Xiaozhang Tie Improves Intestinal Motility in Rats With Cirrhotic Ascites by Regulating the Stem Cell Factor/c-kit Pathway in Interstitial Cells of Cajal

Zhao, Qiang; Feng, Xing; Yue, Tao; Liu, Hongliang; Huang, Kai; Peng, Yuan; Feng, Nianping; Liu, Chenghai

doi:10.3389/fphar.2020.00001

Cited by 208 publications

(151 citation statements)

References 14 publications

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“…Furthermore, the virulence mechanism and pathogenicity of SARS-CoV2 is associated with the non-structural and structural proteins via blocking host innate immune response and by mediating viral assembly and release, successively [ 29 , 32 ]. In CoV genome, NSP3 is the largest protein and it possesses several domain activities essential for CoV replication [ 31 ].…”

Section: Molecular Mechanism and Genetic Diversity Of Sars-cov2mentioning

confidence: 99%

“…Recent work reported that the respiratory droplets are associated with the contact of SARS-CoV2 transmission. It also stated that transmission occurs through airborne droplets and with close contact with each other [ 38 , 40 ]. It is important to mention that asymptomatic COVID-19 patient is also in the transmission process.…”

Section: Transmission Of Sars-cov2mentioning

confidence: 99%

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Genetic Diversity of SARS-CoV2 and Environmental Settings: Possible Association with Neurological Disorders

et al. 2021

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Section: Molecular Mechanism and Genetic Diversity Of Sars-cov2mentioning

confidence: 99%

Section: Transmission Of Sars-cov2mentioning

confidence: 99%

Genetic Diversity of SARS-CoV2 and Environmental Settings: Possible Association with Neurological Disorders

et al. 2021

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“…23 TDM involves measuring the patient’s blood or plasma drug levels at the specified time to guide the dosage regimen needed to maintain levels of therapeutic ranges. 24 By combining pharmaceutical, pharmacokinetics, and pharmacodynamic knowledge, TDM enables the assessment of certain drugs’ efficacy and safety. 25 In particular, TDM provides rational support for the translation of doses to patient individual characteristics and contributes to optimizing the design of a critical phase III clinical trials, where the success of this phase represents the main conditions for drug marketing approval.…”

Section: Therapeutic Drug Monitoring (Tdm) In Generalmentioning

confidence: 99%

“… 25 In particular, TDM provides rational support for the translation of doses to patient individual characteristics and contributes to optimizing the design of a critical phase III clinical trials, where the success of this phase represents the main conditions for drug marketing approval. 24 …”

Section: Therapeutic Drug Monitoring (Tdm) In Generalmentioning

confidence: 99%

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Volumetric Absorptive Microsampling as a Sampling Alternative in Clinical Trials and Therapeutic Drug Monitoring During the COVID-19 Pandemic: A Review

Harahap¹,

Diptasaadya²,

Purwanto³

2020

DDDT

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An infectious disease, COVID-19, caused by a new type of coronavirus, has been discovered recently. This disease can cause respiratory distress, fever, and fatigue. It still has no drug and vaccine for treatment and prevention. Therefore, WHO recommends that people should stay at home to reduce disease transmission. Due to the quarantine, FDA stated that this could hamper drug development clinical trial protocols. Hence, an alternative sampling method that can be applied at home is needed. Currently, volumetric absorptive microsampling (VAMS) has become attention in its use in clinical and bioanalytical fields. This paper discusses the advantages and challenges that might be found in the use of VAMS as an alternative sampling tool in clinical trials and therapeutic drug monitoring (TDM) during the COVID-19 pandemic. VAMS allows easy sampling, can be done at home, storage and delivery at room temperature, and the volume taken is small and minimally invasive. VAMS is also able to absorb a fixed volume that can increase the accuracy and precision of analytical methods, and reduce the hematocrit effects (HCT). The use of VAMS is expected to be implemented immediately in clinical trials and TDM during this pandemic considering the benefits it has.

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Medical Applications of Porous Biomaterials: Features of Porosity and Tissue‐Specific Implications for Biocompatibility

Hernandez

Woodrow

2022

Adv Healthcare Materials

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Porosity is an important material feature commonly employed in implants and tissue scaffolds. The presence of material voids permits the infiltration of cells, mechanical compliance, and outward diffusion of pharmaceutical agents. Various studies have confirmed that porosity indeed promotes favorable tissue responses, including minimal fibrous encapsulation during the foreign body reaction (FBR). However, increased biofilm formation and calcification is also described to arise due to biomaterial porosity. Additionally, the relevance of host responses like the FBR, infection, calcification, and thrombosis are dependent on tissue location and specific tissue microenvironment. In this review, the features of porous materials and the implications of porosity in the context of medical devices is discussed. Common methods to create porous materials are also discussed, as well as the parameters that are used to tune pore features. Responses toward porous biomaterials are also reviewed, including the various stages of the FBR, hemocompatibility, biofilm formation, and calcification. Finally, these host responses are considered in tissue specific locations including the subcutis, bone, cardiovascular system, brain, eye, and female reproductive tract. The effects of porosity across the various tissues of the body is highlighted and the need to consider the tissue context when engineering biomaterials is emphasized.

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Xiaozhang Tie Improves Intestinal Motility in Rats With Cirrhotic Ascites by Regulating the Stem Cell Factor/c-kit Pathway in Interstitial Cells of Cajal

Abstract: amount of ascites and improved intestinal motility in cirrhotic rats, which may be associated with its effect on ascites and was involved in the mechanisms regulating the SCF/c-kit signaling pathway in ICCs and improving gastrointestinal hormone secretion.

Cited by 208 publications

References 14 publications

Genetic Diversity of SARS-CoV2 and Environmental Settings: Possible Association with Neurological Disorders

Genetic Diversity of SARS-CoV2 and Environmental Settings: Possible Association with Neurological Disorders

Volumetric Absorptive Microsampling as a Sampling Alternative in Clinical Trials and Therapeutic Drug Monitoring During the COVID-19 Pandemic: A Review

Medical Applications of Porous Biomaterials: Features of Porosity and Tissue‐Specific Implications for Biocompatibility

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