Xanthogranulomatous Salpingitis and Oophoritis

Gray, Yulia; Libbey, N. Peter

doi:10.5858/2001-125-0260-xsao

Cited by 51 publications

(13 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, it is rarely seen in the female genital tract [ 6 ]. In the female genital tract, it has been reported involving the endometrium [ 6 , 10 , 11 ], fallopian tubes [ 6 , 12 , 13 ], and ovary [ 6 , 14 ], primarily presenting as endometritis and/or salpingitis, with a tubo-ovarian abscess [ 8 ]. However, xanthogranulomatous inflammation with uterine myometritis, without endometritis has rarely been reported in the literature [ 8 ].…”

Section: Discussionmentioning

confidence: 99%

Exploring the Diagnostic Challenges of Uterine Lesions in Frozen Section: A Comprehensive Study at a Tertiary Care Center

B.,

2024

Cureus

View full text Add to dashboard Cite

Introduction Uterine masses are commonly submitted for frozen section, to guide the surgeon, regarding the type and extent of the procedure during surgery. Despite the technical difficulties in processing, sectioning, and staining of frozen section samples, it remains a fairly reliable intraoperative tool. Aim This study aims to analyze the diverse spectrum of uterine masses sent for frozen sections for two years. In addition, it aims to analyze the histomorphology of the uterine masses sent for the frozen section and correlate it with that of the routine histopathological findings, thereby justifying the diagnostic value of the frozen section with this study. Furthermore, the study aims to classify the lesions into benign and malignant, quantify their frequency, and list the most common lesions seen in the uterine mass specimens sent for frozen section analysis. Methodology This retrospective descriptive study includes data from January 2021 to December 2022, retrieved from the archives of the Department of Pathology at Saveetha Medical College. This study includes a total of 76 cases, including all the uterine masses sent for frozen section analysis during the study period. Results Of the total of 76 cases received, 17 (22.4%) were malignant and 59 (77.6%) were benign. Of the malignant cases reported, the most common was endometrial carcinoma, and the least common entities encountered were carcinosarcoma and leiomyosarcoma. Of the benign cases, benign endometrial polyp was the most common endometrial lesion and leiomyoma with and without degeneration was the most common myometrial lesion encountered. Of the 50 cases of leiomyoma encountered, 16 had extensive degenerative changes. The most common degeneration seen in the fibroid was hyaline degeneration, and the least common was xanthogranulomatous degeneration. Conclusions The intraoperative frozen section analysis is a very important diagnostic tool, but we need to be aware of its limitations. The accuracy, sensitivity, and specificity rates were found to be high. Thus, frozen section diagnoses can be very valuable in the clinical management of uterine tumors. Careful gross examination, sampling from representative areas, and good communication between the pathologist and surgeon may help in avoiding its limitations.

show abstract

Section: Discussionmentioning

confidence: 99%

Exploring the Diagnostic Challenges of Uterine Lesions in Frozen Section: A Comprehensive Study at a Tertiary Care Center

B.,

2024

Cureus

View full text Add to dashboard Cite

show abstract

“…The etiology of this disease is not clear yet, but the infection theory (pelvic inflammatory disease) is one of the most accepted theories since, in many cases, the presence of certain pathogenic microorganisms such as Escherichia coli , Bacteroides fragilis , Proteus , and Salmonella has been demonstrated [ 9 , 10 ]. Nonetheless, some cases have been reported as without being related to infectious processes [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

Xanthogranulomatous Endometritis: A Report of Two Cases

Silva-Rengifo¹,

Asencio²,

Salirrosas³

2023

Cureus

View full text Add to dashboard Cite

Xanthogranulomatous endometritis (XGE) or histiocytic endometritis is a chronic inflammatory pathology of rare presentation, characterized by an exaggerated inflammatory infiltrate that can mimic an endometrial carcinoma. We report two cases of this disease, one of them with a classic presentation of endometritis and the other one with a severe compromise in which the clinical presentation and imaging findings suggested a possible endometrial carcinoma. Knowledge of this unusual and rare pathology, including its etiopathogenesis, is important since it can be included in the differential diagnosis of endometrial carcinoma and, therefore, whenever it is found, to avoid excessive treatment.

show abstract

“…, Staphylococcus aureus , Bacteroides fragilis , Salmonella typhi , Actinomyces , Streptococcus faecalis , viridans streptococci , etc. 21 The pus culture is negative for acid-fast bacteria. The antibiotic therapy alone is not sufficient and operative treatment is necessary in the form of salpingo-oophorectomy, depending on the site of lesion.…”

Section: Discussionmentioning

confidence: 99%

“…The microscopic examination shows the presence of foamy histiocytes, along with a mixture of inflammatory cells like lymphocytes, plasma cells, and occasional neutrophils. 21 Foamy histiocytes, the so-called “xanthoma cells,” are histiocytes with abundant lipid-laden cytoplasm having a vacuolated appearance. These impart the yellowish color to the specimen, when seen on the gross examination.…”

Section: Discussionmentioning

confidence: 99%

“…2 In cases of endometriosis, sites of bleeding along with the obstruction remain to be the fertile soil for the growth of multitude of microorganisms, which is then followed by tissue necrosis and the subsequent release of cholesterol and other lipids, which further leads to increased number of tissue macrophages, trying to phagocytose these products. 21 It has been also considered by some that xanthogranulomatous oophoritis may be the rare aggressive form of the commonly occurring endometriosis.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Xanthogranulomatous Oophoritis in the Setting of Post-IVF Twin Pregnancy with History of Endometriosis: A Rare Case Report with Review of Literature

Pendharkar

B.S

Pendkur

et al. 2022

Indian J Med Paediatr Oncol

View full text Add to dashboard Cite

Xanthogranulomatous inflammation is an uncommon, nonneoplastic, chronic process in which the affected organ is destroyed by massive cellular infiltration of foamy histiocytes admixed with multinucleated giant cells, plasma cells, fibroblasts, neutrophils, and foci of necrosis. The organs most commonly affected by this entity are kidney and gallbladder. Only a few cases involving the ovary have been reported. The etiology of this entity is unknown, but the associated risk factors are infection, inappropriate antibiotic therapy, use of intrauterine contraceptive device, abnormalities in lipid metabolism, endometriosis, leiomyoma, and recurrent pelvic inflammatory disease. The current case was a 31-year-old female with post-in vitro fertilization (post-IVF) twin pregnancy, who presented with pain in the abdomen, provisionally diagnosed as ovarian mass with suspicion of malignancy. Patient was treated with antibiotics and an elective lower segment cesarean section was planned, due to lower abdominal pain and the presentation of both fetuses being breech. Patient underwent exploratory laparotomy with right oophorectomy and left double-J stenting, in view of left hydronephrosis. Diagnosis of xanthogranulomatous oophoritis was established on histopathological examination. There is only a single case; previously documented from India, in the setting of primary infertility. The present case report stresses that the condition may affect women of any age group and may be encountered in pregnancy, as has been observed in this case. Hence, thinking about this differential diagnosis in the cases presenting with similar complaints, would be of great value to avoid misdiagnosing them.

show abstract

Xanthogranulomatous Salpingitis and Oophoritis

Cited by 51 publications

References 23 publications

Exploring the Diagnostic Challenges of Uterine Lesions in Frozen Section: A Comprehensive Study at a Tertiary Care Center

Exploring the Diagnostic Challenges of Uterine Lesions in Frozen Section: A Comprehensive Study at a Tertiary Care Center

Xanthogranulomatous Endometritis: A Report of Two Cases

Xanthogranulomatous Oophoritis in the Setting of Post-IVF Twin Pregnancy with History of Endometriosis: A Rare Case Report with Review of Literature

Contact Info

Product

Resources

About