Untitled

Abstract

Objectives: There are numerous changes in inflammatory status that occur after a kidney transplant. Pentraxin 3 is a marker of inflammation, but little information is available about pentraxin 3 levels after a kidney transplant. We evaluated the relation between pentraxin 3 and other inflammatory markers including high sensitivity C-reactive protein, interleukin 6, and tumor necrosis factor α in kidney transplant recipients. Materials and Methods: Adult patients (40 patients; aged, 18-80 y; mean age, 38 ± 10 y) who had a kidney transplant from living-related donors were studied. Patients who had comorbidities associated with chronic inflammation were excluded. Blood samples were obtained before starting immunosuppressive treatment and 2 months after kidney transplant for measurement of pentraxin 3, high sensitivity C-reactive protein, interleukin 6, and tumor necrosis factor α levels. Results: After transplant, mean levels of high sensitivity C-reactive protein and interleukin 6 decreased but levels of pentraxin 3 and tumor necrosis factor α did not change. There were significant correlations between interleukin 6 and high sensitivity C-reactive protein before transplant (r = 0.71; P ≤ .0001) and after transplant (r = 0.45; P ≤ .003). There was no correlation between tumor necrosis factor α and high sensitivity C-reactive protein before transplant, but there was a significant correlation between tumor necrosis factor α and high sensitivity C-reactive protein after transplant (r = 0.36; P ≤ .03). There was no correlation between interleukin 6 and pentraxin 3, tumor necrosis factor α and pentraxin 3, or high sensitivity C-reactive protein and pentraxin 3 before or after transplant. Conclusions: After a kidney transplant, pentraxin 3 may not be useful in determining inflammatory status, and high sensitivity C-reactive protein may be better than pentraxin 3 as a marker of inflammation.

Association between serum levels of pentraxin-3, mannose binding lectin and high sensitivity C-reactive protein with renal transplantation

“…According to our study, changes in PTX-3 after transplantation were significant. Contrary to our findings, Gursu et al suggested that PTX-3 may not help diagnose inflammatory conditions after kidney transplantation and CRP may be better than PTX-3 as a marker of inflammation (28). In their study, after transplantation, the mean CRP and IL-6 levels decreased but the PTX-3 and TNF-α levels did not change and a significant correlation was found between IL-6 and CRP before and after transplantation.…”

“…They found no significant association between TNF-α and hs-CRP hypersensitivity before transplantation, but a significant correlation was reported after transplantation. There was no significant association between IL-6 and PTX-3, TNF-α and PTX-3, or hs-CRP and PTX-3 before or after transplantation (28). The findings of the study by Gursu and colleagues were contrary to us and the reason for this difference is unclear.…”

Evaluation of Serum Interleukin-6 Levels in the Renal Transplant Recipients: A Systematic Review and Meta-Analysis of Case-Control Studies

“…Increased IL-6 leads to chronic inflammatory conditions such as the synthesis of acute phase proteins like CRP, hypercoagulability and accelerated atherosclerosis. [7], [28], [29], [30], [31] that can cause to the loss of renal function [7]. Also, some mechanisms including volume overload and oxidative stress can cause the usual increase in inflammatory symptoms (including IL-6) [32].…”