&lt;p&gt;The Mechanism of Traditional Chinese Medicine for the Treatment of Obesity&lt;/p&gt;

Li, Chang; Zhang, Hongli; Li, Xiaohua

doi:10.2147/dmso.s274534

Cited by 19 publications

(19 citation statements)

References 96 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The most principal medicinal plants and herbs in traditional Chinese medicine in the treatment of obesity are celastrol (Tripterygium wilfordii), Berberine (Coptis chinensis), Capsaicin (Chili pepper), Resveratrol (Polygonum cuspidatum), Chrysophanic acid/Rhein (Rhubarb), Fenugreek (Trigonella foenumgraecum L.), Curcumin (Turmeric), Radix astragali, Tea catechins GTpolyphenols (Green tea), Xiexin decoction, white tiger plus ginseng decoction, and Chaihu Shugan powder through increased leptin sensitivity, blocking fat production and accumulation, improving lipid decomposition, regulating the level of adiponectin, etc. [231,232]. Polyphenol, quercetin, caffeic acid, hydroxyflavin, and hesperetin are active constituents of mulberry leaf with possible anti-obesity impacts [233].…”

Section: Solanaceaementioning

confidence: 99%

Natural Dietary and Medicinal Plants with Anti-Obesity Therapeutics Activities for Treatment and Prevention of Obesity during Lock Down and in Post-COVID-19 Era

2021

View full text Add to dashboard Cite

Overweight and obesity have become global epidemics, especially during the lockdown due to the COVID-19 pandemic. The potential of medicinal plants as a better and safe option in treating obesity and overweight has gained attention in recent years. Obesity and overweight has become a major public health concern, and its incidence rising at an alarming rate. Obesity is one of the major types of metabolic syndrome, resulting in various types of problems such as hypertension, diabetes, dyslipidemia, and excess fat accumulation. The current searching was done by the keywords in main indexing systems including Scopus, PubMed/MEDLINE, the search engine of Google Scholar, and Institute for Scientific Web of Science. The keywords were traditional medicine, health benefits, pharmaceutical science, pomegranate, punicalin, punicalagin, and ellagitannins. Google Scholar was searched manually for possible missing manuscripts, and there was no language restriction in the search. This review was carried out to highlight the importance of medicinal plants which are common in traditional medicinal sciences of different countries, especially Asia to prevent and treatment of obesity and overweight during the global pandemic and the post-COVID-19 era.

show abstract

Section: Solanaceaementioning

confidence: 99%

Natural Dietary and Medicinal Plants with Anti-Obesity Therapeutics Activities for Treatment and Prevention of Obesity during Lock Down and in Post-COVID-19 Era

2021

View full text Add to dashboard Cite

show abstract

“…The complicated pathophysiological mechanism of NAFLD restricts the e cacy of the application of a single agent. Traditional Chinese Medicine (TCM) has been commonly used to treat hepatic disease and metabolic disorders-related obesity and type 2 diabetes mellitus [24][25][26]. The therapeutic effect of TCM on NAFLD mainly focused on the holistic regulations including lipid metabolism modulation, antioxidative stress, anti-in ammation, and gut microbiota modulation [27][28][29].…”

Section: Introductionmentioning

confidence: 99%

Investigation of the potential mechanism of the Shugan Xiaozhi decoction for the treatment of nonalcoholic fatty liver disease based on network pharmacology and molecular docking

Xing

Yang

et al. 2022

Preprint

View full text Add to dashboard Cite

Background: Nonalcoholic fatty liver disease (NAFLD) is a metabolic-related disease with its incidence increasing annually. Shugan Xiaozhi (SGXZ) decoction, a composite traditional Chinese medicinal prescription, was demonstrated to exert a therapeutic effect on NAFLD. However, the underlying mechanisms were incompletely elucidated. In this study, the potential bioactive ingredients and mechanism of the SGXZ decoction against NAFLD were explored via network pharmacology and molecular docking. Methods: Compounds in SGXZ decoction were identified and collected from literature studies, and the corresponding targets were predicted through SEA database. Potential targets related to NAFLD were overlapped by using DisGeNET and GeneCards database. The compound-target-disease and PPI network were then constructed based on the putative intersection targets of SGXZ decoction and NAFLD to recognize the key compounds and targets. Functional enrichment analysis was performed to elucidate the biological process and signaling pathway that SGXZ decoction treated NAFLD. Finally, molecular docking combined with homology modeling was applied to further verify the binding between key active compounds and targets.Results: A total of 31 active compounds and 220 corresponding targets in SGXZ decoction were collected. Moreover, 1544 overlapped targets of NAFLD were obtained, of which 78 common targets were intersected with targets of SGXZ decoction. Key compounds and targets were recognized from compound-target-disease and PPI network. Functional enrichment analysis revealed that multiple biological pathways were annotated including insulin resistance, HIF-1, PI3K-Akt, and MAPK signaling pathways. Molecular docking confirmed that gallic acid, chlorogenic acid and isochlorogenic acid A could combine firmly with all of the key targets. Conclusion: SGXZ decoction could produce a promising effect for its multi-component, multi-target and multi-biological process in the treatment of NAFLD. The present study provides the novel insight into a comprehensive understanding for further study.

show abstract

“… 8 He Xuewei and Hu Qiming used Qiwei Baizhu Powder to treat patients T2DM displaying spleen deficiency with dampness. The results after four weeks of treatment indicated that Qiwei Baizhu Powder can alleviate symptoms (depression, fatigue, and head and body distress), reduce fasting and postprandial blood glucose spikes, and increase the levels 9 of glucagon-like peptide-1 (GLP-1) in patients. This reflects the role of gastrointestinal hormones in regulating blood sugar, providing a new theoretical basis for spleen deficiency resulting in diabetes and greatly aiding the understanding 10 of TCM in relation to T2DM.…”

Section: Introductionmentioning

confidence: 99%

The Distribution Pattern of Traditional Chinese Medicine Syndromes in 549 Patients with Type 2 Diabetes

Zhang¹,

Liu²,

Liang³

et al. 2021

DMSO

View full text Add to dashboard Cite

Objective This study aimed to summarize the distribution pattern of traditional Chinese medicine (TCM) syndromes in patients with type 2 diabetes mellitus (T2DM). Methods The frequency, characteristics and distribution of all TCM syndromes of 549 patients with T2DM were analyzed. Results The average age of T2DM onset was higher in women than in men (ie, men experienced earlier onset). The distribution of TCM syndromes, in order of frequency, was as follows: damp-heat trapping spleen (including spleen deficiency and dampness, damp heat due to spleen deficiency, and qi weakness due to spleen deficiency) (58.29%), qi-yin deficiency (16.03%), deficiency of yin and excessive heat (12.93%), blood stasis in collaterals (9.41%), and yin-yang deficiency (3.21%). The physical intensity of patients’ occupational activity was mainly light (49.6%), followed by heavy (31.4%) and moderate (19.0%). Conclusion Damp-heat trapping spleen is the most common TCM syndrome in patients with T2DM, with damp heat due to spleen deficiency the most significant subtype. This syndrome tends to occur in people over the age of 60 and those undertaking too much or too little physical activity in their occupational activities. The traditional “three more and one less” symptoms do not adequately describe the clinical symptoms of T2DM.

show abstract

<p>The Mechanism of Traditional Chinese Medicine for the Treatment of Obesity</p>

Cited by 19 publications

References 96 publications

Natural Dietary and Medicinal Plants with Anti-Obesity Therapeutics Activities for Treatment and Prevention of Obesity during Lock Down and in Post-COVID-19 Era

Natural Dietary and Medicinal Plants with Anti-Obesity Therapeutics Activities for Treatment and Prevention of Obesity during Lock Down and in Post-COVID-19 Era

Investigation of the potential mechanism of the Shugan Xiaozhi decoction for the treatment of nonalcoholic fatty liver disease based on network pharmacology and molecular docking

The Distribution Pattern of Traditional Chinese Medicine Syndromes in 549 Patients with Type 2 Diabetes

Contact Info

Product

Resources

About