Xanthone Derivatives: New Insights in Biological Activities

Pinto, Madalena; Sousa, Emı́lia; Nascimento, María Säo José

doi:10.2174/092986705774370691

Cited by 435 publications

(237 citation statements)

References 256 publications

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“…Benzoxanthens are known, due to their numerous occurence in nature and extensive range of pharmacological and therapeutic properties, including antiviral, 28 antibacterial, 29 anti-inflammatory, 30 and other bioorganic characteristics. 31 In addition, these compounds are applied widely in laser technologies, 32 dyes, 33 and as pHsensitive fluorescent materials for visualization of biomolecules.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of Fe3O4@SiO2 NPs as an Effective Catalyst for the Synthesis of Tetrahydrobenzo[a]xanthen-11-ones

Ghasemzadeh¹

2015

ACSi

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In this research, the significant application of Fe 3 O 4 @SiO 2 core-shell nanoparticles as efficient, green, robust, cost-effective and recoverable nanocatalyst for the multi-component reaction of aldehydes, 2-naphthol and dimedone has been developed in aqueous ethanol media under reflux conditions. In the presented procedure we had avoided to use of hazardous reagents and solvents and therefore this method can be considered as a green alternative pathway in comparison with the previous method. Simple procedure, environmentally benign, excellent yields, short reaction times, simple purification and facile catalyst separation are advantages of this protocol. Characterization and structural elucidation of the prepared products have been done on the basis of chemical, analytical and spectral analysis. In addition, the heterogeneous nanoparticles were fully characterized by FT-IR, XRD, EDX, VSM and SEM analysis.

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Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of Fe3O4@SiO2 NPs as an Effective Catalyst for the Synthesis of Tetrahydrobenzo[a]xanthen-11-ones

Ghasemzadeh¹

2015

ACSi

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“…The major bioactive secondary metabolites of G. mangostana are xanthone derivatives and they are present mostly in the pericarp of the fruit [3]. Xanthones is a class of polyphenolic compounds with a skeleton of a xanthene-9-one [4]. The most studied xanthones are a-, b-and c-mangostins, garcinone E, mangostenones and gartanin.…”

Section: Introductionmentioning

confidence: 99%

Inhibition of cell proliferation, migration and invasion of B16-F10 melanoma cells by α-mangostin

Beninati¹,

Oliverio²,

Cordella³

et al. 2014

Biochemical and Biophysical Research Communications

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a b s t r a c tIn this study, we have evaluated the potential antineoplastic effects of a-mangostin (a-M), the most representative xanthone in Garcinia mangostana pericarp, on melanoma cell lines. This xanthone markedly inhibits the proliferation of high-metastatic B16-F10 melanoma cells. Furthermore, by deeply analyzing which steps in the metastatic process are influenced by xanthone it was observed that a-M strongly interferes with homotypic aggregation, adhesion, plasticity and invasion ability of B16-F10 cells, probably by the observed reduction of metalloproteinase-9 activity. The antiproliferative and antimetastatic properties of a-M have been established in human SK-MEL-28 and A375 melanoma cells. In order to identify pathways potentially involved in the antineoplastic properties of a-M, a comparative mass spectrometry proteomic approach was employed. These findings may improve our understanding of the molecular mechanisms underlying the anti-cancer effects of a-M on melanoma.

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“…They feature a broad-spectrum bioactivities such as anti-inflammatory, sedative, anti-tubercular, anti-protozoal, anti-bacterial and anti-fungal properties [67][68][69][70]. New strategies for the synthesis of pyrene derivatives have been developed in recent years [71,72].…”

Section: Pyransmentioning

confidence: 99%

Microwave-Assisted Synthesis of Bioactive Six-Membered Heterocycles and Their Fused Analogues

et al. 2016

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This review describes the formation of six-membered heterocyclic compounds and their fused analogues under microwave activation using modern organic transformations including cyclocondensation, cycloaddition, multicomponents and other modular reactions. The review is divided according to the main heterocycle types in order of increasing complexity, starting with heterocyclic systems containing one, two and three heteroatoms and their fused analogues. Recent microwave applications are reviewed, with special focus on the chemistry of bioactive compounds. Selected examples from the 2006 to 2015 literature are discussed.

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Xanthone Derivatives: New Insights in Biological Activities

Cited by 435 publications

References 256 publications

Synthesis and Characterization of Fe3O4@SiO2 NPs as an Effective Catalyst for the Synthesis of Tetrahydrobenzo[a]xanthen-11-ones

Synthesis and Characterization of Fe3O4@SiO2 NPs as an Effective Catalyst for the Synthesis of Tetrahydrobenzo[a]xanthen-11-ones

Inhibition of cell proliferation, migration and invasion of B16-F10 melanoma cells by α-mangostin

Microwave-Assisted Synthesis of Bioactive Six-Membered Heterocycles and Their Fused Analogues

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