Xerostomia and chronic oral complications among patients treated with haematopoietic stem cell transplantation

Brand, H.S.; Bots, Casper P.; Raber-Durlacher, Judith E.

doi:10.1038/sj.bdj.2009.977

Cited by 41 publications

(45 citation statements)

References 24 publications

(18 reference statements)

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“…Similar to the current study, a study by Brand et al (2009) on a small number of HSCT recipients (n = 48) also observed no associations between the diagnosis and subjective feeling of dry mouth (xerostomia). Although, the primary diagnoses were not associated with the saliva flow rates, for the broader diagnose groups an association was found.…”

Section: Discussionsupporting

confidence: 86%

Longitudinal Assessment of Hematopoietic Stem Cell Transplantation and Hyposalivation

et al. 2011

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Hyposalivation is a common adverse effect of anti-neoplastic therapy of head and neck cancer, causing impaired quality of life and predisposition to oral infections. However, data on the effects of hematopoietic stem cell transplantation (HSCT) on salivary secretion are scarce. The present study determined stimulated whole-saliva flow rates in HSCT recipients in comparison with a healthy control group. Stimulated whole-saliva flow rates of 228 allogeneic HSCT recipients (134 males, 94 females; mean age, 43 yrs) were examined pre-HSCT and 6, 12, and 24 months post-HSCT. Healthy individuals (n = 144; 69 males, 75 females; mean age, 46 yrs) served as the control group. Stimulated saliva flow rates (mL/min) were measured and analyzed statistically, stratifying for hematological diagnoses and conditioning therapy. Hyposalivation (≤ 0.7 mL/min) was found in 40% (p < 0.00001), 53% (p < 0.00001), 31% (p < 0.01), and 26% (n.s.) of the recipients pre-HSCT, and 6, 12, and 24 months post-HSCT, respectively, whereas 16% of the control individuals had hyposalivation. Severe hyposalivation (≤ 0.3 mL/min) was found in 11%, 18%, 4%, and 4% of the recipients pre-HSCT, and 6, 12, and 24 months post-HSCT, respectively. Additionally, conditioning regimen and sex had an impact on saliva flow. In conclusion, hyposalivation was observed to be a common but generally reversible complication among HSCT recipients.

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Section: Discussionsupporting

confidence: 86%

Longitudinal Assessment of Hematopoietic Stem Cell Transplantation and Hyposalivation

et al. 2011

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“…In this study, the mean scores for total XI‐PL are higher than studies conducted by others employing XI in diverse disease states (Thomson et al , 1999, 2006; Thomson and Williams, 2000; Agha‐Hosseini et al , 2009; Brand et al , 2009; Garcia et al , 2009; van der Putten et al , 2011). These results are probably related to severity of the salivary gland impairment presented by the patients in this study.…”

Section: Discussioncontrasting

confidence: 73%

Translation, validation, and construct reliability of a Portuguese version of the Xerostomia Inventory

et al. 2011

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“…Today, TBI is mainly achieved with conventional radiotherapy (RT) using anteroposterior fields and a long source–skin distance (SSD). Limits of this 50‐year old technique have been previously described: dose heterogeneity, long treatment time, low ability to protect organs at risk (OAR) and, thus, acute and late toxicity 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 . Moreover, treatment planning systems (TPS) are not useable with this technique.…”

Section: Introductionmentioning

confidence: 99%

Virtual bolus for total body irradiation treated with helical tomotherapy

Moliner

Izar²,

Ferrand

et al. 2015

J Applied Clin Med Phys

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Intensity‐modulated radiation therapy (IMRT) for total body irradiation (TBI) is practiced in several centers using the TomoTherapy System. In this context the planning target volume (PTV) is the entire body including the skin. A safety margin in the air surrounding the body should be added to take into account setup errors. But using inverse planning, over‐fluence peak could be generated in the skin region to insure dose homogeneity. This work proposes to study the performance of the use of a virtual bolus (VB). A VB is a material placed on the skin surface during planning, but absent for the real treatment. The optimal VB that compensates large setup errors without introducing a high‐dose increase or hot spots for small setup errors was determined. For two cylindrical phantoms, 20 VBs with different densities, thicknesses or designs were tested. Dose coverage of the PTV (V95%) in the presence of simulated setup errors was computed to assess the VB performance. A measure of the dose increase in the phantom center due to the absence of the VB during treatment was also achieved. Finally, the fluence peak at the phantom edge was measured in complete buildup conditions using a large phantom and a detector matrix. Using these VBs, simulated setup errors were compensated to a minimum value of 2.6 and 2.1 cm for small and large phantom, respectively (and only 1.2 and 1.7 cm with no VB). An optimal double‐layer VB was found with a density of 0.4 kg.normalm−3 and a total thickness of 8 mm; an inner layer of 5 mm was declared as the target for the treatment planning system and an additional layer of 3 mm was added to avoid the over‐fluence peak. Using this VB, setup errors were compensated up to 2.9 cm. The dose increase was measured to be only +1.5% at the phantom center and over‐fluence peak was strongly decreased.PACS numbers: 87.53 Bn, 87.55 D‐, 87.55 de, 87.55 dk

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Xerostomia and chronic oral complications among patients treated with haematopoietic stem cell transplantation

Cited by 41 publications

References 24 publications

Longitudinal Assessment of Hematopoietic Stem Cell Transplantation and Hyposalivation

Longitudinal Assessment of Hematopoietic Stem Cell Transplantation and Hyposalivation

Translation, validation, and construct reliability of a Portuguese version of the Xerostomia Inventory

Virtual bolus for total body irradiation treated with helical tomotherapy

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