XI. A dry pollen ophthalmic test in pollen asthma and hay fever patients negative to cutaneous tests

Peshkin, M. Murray

doi:10.1016/s0021-8707(31)90263-3

Cited by 39 publications

(9 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Subsequently, CAC has been widely used to detect sensitivity to aeroallergens [21,31,32]. These studies suggested that CAC was helpful both in determining the etiology and diagnosis and therapy monitoring [29].…”

Section: Discussionmentioning

confidence: 99%

Clinical Value of Conjunctival Allergen Challenge in Diagnosing Allergic Conjunctivitis Related to Latex

Chełmińska

Niedoszytko

Jassem³

2010

Int Arch Allergy Immunol

View full text Add to dashboard Cite

Background: The clinical value of conjunctival allergen challenge (CAC) with latex allergen in patients with allergic conjunctivitis remains undefined. The aim of this study was to assess the value of conjunctival allergen challenge with latex extract in a group of patients with latex sensitization and a history of conjunctivitis after contact with latex products. Methods: Fifty patients who had symptoms of conjunctivitis following contact with latex were studied. The control group consisted of 30 subjects without any symptoms of conjunctivitis, negative skin prick test and sIgE <0.35 kU/l for latex. Questionnaires on signs and symptoms, skin prick tests with latex, sIgE and CAC with latex extract were administered. The study was performed at the Department of Allergology of the Medical University of Gdansk in Poland. Results: CAC with latex was positive in 46 patients (92%) and in none of the control group. CAC was the most sensitive diagnostic method (92% sensitivity and 100% specificity). The sensitivity of other methods (skin prick test and sIgE) was lower: 84 and 88%, respectively. Provocation did not induce any serious adverse events. Conclusion: Our study demonstrated the high sensitivity and safety of CAC with the extract of latex allergens in the diagnosis of patients with latex allergy. This method may be considered a diagnostic option in cases with uncertain diagnosis.

show abstract

Section: Discussionmentioning

confidence: 99%

Clinical Value of Conjunctival Allergen Challenge in Diagnosing Allergic Conjunctivitis Related to Latex

Chełmińska

Niedoszytko

Jassem³

2010

Int Arch Allergy Immunol

View full text Add to dashboard Cite

show abstract

“…Injected, red conjunctiva and either congested conjunctiva and/or swollen caruncula lacrimalis were regarded as a positive result (35,38). Thirty fil (one drop) of the concentration 50,000 BU/ml was instilled into the inferior recess without touching it.…”

Section: Patients and Study Designmentioning

confidence: 99%

Clinical History, Skin Prick Test and RAST in the Diagnosis of Birch and Timothy Pollinosis

Petersson

Dreborg²,

Ingestad

1986

Allergy

View full text Add to dashboard Cite

The diagnostic efficacy of clinical history (CH), skin prick test (SPT) and RAST was estimated in relation to nasal and conjunctival provocation tests (NPT, CPT) in 69 patients with seasonal rhinoconjunctivitis. The extracts used were freeze-dried, and biologically standardized birch and timothy allergen preparations matched to the extracts on Phadebas RAST discs. Based on single determinations the sensitivity, specificity and predictive values were calculated. There were highly significant (P less than 0.001) correlations between all parameters: NPT, CPT, CH, SPT and RAST. For birch the combination of SPT and RAST made the PTs superfluous as both sensitivity and specificity then reached 100%. With timothy the sensitivity was 97% and with the addition of CH 100%. However, the specificity was only 79% through combining CH, SPT and RAST. The present study using the same standardized allergen preparation in all tests showed a good correlation between indirect test results and provocation tests.

show abstract

“…The CPTs are among the earliest provocation tests used in humans since their use in 1911 by Noon to demonstrate the efficacy of hyposensitization with a pollen extract [10]. Later, CPTs have been extensively used for diagnostic purposes but the quality of the allergen extracts and the difficulties in quantifying the amount of allergens used have cast doubts on the safety and reproducibility of this method [11,12]. However, when newer, standardized extracts were made available, Moller et al [8] showed that the CPT was the simplest challenge test to perform in humans since very few materials were required, the test was safe and the results reproducible.…”

Section: Discussionmentioning

confidence: 99%

Effect of cetirizine in a conjunctival provocation test with allergens

Schoeneich¹,

Pécoud²

1990

Clin Experimental Allergy

View full text Add to dashboard Cite

Cetirizine is a new selective H1-antagonist. In a double-blind and placebo-controlled study, 11 subjects underwent a conjunctival provocation test (CPT) with a grass pollen extract to determine the effect of cetirizine on allergen-induced itching and redness of the eye. Results of CPTs were reproducible, as no difference was observed between the CPTs performed without any pre-treatment and the CPTs after placebo. Compared to placebo, cetirizine administered orally (10 mg twice a day for 4 days) and in double-blind fashion increased the conjunctival reaction threshold (P less than 0.004) by inhibiting both redness and itching of the eye. Cetirizine should protect patients against allergic conjunctivitis.

show abstract

XI. A dry pollen ophthalmic test in pollen asthma and hay fever patients negative to cutaneous tests

Cited by 39 publications

References 10 publications

Clinical Value of Conjunctival Allergen Challenge in Diagnosing Allergic Conjunctivitis Related to Latex

Clinical Value of Conjunctival Allergen Challenge in Diagnosing Allergic Conjunctivitis Related to Latex

Clinical History, Skin Prick Test and RAST in the Diagnosis of Birch and Timothy Pollinosis

Effect of cetirizine in a conjunctival provocation test with allergens

Contact Info

Product

Resources

About