Xanthohumol properties and strategies for extraction from hops and brewery residues: A review

Silva, Gerbson Vicente de Andrade; Arend, Giordana Demaman; Zielinski, Acácio Antônio Ferreira; Luccio, Marco Di; Ambrosi, Alan

doi:10.1016/j.foodchem.2022.134629

Cited by 19 publications

(14 citation statements)

References 70 publications

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“…The result of the reaction is the formation of high-molecular melanoidins, which act as xanthohumol carriers, thereby stabilizing its content in beer [45,46]. Ethanol hops extract can be more cost-effective than using whole hops, especially in large brewing operations, because it eliminates the difficult storage and transportation of hops, reducing labor and logistics costs associated with handling whole hops [7]. The addition of ethanol extract from hops to filtered beer offers brewers an effective way to enhance taste, aroma and bitterness while maintaining the consistency of the product, with the added value of increased content of biologically active prenylated flavonoids.…”

Section: Discussionmentioning

confidence: 99%

“…The extract contained 5.765 mg/mL xanthohumol and 1.096 mg/mL isoxanthohumol (Table 2). Prenylchalcones, which also includes xanthohumol, are substances with a polar character [27] and have a high affinity for polar solvents such as ethanol [7]. Therefore, there is a relatively high concentration of xanthohumol in the prepared extract.…”

Section: Analysis Of Ase Extract From Hops Of the Polaris Varietymentioning

confidence: 99%

“…In order to manifest the pharmacological effects of xanthohumol on the human body, it is recommended that nutritional supplements contain a dose corresponding to 1.35 to 2.5 mg/kg per day [7]. In addition to oral consumption via capsules, this compound can also be added to foods and 2 beverages [8].…”

Section: Introductionmentioning

confidence: 99%

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Antioxidant Activity of Special Functional Beers

Urminská,

Haring,

Drábová

2024

Preprint

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Prenylated flavonoids of Humulus lupulus L. have gained attention for their potential health benefits. In this study, Amber ALE and Russian Imperial Stout beers were prepared. In order to increase the content of prenylated flavonoids in beer, there was added ethanol extract of Polaris hops, they were dry hopping with Polaris hops or pure xanthohumol was added. In unfiltered beers, the highest total content of polyphenols (3.60 ± 0.32 g/L gallic acid) was determined on the eighth day of fermentation and maturation in Amber ALE beer without the addition of extract. The highest total antioxidant capacity was determined in Russian Imperial Stout beer with the addition of xanthohumol on the eighth day of fermentation and maturation (0.675 ± 0.008 mmol/L Trolox). This type of beer also had a high antioxidant efficiency (85.96 - 88.00%). Xanthohumol (2.05 mg/L) and isoxanthohumol (2.819 mg/L) were detectable only until the thirteenth day of fermentation and beer maturation. Therefore, the beers were filtered, and the ethanol extract of the Polaris was added to them for 24 hours. This procedure was used to prepare a functional beer of the Amber ALE type (15.210 ± 0.053 mg xanthohumol in 1 L and 0.922 ± 0.077 mg isoxanthohumol in 1 L) and a functional beer of the Russian Imperial Stout type (32.375 ± 0.032 mg xanthohumol in 1 L and 1.877 ± 0.043 mg isoxanthohumol in 1 L).

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Section: Discussionmentioning

confidence: 99%

Section: Analysis Of Ase Extract From Hops Of the Polaris Varietymentioning

confidence: 99%

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Antioxidant Activity of Special Functional Beers

Urminská,

Haring,

Drábová

2024

Preprint

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“…Xanthohumol is a natural polyphenol chalcone from flowers of the common hop ( Humulus lupulus L.) ( Vicente de Andrade Silva et al, 2022 ). Xanthohumol has a variety of pharmacological activities, including antioxidant, anti-inflammatory, and anti-tumor effects ( Jiang et al, 2018 ).…”

Section: Phytochemicals Targeting Signal Pathways and Transcription F...mentioning

confidence: 99%

Phytochemicals targeting glycolysis in colorectal cancer therapy: effects and mechanisms of action

Zhan,

Su,

et al. 2023

Front. Pharmacol.

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Colorectal cancer (CRC) is the third most common malignant tumor in the world, and it is prone to recurrence and metastasis during treatment. Aerobic glycolysis is one of the main characteristics of tumor cell metabolism in CRC. Tumor cells rely on glycolysis to rapidly consume glucose and to obtain more lactate and intermediate macromolecular products so as to maintain growth and proliferation. The regulation of the CRC glycolysis pathway is closely associated with several signal transduction pathways and transcription factors including phosphatidylinositol 3-kinases/protein kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR), adenosine 5′-monophosphate (AMP)-activated protein kinase (AMPK), hypoxia-inducible factor-1 (HIF-1), myc, and p53. Targeting the glycolytic pathway has become one of the key research aspects in CRC therapy. Many phytochemicals were shown to exert anti-CRC activity by targeting the glycolytic pathway. Here, we review the effects and mechanisms of phytochemicals on CRC glycolytic pathways, providing a new method of drug development.

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“…Xanthohumol (2) is a principal prenylated chalcone isolated from hops with its anti-inflammatory, anti-oxidative, and cancer-preventive properties ( Zhou et al, 2021 ; Neumann et al, 2022 ; Vicente de Andrade Silva et al, 2023 ).2 protect cardiomyocytes against Fe-SP- and RSL3-induced ferroptosis by decreasing the production of lipid peroxidation and ROS, chelating iron, increasing the Nrf2 and GPX4 protein, while decreasing the mRNA levels of Ptgs2 and Acsl4 , and the protein levels of ACSL4 ( Lin et al, 2022 ). The poor solubility and stability severely limit 2 utilization ( Luo et al, 2023 ).…”

Section: Pharmacological Inhibition Of Ferroptosis For Treating Cardi...mentioning

confidence: 99%

Targeting ferroptosis as a promising therapeutic strategy to treat cardiomyopathy

et al. 2023

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Cardiomyopathies are a clinically heterogeneous group of cardiac diseases characterized by heart muscle damage, resulting in myocardium disorders, diminished cardiac function, heart failure, and even sudden cardiac death. The molecular mechanisms underlying the damage to cardiomyocytes remain unclear. Emerging studies have demonstrated that ferroptosis, an iron-dependent non-apoptotic regulated form of cell death characterized by iron dyshomeostasis and lipid peroxidation, contributes to the development of ischemic cardiomyopathy, diabetic cardiomyopathy, doxorubicin-induced cardiomyopathy, and septic cardiomyopathy. Numerous compounds have exerted potential therapeutic effects on cardiomyopathies by inhibiting ferroptosis. In this review, we summarize the core mechanism by which ferroptosis leads to the development of these cardiomyopathies. We emphasize the emerging types of therapeutic compounds that can inhibit ferroptosis and delineate their beneficial effects in treating cardiomyopathies. This review suggests that inhibiting ferroptosis pharmacologically may be a potential therapeutic strategy for cardiomyopathy treatment.

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Xanthohumol properties and strategies for extraction from hops and brewery residues: A review

Cited by 19 publications

References 70 publications

Antioxidant Activity of Special Functional Beers

Antioxidant Activity of Special Functional Beers

Phytochemicals targeting glycolysis in colorectal cancer therapy: effects and mechanisms of action

Targeting ferroptosis as a promising therapeutic strategy to treat cardiomyopathy

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