaks (Dalhus et al, 2009). The XRCC1 Arg399Gln polymorphism is located within the XRCC1 BRCA1 carboxyl-terminal domain (BRCT I) and is suggested to affect protein structure and function.…”

Section: Discussionmentioning

confidence: 99%

Single Nucleotide Polymorphisms of DNA Base-excision Repair Genes (APE1, OGG1 and XRCC1) Associated with Breast Cancer Risk in a Chinese Population

Luo¹,

Li²,

Qu³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Altered DNA repair capacity can result in increased susceptibility to cancer. The base excision repair (BER) pathway effectively removes DNA damage caused by ionizing radiation and reactive oxidative species (ROS). In the current study, we analyzed the possible relation of polymorphisms in BER genes, including 8-oxoguanine DNA glycosylase (OGG1), apurinic/apyrimidinic endonuclease 1 (APE1), and X-ray repair cross-complementing group 1 protein (XRCC1), with breast cancer risk in Chinese Han women. This case-control study examined 194 patients with breast cancer and 245 cancer-free hospitalized control subjects. Single nucleotide polymorphisms (SNPs) of OGG1 (Ser326Cys), XRCC1 (Arg399Gln), and APE1 (Asp148Glu and -141T/G) were genotyped and analyzed for their association with breast cancer risk using multivariate logistic regression models. We found that XRCC1 Arg399Gln was significantly associated with an increased risk of breast cancer. Similarly, the XRCC1 Gln allele was significantly associated with an elevated risk in postmenopausal women and women with a high BMI (≥ 24 kg/m 2 ). The OGG1 Cys allele provided a significant protective effect against developing cancer in women with a low BMI (< 24 kg/m 2 ). When analyzing the combined effects of these alleles on the risk of breast cancer, we found that individuals with ≥ 2 adverse genotypes (XRCC1 399Gln, APE1 148Asp, and OGG1 326Ser) were at a 2.18-fold increased risk of breast cancer (P = 0.027). In conclusion, our data indicate that Chinese women with the 399Gln allele of XRCC1 have an increased risk of breast cancer, and the combined effects of polymorphisms of BER genes may contribute to tumorigenesis.

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“…Base excision repair (BER) pathway is the key mechanism involved in repairing small base lesions in DNA that are the result of oxidation and alkylation damage (Hoeijmakers, 2001;Mahimkar et al, 2012), and was closely associated with lung cancer development (Qian and Massion, 2008). SNPs in susceptible genes have been increasingly emphasized on the grounds that XRCC1 is considered a crucial scaffold protein closely associated with the base excision repair pathway (Campalans et al, 2005). It serves as a scaffold protein in both single-strand break repair and base excision repair activities (Lindahl et al, 1999).…”

Section: Discussionmentioning

confidence: 99%

No Association of XRCC1 and CLPTM1L Polymorphisms with Non-small Cell Lung Cancer in a Non-Smoking Han Chinese Population

Sun¹,

Zhang²,

Kong³

2013

Asian Pacific Journal of Cancer Prevention

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Background: This study aimed to explore potential associations between single nucleotide polymorphisms (SNPs) of the x-ray repair cross-complementing group 1 (XRCC1) and cleft lip and palate transmembrane protein 1-like (CLPTM1L) and non-small cell lung cancer (NSCLC) susceptibility in non-smoker Chinese patients. Methods: A total of 200 NSCLC patients and 200 healthy controls with matched age and gender were recruited for genotyping of XRCC1 SNPs (rs2256507 and rs1001581) and CLPTM1L SNPs (rs401681 and rs4975616). Association of these SNPs with NSCLC risk was evaluated by computing the odds ratio (OR) and 95% confidence interval (CI) from multivariate unconditional logistic regression analyses with adjustment for gender and age. Results: The frequencies of genotype and allele in these four loci (rs2256507, rs1001581, rs401681, and rs4975616) were not significantly different between the cases and controls, or between either of the histological subgroups (adenocarcinoma and squamous cell carcinoma) and controls. Conclusions: Although these SNPs are associated with NSCLC risk in patients with a tobacco-smoking habit, this study demonstrated that XRCC1 and CLPTM1L gene SPNs are not linked with NSCLC risk in non-smoking patients, indicating that molecular mechanisms of NSCLC betwee tobacco smokers and non-smokers may be different. Future studies are needed to uncover the underlying molecular mechanisms for NSCLC in non-smokers.

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XRCC1 interactions with multiple DNA glycosylases: A model for its recruitment to base excision repair

Cited by 145 publications

References 33 publications

A unified view of base excision repair: Lesion-dependent protein complexes regulated by post-translational modification

A unified view of base excision repair: Lesion-dependent protein complexes regulated by post-translational modification

Single Nucleotide Polymorphisms of DNA Base-excision Repair Genes (APE1, OGG1 and XRCC1) Associated with Breast Cancer Risk in a Chinese Population

No Association of XRCC1 and CLPTM1L Polymorphisms with Non-small Cell Lung Cancer in a Non-Smoking Han Chinese Population

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