Evaluation of Serum Interleukin-6 Levels in the Renal Transplant Recipients: A Systematic Review and Meta-Analysis of Case-Control Studies

Omrani, Hamidreza; Jasemi, Seyed Vahid; Sadeghi, Masoud; Golmohamadi, Sima

doi:10.3889/oamjms.2019.027

Cited by 7 publications

(4 citation statements)

References 32 publications

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“…CRP, D‐dimer, and ferritin levels were all above normal ranges in COVID‐19 patients (Table 2). Analysis of serum IL‐6 levels (a proinflammatory mediator) in the COVID‐19 positive subjects revealed median values of 237.5 pg/mL (95% confidence interval [CI]: 55.3‐422.7) (Table 2) that are remarkably higher than those reported by others in stable, noninfected, kidney transplant recipients (<5 pg/mL) 8 …”

Section: Resultsmentioning

confidence: 83%

Evidence of potent humoral immune activity in COVID-19-infected kidney transplant recipients

Hartzell

Bin

Benedetti

et al. 2020

American Journal of Transplantation

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Whether kidney transplant recipients are capable of mounting an effective anti‐severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) adaptive immune response despite chronic immunosuppression is unknown and has important implications for therapy. Herein, we analyzed peripheral blood cell surface and intracellular cytokine phenotyping by flow cytometry along with serum antibody testing in 18 kidney transplant recipients with active coronavirus disease 2019 (COVID‐19) infection and 36 matched, transplanted controls without COVID‐19. We observed significantly fewer total lymphocytes and fewer circulating memory CD4+ and CD8+ T cells in the COVID‐19 subjects. We also showed fewer anergic and senescent CD8+ T cells in COVID‐19 individuals, but no differences in exhausted CD8+ T cells, nor in any of these CD4+ T cell subsets between groups. We also observed greater frequencies of activated B cells in the COVID‐19 patients. Sixteen of 18 COVID‐19 subjects tested for anti‐SARS‐CoV‐2 serum antibodies showed positive immunoglobulin M or immunoglobulin G titers. Additional analyses showed no significant correlation among immune phenotypes and degrees of COVID‐19 disease severity. Our findings indicate that immunosuppressed kidney transplant recipients admitted to the hospital with acute COVID‐19 infection can mount SARS‐CoV‐2‐reactive adaptive immune responses. The findings raise the possibility that empiric reductions in immunosuppressive therapy for all kidney transplant recipients with active COVID‐19 may not be required.

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Section: Resultsmentioning

confidence: 83%

Evidence of potent humoral immune activity in COVID-19-infected kidney transplant recipients

Hartzell

Bin

Benedetti

et al. 2020

American Journal of Transplantation

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“…We began by investigating whether the IL-6 levels from transplanted patients would differ from healthy people. The meta-analysis reported an average of 2.55 pg/mL increased serum levels of this inflammatory cytokine when compared to a healthy systemic state, and previous research confirms this result [46,[49][50][51]66,67]. This result was of low-quality of evidence due to the moderated inconsistency and studies included few patients with wide confidence interval around the estimate of the effect.…”

Section: Summary Of Main Findingsmentioning

confidence: 75%

Periodontitis Impact in Interleukin-6 Serum Levels in Solid Organ Transplanted Patients: A Systematic Review and Meta-Analysis

et al. 2020

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This systematic review aimed to investigate the influence of periodontitis on post-transplant IL-6 serum levels of solid organ transplanted patients as compared to healthy subjects. Four databases (PubMed, Scholar, EMBASE, and CENTRAL) were searched up to February 2020 (PROSPERO CRD42018107817). Case-control and cohort studies on the association of IL-6 serum levels with a periodontal status of patients after solid organ transplantation were included. The risk of bias of observational studies was assessed through the Newcastle-Ottawa Scale (NOS). Random effects meta-analyses were thoroughly conducted. GRADE assessment provided quality evidence. Four case-control studies fulfilled the inclusion criteria (274 transplant recipients and 146 healthy controls), all of low risk of bias. Meta-analyses revealed significantly higher IL-6 levels in transplanted patients than healthy individuals with low-quality evidence (Mean Difference (MD): 2.55 (95% confidence interval (CI): 2.07, 3.03)). Transplanted patients with periodontitis have higher serum IL-6 levels than transplanted patients without periodontitis with moderate quality evidence (MD: 2.20 (95% CI: 1.00, 3.39)). We found low-quality evidence of higher IL-6 levels than healthy patients in patients with heart and kidney transplant. In these transplanted patients, there was moderate quality evidence that periodontitis is associated with higher IL-6 serum levels. Future research should consider the impact of such a difference in organ failure and systemic complications.

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“…Chronic inflammation and cytokine storm are uncontrolled forms of inflammation [ 68 ], and IL-6 is produced by senescent cells and is involved in aging-induced inflammation and age-related pathologies and cancer [ 69 ]. Several recent meta-analyses have reported higher levels of serum/plasma IL-6 in patients with various diseases, including obstructive sleep apnea syndrome [ 70 ], kidney disease [ 71 ], hepatocellular carcinoma [ 72 ], COVID-19 [ 73 , 74 ], and colorectal cancer [ 75 ], compared to controls.…”

Section: Discussionmentioning

confidence: 99%

A systematic review and meta-analysis to evaluate blood levels of interleukin-6 in lung cancer patients

Jasemi,

Zia,

Mirbahari

et al. 2023

kitp

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Introduction The exact mechanism responsible for inflammation in malignancy is not completely understood, but it is possible that interleukin-6 (IL-6) plays a major role in triggering and maintaining an inflammatory response. Aim To conduct a systematic review and meta-analysis of the levels of IL-6 in the serum/plasma of lung cancer (LC) patients. Material and methods The researchers searched four databases up to September 11, 2022, to find studies that reported on IL-6 levels in LC patients compared to healthy controls (HCs). They calculated effect sizes using standardized mean difference (SMD) with a 95% confidence interval (CI). To evaluate the quality of each study, they used the Newcastle-Ottawa Scale (NOS). They performed subgroup analysis, sensitivity analysis, meta-regression analysis, heterogeneity analyses, trial sequential analysis, and publication bias with the trim-and-fill method. Results The meta-analysis included 28 studies, and the results showed that the pooled SMD was 1.71 (95% CI: 1.22, 2.19; p < 0.00001; I 2 = 98%), indicating that LC patients had significantly higher levels of IL-6 in their serum/plasma than HCs. Conclusions The study found that the publication year and quality score of the studies were positively associated with the level of IL-6, while the sample size was inversely related. The research suggests that measuring IL-6 levels in the blood could be useful for detecting and monitoring LC as it appears to be a reliable biomarker.

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Evaluation of Serum Interleukin-6 Levels in the Renal Transplant Recipients: A Systematic Review and Meta-Analysis of Case-Control Studies

Cited by 7 publications

References 32 publications

Evidence of potent humoral immune activity in COVID-19-infected kidney transplant recipients

Evidence of potent humoral immune activity in COVID-19-infected kidney transplant recipients

Periodontitis Impact in Interleukin-6 Serum Levels in Solid Organ Transplanted Patients: A Systematic Review and Meta-Analysis

A systematic review and meta-analysis to evaluate blood levels of interleukin-6 in lung cancer patients

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