XRCC1 and ADPRT Polymorphisms Associated with Survival in Breast Cancer Cases Treated with Chemotherapy

Rong, Jianhui; Huang, Shaohong; Zheng, Zhousan; Miao, Yun; Wang, Shenming

doi:10.7314/apjcp.2012.13.10.4923

Cited by 6 publications

(6 citation statements)

References 28 publications

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“…In the current study, we demonstrated that XRCC1 played a crucial role in repairing melphalan‐induced DNA damage in MM cells and a specific variation in XRCC1 gene, rs25487, was significantly associated with PFS in MM patients with ASCT‐HDM. These results are consistent with previous studies showing that XRCC1 rs25487 A mutant allele was associated with longer PFS or OS in breast cancer patients, non–small‐cell lung carcinoma patients, and nasopharyngeal carcinoma patients with chemotherapy or radiotherapy alone or with concomitant radiotherapy and chemotherapy . More interestingly, our results also showed that the association between XRCC1 rs25487 and PFS was independent of the known associations of risk level and ANRIL rs2151280 with PFS, suggesting that XRCC1 rs25487, ANRIL rs2151280, and risk level may be independent predictors of clinical outcomes in MM patients with ASCT‐HDM.…”

Section: Discussionsupporting

confidence: 93%

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XRCC1‐mediated DNA repair is associated with progression‐free survival of multiple myeloma patients after autologous stem cell transplant

Persaud

Johnson

Seligson

et al. 2019

Molecular Carcinogenesis

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Autologous stem cell transplant (ASCT) with high‐dose melphalan (HDM) is the standard treatment for fit multiple myeloma (MM) patients. It is generally believed that some DNA repair proteins impact the activity to repair melphalan‐induced DNA damage, thus potentially contributing to the patient's clinical response. However, knowledge of these proteins is limited. In the current study, we investigated the roles of XRCC1, a protein involved in base excision repair and single‐strand break repair, in melphalan response in MM cells. Small interfering RNA knockdown of XRCC1 significantly increased the accumulation of melphalan‐induced DNA damage in MM cells and sensitized them to melphalan treatment, indicating that genetic variation in XRCC1 may impact response to melphalan treatment. We then evaluated the association between an XRCC1 variant with reduced activity, rs25487 (R399Q), and clinical outcomes of 108 MM patients with melphalan therapy. Our results showed that XRCC1 rs25487 was associated with prolonged progression‐free survival (PFS) in MM patients. The adjusted hazard ratio for PFS between patients carrying rs25487 AA/AG and GG was 0.42 (95% confidence interval: 0.25, 0.84, P = .014). Taken together, these results indicate that XRCC1 is involved in the repair of melphalan‐induced DNA damage and XRCC1 rs25487 variant with impaired DNA repair function influences the clinical responses of HDM in MM patients.

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Section: Discussionsupporting

confidence: 93%

“…Furthermore, carriers of XRCC1 R399Q have been associated with an increase of chromosomal deletions . Additionally, rs25487 A variant allele was associated with longer PFS or overall survival (OS) in breast cancer, non–small‐cell lung carcinoma, and nasopharyngeal carcinoma patients receiving standard chemotherapy …”

Section: Introductionmentioning

confidence: 99%

XRCC1‐mediated DNA repair is associated with progression‐free survival of multiple myeloma patients after autologous stem cell transplant

Persaud

Johnson

Seligson

et al. 2019

Molecular Carcinogenesis

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“…In this study, we have no statistical evident to associate the variant in XRCC1 rs1799782 and rs25487 SNPs to breast cancer risk in Malaysian women but latest metaanalysis studies showed that variant in both SNPs were significantly increased the risk of breast cancer (Wu et al, 2011;Liu et al, 2013;Bu et al, 2014;Feng et al, 2014). Interestingly, a study conducted by Ye et al revealed that breast cancer patients with Gln/Gln genotype in XRCC1 rs25487 SNP were associated with a longer survival rate after chemotherapy treatment when compared to wildtype genotype (Ye et al, 2012), indicating the prognostic value of this SNP in breast cancer patients receiving chemotherapy.…”

Section: 647 Association Of Cyp2e1 Stk15 and Xrcc1 Polymorphisms Wimentioning

confidence: 99%

Association of CYP2E1, STK15 and XRCC1 Polymorphisms with Risk of Breast Cancer in Malaysian Women

Chong

Goh²,

See³

et al. 2016

Asian Pacific Journal of Cancer Prevention

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Background: Breast cancer is the most common type of cancer affecting Malaysian women. Recent statistics revealed that the cumulative probability of breast cancer and related deaths in Malaysia is higher than in most of the countries of Southeast Asia. Single nucleotide polymorphisms (SNPs) in CYP2E1 (rs6413432 and rs3813867), STK15 (rs2273535 and rs1047972) and XRCC1 (rs1799782 and rs25487) have been associated with breast cancer risk in a meta-analysis but any link in Southeast Asia, including Malaysia, remained to be determined. Hence, we investigated the relationship between these SNPs and breast cancer risk among Malaysian women in the present case-control study. Materials and Methods: Genomic DNA was isolated from peripheral blood of 71 breast cancer patients and 260 healthy controls and subjected to polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis. Results: Our study showed that the c1/c2 genotype or subjects with at least one c2 allele in CYP2E1 rs3813867 SNP had significantly increased almost 1.8-fold higher breast cancer risk in Malaysian women overall. In addition, the variant Phe allele in STK15 rs2273535 SNP appeared to protect against breast cancer in Malaysian Chinese. No significance association was found between XRCC1 SNPs and breast cancer risk in the population. Conclusions: This study provides additional knowledge on CYP2E1, STK15 and XRCC1 SNP impact of risk of breast cancer, particularly in the Malaysian population. From our findings, we also recommend Malaysian women to perform breast cancer screening before 50 years of age.Keywords: Breast cancer -CYP2E1 -Malaysian women -single nucleotide polymorphisms -STK15 -XRCC1

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“…The genetic reports connecting the association of 762Val/Ala of ADPRT gene with OS and DFS are also limited. Ye et al observed slightly decreased survival among 762Ala/Ala individuals. Our outcomes pointed out that the presence of the 762Ala/Ala genotype may significantly decrease survival in relation to chemotherapy alone and radiotherapy alone.…”

Section: Discussionmentioning

confidence: 96%

The role of base excision repair in pathogenesis of breast cancer in the Polish population

Cuchra

Mucha

Markiewicz

et al. 2015

Molecular Carcinogenesis

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Breast cancer (BC) is leading type of cancer among group of women, which determines almost 23% of invasive cancers. It has been reported repeatedly that the level of oxidative stress is higher for BC in comparison to cancer-free woman. The goal of the present study was to evaluate the role of base excision repair (BER) pathway in the development of BC. One-hundred seventy-one women with confirmed BC and 222 healthy controls were enrolled in presented study. The level of oxidative DNA damage and the kinetic of their repair were analyzed by the modified alkaline comet assay. The efficiency of BER pathway was evaluated by BER assay. The presence of the 326Cys/Cys genotype and 326Cys allele of OGG1 gene and the 324His/His of MUTYH gene are associated with increased risk of BC development. Moreover, correlation between clinical parameter with selected genes has shown increased risk of BC progression. The survival analysis has shown a significant lower DFS for individuals with the 762Ala/Ala genotype compared to 762Val/Vla carriers and the 762Val/Ala genotype in relation to concomitant chemotherapy and radiotherapy. In subgroup of patients with alone chemotherapy and alone radiotherapy, the 762Val/Val genotype was significantly associated with lower overall survival. Furthermore, we also elevated the level of basal and oxidative DNA damage in a group of patients with BC in relation to healthy controls. We also observed the difference in effectiveness of DNA damage repair. The results of present studies suggested the important role of BER pathway in BC development. © 2015 Wiley Periodicals, Inc.

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XRCC1 and ADPRT Polymorphisms Associated with Survival in Breast Cancer Cases Treated with Chemotherapy

Cited by 6 publications

References 28 publications

XRCC1‐mediated DNA repair is associated with progression‐free survival of multiple myeloma patients after autologous stem cell transplant

XRCC1‐mediated DNA repair is associated with progression‐free survival of multiple myeloma patients after autologous stem cell transplant

Association of CYP2E1, STK15 and XRCC1 Polymorphisms with Risk of Breast Cancer in Malaysian Women

The role of base excision repair in pathogenesis of breast cancer in the Polish population

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