Xiexin Tang ameliorates dyslipidemia in high-fat diet-induced obese rats via elevating gut microbiota-derived short chain fatty acids production and adjusting energy metabolism

Xiao, Suwei; Zhang, Zhimiao; Chen, Mengjun; Zou, Junfeng; Jiang, Shu; Qian, Dawei; Duan, Jin‐Ao

doi:10.1016/j.jep.2019.112032

Cited by 55 publications

(40 citation statements)

References 57 publications

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“…MET shifts gut microbiota composition through the enrichment of mucin-degrading A.muciniphila as well as several SCFAproducing microbiota. SCFAs served as one of the energy resources that play a critical role in the cardiovascular system [81]. In this study, we consider the impact of notable increases of SCFAs with MET administration on the attenuation of AS may probably rely on the suppression of inflammation via binding to G-protein coupled receptor (GPR)41 or GPR43 receptors on Mψs [82].…”

Section: Plos Onementioning

confidence: 99%

Metformin intervention ameliorates AS in ApoE-/- mice through restoring gut dysbiosis and anti-inflammation

Ning

Wang

et al. 2021

PLoS ONE

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Atherosclerosis (AS) is closely associated with chronic low-grade inflammation and gut dysbiosis. Metformin (MET) presents pleiotropic benefits in the control of chronic metabolic diseases, but the impacts of MET intervention on gut microbiota and inflammation in AS remain largely unclear. In this study, ApoE-/- mice with a high-fat diet (HFD) were adopted to assess the MET treatment. After 12 weeks of MET intervention (100mg·kg-1·d-1), relevant indications were investigated. As indicated by the pathological measurements, the atherosclerotic lesion was alleviated with MET intervention. Moreover, parameters in AS including body weights (BWs), low-density lipoprotein (LDL), triglyceride (TG), total cholesterol (TC) and malondialdehyde (MDA) were elevated; whereas high-density lipoprotein (HDL) and total superoxide dismutase (T-SOD) levels were decreased, which could be reversed by MET intervention. Elevated pro-inflammatory interleukin (IL)-1β, IL-6, tumor necrosis factor (TNF)-α and lipopolysaccaride (LPS) in AS were decreased after MET administration. However, anti-inflammatory IL-10 showed no significant difference between AS group and AS+MET group. Consistently, accumulated macrophages in the aorta of AS were conversely lowered with MET treatment. The results of 16S rRNA sequencing and analysis displayed that the overall community of gut microbiota in AS was notably changed with MET treatment mainly through decreasing Firmicutes, Proteobacteria, Romboutsia, Firmicutes/Bacteroidetes, as well as increasing Akkermansia, Bacteroidetes, Bifidobacterium. Additionally, we found that microbiota-derived short-chain fatty acids (SCFAs) including acetic acid, propionic acid, butyric acid and valeric acid in AS were decreased, which were significantly up-regulated with MET intervention. Consistent with the attenuation of MET on gut dysbiosis, decreased intestinal tight junction protein zonula occludens-1 (ZO)-1 in AS was restored after MET supplementation. Correlation analysis showed close relationships among gut bacteria, microbial metabolites SCFAs and inflammation. Collectively, MET intervention ameliorates AS in ApoE-/- mice through restoring gut dysbiosis and anti-inflammation, thus can potentially serve as an inexpensive and effective intervention for the control of the atherosclerotic cardiovascular disease.

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Section: Plos Onementioning

confidence: 99%

Metformin intervention ameliorates AS in ApoE-/- mice through restoring gut dysbiosis and anti-inflammation

Ning

Wang

et al. 2021

PLoS ONE

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“…32 The Xiexin decoction can also upregulate AMPK, inhibit SREBPs, downregulate the expression of ACC and fatty acid synthase (FAS), and reduce fat production. 16 The white tiger plus ginseng decoction can induce the activation of AMPK, inhibit the expression of ACC, and reduce the synthesis and accumulation of lipids. 21…”

Section: Inhibit Fat Production and Accumulationmentioning

confidence: 99%

“…50 The Xiexin decoction reduces weight by increasing the level and activity of key enzyme mRNAs involved in SCFA synthesis (acetate kinase (ACK), methylmalonyl-CoA decarboxylase (MMD), butyryl-CoA: acetate CoA transferase (BUT) and butyrate kinase (BUK)) and increasing the abundance of intestinal microflora. 16…”

Section: Increase the Level Of Scfasmentioning

confidence: 99%

“…Traditional Chinese medicine has been used for a long time for treating diseases, playing an important role in the treatment of obesity. 10,11 In this paper, we selected drugs that have been widely discussed in obesity-related metabolic studies and can be used in clinical practice without obvious toxic and side effects, such as ginsenoside (Ginseng), 12 celastrol (Tripterygium wilfordii), 13 berberine (Coptis chinensis), 14 curcumin (Turmeric), 15 and the Xiexin 16 and Danggui Buxue decoctions. 17 Considering that different organ tissues may play similar weight-reducing roles under the role of TCM or TCM extracts in the weight-reducing process, we will mainly generalize from the specific mechanisms (regulating fat metabolism, intestinal Microflora, and regulating hormone level, etc.…”

Section: Introductionmentioning

confidence: 99%

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<p>The Mechanism of Traditional Chinese Medicine for the Treatment of Obesity</p>

Li¹,

Zhang²,

Li³

2020

DMSO

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Obesity is the lipid deposition caused by the imbalance between energy intake and consumption caused by a variety of factors. Obesity can lead to multiple systemic complications. At present, the treatment of obesity is mainly lifestyle intervention, drug weight loss, and weight loss surgery, but the curative effect is limited or the side effects are serious. Traditional Chinese medicine plays a unique role in the treatment of obesity. Existing studies have found that traditional Chinese medicine can treat obesity in a variety of ways, such as regulating intestinal microflora, enhancing hormone level, regulating fat metabolism, and so on. In this review, we will introduce and summarize the mechanism of traditional Chinese medicine in the treatment of obesity.

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“…It is a common medicine for treating cold, flu, fever, diarrhea, jaundice, headache, abdominal pain, drenching, etc. SB is frequently used in classical prescription, such as Mahuang Shengma decoction, Xiexin decoction and Huangqin decoction, ect [ 10 ]. In modern clinical applications, the quantity or dosage of TCM in prescriptions can be added or reduced to clearing away heat with different symptoms [ 11 ].…”

Section: Applicationsmentioning

confidence: 99%

Applications, phytochemistry, pharmacological effects, pharmacokinetics, toxicity of Scutellaria baicalensis Georgi. and its probably potential therapeutic effects on COVID-19: a review

et al. 2020

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Scutellaria baicalensis Georgi. (SB) is a common heat-clearing medicine in traditional Chinese medicine (TCM). It has been used for thousands of years in China and its neighboring countries. Clinically, it is mostly used to treat diseases such as cold and cough. SB has different harvesting periods and processed products for different clinical symptoms. Botanical researches proved that SB included in the Chinese Pharmacopoeia (1st, 2020) was consistent with the medicinal SB described in ancient books. Modern phytochemical analysis had found that SB contains hundreds of active ingredients, of which flavonoids are its major components. These chemical components are the material basis for SB to exert pharmacological effects. Pharmacological studies had shown that SB has a wide range of pharmacological activities such as antiinflammatory, antibacterial, antiviral, anticancer, liver protection, etc. The active ingredients of SB were mostly distributed in liver and kidney, and couldn't be absorbed into brain via oral absorption. SB’s toxicity was mostly manifested in liver fibrosis and allergic reactions, mainly caused by baicalin. The non-medicinal application prospects of SB were broad, such as antibacterial plastics, UV-resistant silk, animal feed, etc. In response to the Coronavirus Disease In 2019 (COVID-19), based on the network pharmacology research, SB’s active ingredients may have potential therapeutic effects, such as baicalin and baicalein. Therefore, the exact therapeutic effects are still need to be determined in clinical trials. SB has been reviewed in the past 2 years, but the content of these articles were not comprehensive and accurate. In view of the above, we made a comprehensive overview of the research progress of SB, and expect to provide ideas for the follow-up study of SB.

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Xiexin Tang ameliorates dyslipidemia in high-fat diet-induced obese rats via elevating gut microbiota-derived short chain fatty acids production and adjusting energy metabolism

Cited by 55 publications

References 57 publications

Metformin intervention ameliorates AS in ApoE-/- mice through restoring gut dysbiosis and anti-inflammation

Metformin intervention ameliorates AS in ApoE-/- mice through restoring gut dysbiosis and anti-inflammation

<p>The Mechanism of Traditional Chinese Medicine for the Treatment of Obesity</p>

Applications, phytochemistry, pharmacological effects, pharmacokinetics, toxicity of Scutellaria baicalensis Georgi. and its probably potential therapeutic effects on COVID-19: a review

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