Xerostomia: Few dry facts about dry mouth

Rao, Prasanna Kumar; Chatra, Laxmikanth; Shenai, Prashanth; Koul, Veena; Prabhu, Rachana V; Kushraj, Tashika; Shetty, Prathima; Hameed, Shaul

doi:10.4103/2321-4848.144335

Cited by 5 publications

(5 citation statements)

References 1 publication

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“…The inclusion criteria was being aged between 18-65 years. The exclusion criteria were as follows: (1) salivary flow rate less than 0.1 mL/min (diagnostic criteria for xerostomia); (2) disease in the teeth, mouth, pharynx, larynx, esophagus, or respiratory system; (3) consumption of functional foods or use of oral care products that influence the oral environment during the test period; (4) mouth breather; (5) burden on the mouth, pharynx, larynx, esophagus, and respiratory system; (6) smoker; (7) heavy drinker; (8) irregular wake-up time and bedtime; (9) serious disease in the liver, kidney, heart, lung, gastrointestinal tract, blood, endocrine system, and metabolic system; chronic disease; or serious medical history of these; (10) serious food allergy, such as milk or drug allergies, or a serious medical history of these conditions; (11) pregnant, under lactation, or expected to be pregnant during the course of the study; and (12) determined as ineligible for participation in this study, judging from the principal researcher/doctor's opinions on the findings of their background. The background information confirmed by the principal researcher/doctor included recent hospital records, medication status, subjective symptoms, and basic demographics such as sex, age, body weight, and height.…”

Section: Participantsmentioning

confidence: 99%

“…Loss of moisture in the mouth due to reduced salivation and/or excessive saliva evaporation can cause xerostomia [ 10 ]. Patients with xerostomia complain of oral and throat symptoms, such as dryness and speech and swallowing difficulties [ 11 , 12 , 13 ]. In a low-humidity environment, even healthy people experience such oral and throat discomfort transiently [ 14 , 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

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Effects of Lactoferrin on Oral and Throat Conditions under Low Humidity Environments: A Randomized, Double-Blind, and Placebo-Controlled Crossover Trial

Kubo,

Oda,

Tanaka

et al. 2023

Nutrients

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To evaluate the effects of a single ingestion of bovine lactoferrin (bLF) on oral and throat conditions under a low-humidity environment. A randomized, double-blind, 2-sequence, 2-treatment, and 2-period placebo-controlled crossover trial was conducted. Healthy adult subjects orally ingested bLF dissolved in water, or placebo water, followed by exposure to low humidity (20 °C, 20% relative humidity (RH)) for 2 h. The primary endpoint was subjective oral and throat discomfort assessed by a visual analog scale (VAS), which positively correlated with the discomfort. Secondary endpoints were unstimulated whole salivary flow rate (UWSFR) and salivary immunoglobulin A (IgA) secretion rate. Overall, 40 subjects were randomly assigned to two sequences (20 each) and 34 were analyzed. The VAS values for oral and throat discomfort in the bLF treatment were significantly lower than in the placebo treatment, whereas UWSFR and IgA secretion rates were comparable between the two treatments. Adverse drug reactions were not observed. Subjective oral and throat discomfort associated with low humidity is suppressed by a single ingestion of bLF. Our findings demonstrate the novel use of bLF in a clinical situation that leverages its unique characteristics.

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Section: Participantsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of Lactoferrin on Oral and Throat Conditions under Low Humidity Environments: A Randomized, Double-Blind, and Placebo-Controlled Crossover Trial

Kubo,

Oda,

Tanaka

et al. 2023

Nutrients

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“…2 Penurunan sekresi saliva penderita sebagai mulut kering karena terjadi penurunan fungsi lubrikasi saliva, yang selanjutnya juga akan meningkatkan risiko kejadian ulserasi. 18,19 Hal tersebut berbeda dengan yang terjadi pada perokok aktif, kebiasaan merokok cenderung menghambat terjadinya ulserasi. Hal ini disebabkan adanya proses keratinasi mukosa rongga mulut dan kenaikan IgA dalam saliva yang memberikan efek antimikroba pada perokok aktif.…”

Section: Pembahasanunclassified

Perbedaan volume, pH saliva dan kondisi rongga mulut wanita perokok dan non perokokThe differences of salivary volume, pH and oral cavity conditions of women smokers and non-smokers

2022

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Bahaya rokok dapat berdampak kepada semua orang, namun wanita perokok memiliki risiko yang lebih tinggi. Panas hasil pembakaran rokok dan kandungan kimia yang terdapat dalam rokok dapat menyebabkan penurunan aliran darah dan fungsi kelenjar saliva yang memengaruhi kondisi rongga mulut wanita perokok. Tujuan penelitian menganalisis perbedaan nilai volume saliva, pH saliva dan kondisi rongga mulut antara wanita perokok dan non perokok. Metode: Jenis penelitian deskriptif komparatif. Data yang digunakan data sekunder dengan pengambilan sampel secara consecutive sampling. Penentuan jumlah sampel menggunakan Lemeshow. Data objektif volume saliva diperoleh dengan metode spitting dan pH saliva ditentukan menggunakan pH paper test. Data kondisi rongga mulut diperoleh dari pengisian kuesioner. Responden dalam penelitian ini 26 wanita perokok dan 26 wanita non perokok. Data volume dan pH saliva dianalisis dengan uji t independen dan data kondisi rongga mulut dianalisis dengan uji z parametrik dengan nilai signifikansi p<0,05. Hasil: Terdapat perbedaan signifikan pada sampel pH saliva (p=9,60) dan adanya kondisi karies (p=0,0523), dan tidak terdapat perbedaan signifikan pada volume saliva (p=1,25), ulserasi (p=0,3989), gusi berdarah (p=0,1237) dan mulut kering (p=0,0864) antara wanita perokok dan wanita non perokok. Simpulan: Terdapat perbedaan nilai pH saliva antara wanita perokok dan wanita non perokok. Tidak terdapat perbedaan pada nilai volume saliva dan kondisi rongga mulut antara wanita perokok dan wanita non perokok.Kata kunci: kondisi rongga mulut; pH saliva; volume saliva; wanita perokok The differences of salivary volume, pH and oral cavity conditions of women smokers and non-smokers

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“…The maintaining of normal salivary function is important for a healthy oral environment. The hypofunction of the salivary gland can induce several clinical discomforts, such as swallowing problems, xerostomia, and halitosis [2]. Furthermore, this functional disorder of the salivary gland worsens quality of life and increases the prevalence of various oral diseases, such as periodontitis, mucositis, and tooth decay [3].…”

Section: Introductionmentioning

confidence: 99%

Advanced Glycation End Products Increase Salivary Gland Hypofunction in d-Galactose-Induced Aging Rats and Its Prevention by Physical Exercise

Jung

Park

Kim

et al. 2021

CIMB

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A declined salivary gland function is commonly observed in elderly people. Advanced glycation end products (AGEs) are believed to contribute to the pathogenesis of aging. Although physical exercise is shown to increase various organ functions in human and experimental models, it is not known whether it has a similar effect in the salivary glands. In the present study, we evaluated the AGEs burden in the salivary gland in the aging process and the protective effect of physical exercise on age-related salivary hypofunction. To accelerate the aging process, rats were peritoneally injected with D-galactose for 6 weeks. Young control rats and d-galactose-induced aging rats in the old group were not exercised. The rats in the physical exercise group ran on a treadmill (12 m/min, 60 min/day, 3 days/week for 6 weeks). The results showed that the salivary flow rate and total protein levels in the saliva of the d-galactose-induced aging rats were reduced compared to those of the young control rats. Circulating AGEs in serum and secreted AGEs in saliva increased with d-galactose-induced aging. AGEs also accumulated in the salivary glands of these aging rats. The salivary gland of aging rats showed increased reactive oxygen species (ROS) generation, loss of acinar cells, and apoptosis compared to young control mice. However, physical exercise suppressed all of these age-related salivary changes. Overall, physical exercise could provide a beneficial option for age-related salivary hypofunction.

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Xerostomia: Few dry facts about dry mouth

Cited by 5 publications

References 1 publication

Effects of Lactoferrin on Oral and Throat Conditions under Low Humidity Environments: A Randomized, Double-Blind, and Placebo-Controlled Crossover Trial

Effects of Lactoferrin on Oral and Throat Conditions under Low Humidity Environments: A Randomized, Double-Blind, and Placebo-Controlled Crossover Trial

<p><strong>Perbedaan volume, pH saliva dan kondisi rongga mulut wanita perokok dan non perokok</p><strong><em>The differences of salivary volume, pH and oral cavity conditions of women smokers and non-smokers</em><strong>

Advanced Glycation End Products Increase Salivary Gland Hypofunction in d-Galactose-Induced Aging Rats and Its Prevention by Physical Exercise

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