Xenogenic demineralized bone matrix and fresh autogenous cortical bone effects on experimental bone healing: radiological, histopathological and biomechanical evaluation

Bigham, A. S.; Dehghani, S.; Shafiei, Zahra; Nezhad, Simin Torabi

doi:10.1007/s10195-008-0006-6

Cited by 55 publications

(46 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This happens because of the osteoinductivity of DBM (WANG et al, 2000). The osteoinductivity of DBM is related to the release of BMP in the implanted sites (BIGHAM et al, 2008). DBM supports new bone formation through osteoconductive mechanisms (MOSHIRI et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Characterization of turtle demineralized bone matrix (DBM) and turtle bone in rat radial bone defects; radiological, histopathological, biomechanical and scanning electron microscopic evaluation

2017

View full text Add to dashboard Cite

Bone grafts are used to treat various disorders, including delayed union and nonunion of fractures, congenital pseudoarthrosis, and osseous defects from trauma, infection, and tumors. The disadvantages of allografts, such as disease transmission, have led to the exploration of xenografts as an alternative grafting material. We used turtle DBM and turtle bone grafts in this study. A critical size defect of 2.5 times diameter elongation was created in the radial diaphysis of 16 rats in this study. The rats were divided into 4 groups: defect as control˗, autograft as control+, turtle bone and turtle DBM. The results of radiological, histopathological, biomechanical and scanning electron microscopic evaluation of groups were compared. The biomechanical and radiological evaluation shows that there was no significant difference between groups; but histopathological evaluation shows significant differences between groups in union and cancellous bone. The turtle DBM group had the same result as control+ and was superior to the other groups.

show abstract

Section: Discussionmentioning

confidence: 99%

Characterization of turtle demineralized bone matrix (DBM) and turtle bone in rat radial bone defects; radiological, histopathological, biomechanical and scanning electron microscopic evaluation

2017

View full text Add to dashboard Cite

show abstract

“…Xenografts are originated from one species and transplanted to another species, for example, from fish to bovine. The xenografts are usually transplanted as a calcified matrix unit (Shegarfi and Reikeras 2009); however, it is also possible to transplant materials such as demineralized bone matrix (DBM) that have been obtained from the demineralized xenograft bones (Bigham et al 2008). DBM has successfully been practiced in various studies to fill defects, reconstruct cranio-maxillofacial fractures, bridge large bone and high risk defects, and induce bone formation (Bigham et al 2009).…”

Section: Introductionmentioning

confidence: 99%

Fish bone versus fish demineralized bone matrix (vertebra) effects on healing of experimental radial defect in rat model

Oryan

Bigham-Sadegh²,

Monazzah

2016

Comp Clin Pathol

View full text Add to dashboard Cite

Surgeons conducting bone grafting procedures have been in search of a bone graft substitute to avoid autogenous bone harvesting because of its associated complications. In the present study, the authors used fish bone and fish DBM in healing of a radial bone defect in a rat model. The 16 female Sprague-Dawley rats used in the present study were divided into the following four groups: autograft (positive control), untreated defect (negative control), and fish DBM, and fish bone graft as the experimental groups. Radiographs were taken in the 1st, 35th, and 56th post-operative days. Histopathological and biomechanical evaluations were performed in 56th post-operative day. The radiological, histopathological, and biomechanical evaluations revealed a superior rate of bone formation in the fish bone graft and autograft groups compared to those of the control. This study showed that the fish bone graft is effective in healing of the radial bone defect in rat.

show abstract

“…There are many cases in which bone grafts are needed in large quantity such as for reconstruction of large bone defects caused by trauma, tumors, infections, and congenital defects, and also in cases where the regeneration is compromised (osteoporosis, necrosis and atrophic non-unions) [4,5]. All these facts emphasis that, large bone defects are still a challenge for maxillofacial surgeons.…”

Section: Introductionmentioning

confidence: 99%

“…3 Ceramic with combination of calcium aluminate added with melatonin and platelet rich plasma Adhesion, viability, and proliferation of osteoblasts [178]. 4 Bioglass-calcium phosphate composite…”

Section: Ceramicmentioning

confidence: 99%

Bone Graft Substitutes for Bone Defect Regeneration. A Collective Review

Kheirallah¹,

Almeshaly²

2016

IJDOS

View full text Add to dashboard Cite

Objective: The purpose of this review article is to illustrate the current state of development of bone graft substitutes that could be used for bone defect regeneration, as well as to analyze their efficacy for clinical use. Methods: An electronic search of the PubMed, was performed for articles written in English. The focused question was "ideal graft substitute material to choose in clinical practice"?. The searches were limited to articles including: bone graft, bone defect scaffold, bone substitutes, and bone regeneration. An attempt was made to identify clinical studies. During the data collection, the data were extracted from the studies including scaffold material, properties and advantages of bone substitutes, as well as clinical results if the study has been provided clinically. Results: In spite of several acceptable scaffold options available for bone regeneration, these options still need to bridge the gap between research and clinical practice. There is little information available about the cellular basis for bone regeneration in humans. Several problems limit the broad usage of such options, including lack of randomized controlled human studies, and dubious long term results. Conclusion:The studies should be nurtured and monitored by a combination of clinical experience. Future trends may focus on the effective combinations of osteoinductive materials, osteoinductive growth factors and cell-based tissue regeneration tactics using composite carriers. There is no single ideal graft material to choose in clinical practice, therefore researches are ongoing in all relevant fields, to establish modern bone regeneration protocols that may lead to the innovation of ideal graft substitutes.

show abstract

Xenogenic demineralized bone matrix and fresh autogenous cortical bone effects on experimental bone healing: radiological, histopathological and biomechanical evaluation

Cited by 55 publications

References 42 publications

Characterization of turtle demineralized bone matrix (DBM) and turtle bone in rat radial bone defects; radiological, histopathological, biomechanical and scanning electron microscopic evaluation

Characterization of turtle demineralized bone matrix (DBM) and turtle bone in rat radial bone defects; radiological, histopathological, biomechanical and scanning electron microscopic evaluation

Fish bone versus fish demineralized bone matrix (vertebra) effects on healing of experimental radial defect in rat model

Bone Graft Substitutes for Bone Defect Regeneration. A Collective Review

Contact Info

Product

Resources

About