Xanthomonas maltophilia Bacteremia in Immunocompromised Hematological Patients

Victor, Maud; Arpi, Magnus; Bruun, Brita; Jønsson, Viggo; Hansen, Mogens

doi:10.3109/00365549409011780

Cited by 87 publications

(65 citation statements)

References 24 publications

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“…The presence of an indwelling CVC has been previously reported for 78% -86% of patients [23] [24] [35] [36]. This range is lower than the proportion in our figure which was 93.5%.…”

Section: Discussioncontrasting

confidence: 78%

Stenotrophomonas maltophilia Bacteraemia: Analysis of 33 Episodes Occurred in the ICU at the University Hospital in Sousse, Tunisia

Jaidane¹,

Chaouech²,

Naija³

et al. 2014

OALib

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Background: Stenotrophomonas maltophilia is a multidrug-resistant, Gram negative bacillus that has emerged as an opportunistic pathogen associated with high morbidity and mortality rates. Aim: The aim of this study is to describe the characteristics of patients with bloodstream infections due to S. maltophilia. Methods: A descriptive retrospective study was performed at the ICUs over seven-year period in a teaching hospital. Cases of SMB were identified through a review of clinical microbiology laboratory and patient's records were retrieved for analysis. Findings: There were 22 deaths (71%) 15 ± 12 days after the bactaeremia. In our study, more than half of patients (17/31) was exposed to broad-spectrum antibiotic specifically imipinem (IMP) before their positive culture. Antibiotic susceptibility testing revealed that isolates were most sensitive to ciprofloxacin (84%) and to trimethoprim-sulfamethoxazole (71%). A probable portal of entry was identified in 27.3% of cases and 57% were catheter-related. Conclusion: Our results were similar to those described by other authors reported in the literature in the last 20 years. Prevention of S. maltophilia acquisition and infection depends on higher emphasis on control of antimicrobial consumption and consideration of environmental reservoirs.

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“…The presence of an indwelling CVC has been previously reported for 78% -86% of patients [23] [24] [35] [36]. This range is lower than the proportion in our figure which was 93.5%.…”

Section: Discussioncontrasting

confidence: 78%

Stenotrophomonas maltophilia Bacteraemia: Analysis of 33 Episodes Occurred in the ICU at the University Hospital in Sousse, Tunisia

Jaidane¹,

Chaouech²,

Naija³

et al. 2014

OALib

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“…Recognized risk factors for S. maltophilia bacteremia in oncology patients have included severe and prolonged neutropenia, intravascular devices, prolonged hospital stay, aggressive chemotherapy treatment, and increased antibiotic pressure. 2,[6][7][8]23,24 Severe mucositis was recently identified as a significant risk factor for S. maltophilia bacteremia in the investigation of an outbreak among patients receiving bone marrow transplants. 8 Our study confirmed the association of severe mucositis with S. maltophilia bacteremia in oncology patients.…”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3][4] Although it is usually considered a colonizer and is rarely responsible for community-acquired infections, 5 its role as a pathogen has been increasingly recognized among immunocompromised patients, especially patients with malignancies. 2,[6][7][8] S. maltophilia accounted for 0.6% to 0.9% of all bloodstream infections reported from the United States, Canada, and Latin America from 1997 through 1999. 9,10 Septicemia due to this organism occurs rarely, although several nosocomial outbreaks have been reported.…”

Section: Stenotrophomonas Maltophilia Formerly Known Asmentioning

confidence: 99%

“…3,8,[11][12][13][14][15][16] Recognized risk factors associated with Stenotrophomonas bacteremia include antibiotic pressure, presence of a central venous catheter, prolonged hospital stay, length of intensive care unit stay, mechanical ventilation, and aggressive chemotherapy treatment for malignancies. 2,3,[6][7][8]11,13,[17][18][19][20][21] In addition, severe neutropenia (neutrophil count < 50/mm 3 ) and mucositis were shown to be significant risk factors for S. maltophilia bacteremia in a recent outbreak study of patients receiving allogeneic bone marrow transplants. 8 From June 1999 through April 2001, 13 patients on the transplantation unit acquired S. maltophilia bacteremia compared with 1 patient between July 1997 and May 1999.…”

Section: Stenotrophomonas Maltophilia Formerly Known Asmentioning

confidence: 99%

“…When compared with control-patients concurrently hospitalized on the transplantation unit, case-patients were significantly more likely to have severe mucositis (7 26). There were no differences among case-and control-patients regarding other anti-anaerobic medications (clindamycin, extended-spectrum penicillin, and imipenem).…”

Section: Univariate Analysis (Tables 2 and 3)mentioning

confidence: 99%

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Risk Factors ForStenotrophomonas MaltophiliaBacteremia In Oncology Patients: A Case–Control Study

Apisarnthanarak¹,

Mayfield

Garison

et al. 2003

Infect. Control Hosp. Epidemiol.

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Objective:To characterize risk factors for Stenotrophomonas maltophilia bloodstream infection in oncology patients.Design:A 3:1 case–control study.Setting:Stem Cell Transplant and Leukemic Center at Barnes–Jewish Hospital (St. Louis), a 1,442-bed, tertiary-care teaching hospital with a 26-bed transplantation ward.Method:From June 1999 to April 2001,13 patients with S. maltophilia bacteremia were compared with 39 control-patients who were on the transplantation unit on the same day as the case-patients' positive blood cultures. Information collected included patient demographics, medical history, history of transplantation, transplantation type, graft versus host disease, neutropenia, antibiotic use, chemotherapy, mucositis, diarrhea, the presence of central venous catheter(s), cultures, and concomitant infections.Results:Significant risk factors for S. maltophilia bacteremia included severe mucositis (7 [53.8%] of 13 vs 8 [20.5%] of 39; P = .034), diarrhea (7 [53.8%] of 13 vs 8 [20%] of 39; P = .034), and the use of metronidazole (9 [69.2%] of 13 vs 8 [20.5%] of 39; P = .002). In addition, the number of antibiotics used (median, 9 vs 5; P < .001), duration of mucositis (median, 29 vs 15 days; P = .032), and length of hospital stay (median, 34 vs 22 days; P = .017) were significantly different between case- and control-patients. Nine S. maltophilia isolates tested by pulsed-field gel electrophoresis were found to be distinctly different.Conclusion:Interventions to ameliorate the severity of mucositis, reduce antibiotic pressure, prevent diarrhea, and promote meticulous central venous catheter care may help prevent S. maltophilia bloodstream infection in oncology patients. The role of gastrointestinal tract colonization as a potential source of S. maltophilia bacteremia in oncology patients deserves further investigation.

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Central venous catheter and Stenotrophomonas maltophilia bacteremia in cancer patients

Boktour

Hanna

Ansari

et al. 2006

Cancer

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There is no instrument to measure severity of sickle cell disease (SCD) in pediatric patients that is generally accepted. The aim of this study was to develop and validate a severity index for SCD in children. We developed an index consisting of 12 items and tested its validity of the index using data from 92 children. We tested whether different scores were obtained for patients classified by severity both subjectively and objectively by a partially validated existing index. Furthermore, we tested whether the index could differentiate patients classified according to genotype or the number of α‐gene deletions and evaluated whether the score on the index was correlated with the average number and days of hospitalizations/year, age and a risk of death score. We explored the effect of three different weighting systems (Score A, B, and C) to summarize these items. All weightings demonstrated a significant difference between the scores of mild, moderate, and severely affected patients, as classified by a subjective rating or with an existing index (P < 0.01). The index clearly differentiated patients by genotype (P < 0.01) or α‐gene deletions (P < 0.01). The correlation with hospitalization was moderate. Age and the risk of death score were weakly associated with the pediatric severity index for SCD. This is the first pediatric SCD severity index that was developed and validated using modern clinimetric methodology. The validity and reliability of this index should be further evaluated in a prospective study including a larger cohort, preferably diagnosed at birth. Am. J. Hematol., 2010. © 2010 Wiley‐Liss, Inc.

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Xanthomonas maltophilia Bacteremia in Immunocompromised Hematological Patients

Cited by 87 publications

References 24 publications

Stenotrophomonas maltophilia Bacteraemia: Analysis of 33 Episodes Occurred in the ICU at the University Hospital in Sousse, Tunisia

Stenotrophomonas maltophilia Bacteraemia: Analysis of 33 Episodes Occurred in the ICU at the University Hospital in Sousse, Tunisia

Risk Factors ForStenotrophomonas MaltophiliaBacteremia In Oncology Patients: A Case–Control Study

Central venous catheter and Stenotrophomonas maltophilia bacteremia in cancer patients

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