Xanthogranulomatous pancreatitis mimicking a malignant solid tumour

Atreyapurapu, Viswanath; Keshwani, Abhinav; Ramachandra, Lingadakai; Pai, Kanthilatha

doi:10.1136/bcr-2015-209934

Cited by 11 publications

(10 citation statements)

References 7 publications

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“…Kim et al [ 33 ] F/70y Belly pain, dyspepsia Uncinate Whipple Resolution – 18. Atreyapurapu et al [ 34 ] M/60y Belly pain, vomit Uncinate Whipple Resolution – 19. Antary et al [ 35 ] F/13mo Jaundice Head and uncinate Whipple Resolution – PPPD pylorus preserving pancreatoduodenectomy …”

Section: Discussionmentioning

confidence: 99%

Pancreatic involvement in Erdheim-Chester disease: a case report and review of the literature

Dai

Duan

et al. 2022

BMC Gastroenterol

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Background Erdheim-Chester disease (ECD) is a rare form of non-Langerhans cell histiocytosis characterized by infiltration of lipid-laden foamy macrophages within different tissues. Clinical manifestations of ECD are highly heterogeneous. Bone lesions are found in 80%-95% of patients, while extraosseous lesions usually involve the cardiovascular system, retroperitoneum, central nervous system (CNS), and skin. Pancreatic involvement in ECD has barely been reported. Case presentation A 29-year-old female initially presented with menoxenia, diabetes insipidus and diabetes mellitus. 18F-fluorodeoxyglucose positron emission tomography-computed tomography (18F-FDG-PET/CT) revealed hypermetabolic foci in the bilateral frontal lobe, saddle area, and pancreas. A 99mTc-MDP bone scrintigraphy scan revealed symmetrical increased uptake in distal femoral and proximal tibial metaphysis, which was confirmed to be osteosclerosis by high-resolution peripheral quantitative computed tomography. The patient underwent incomplete resection of the sellar mass. Histological examination of biopsies showed histiocytic aggregates, which were positive for S100 and negative for CD1a and CD207 on immunohistochemistry. Enhanced abdominal CT scan showed hypointense nodules within the body and tail of the pancreas. Endoscopic ultrasonography guided fine-needle aspiration (EUS-FNA) found no evidence of malignancy. She was diagnosed with ECD and treated with high-dose IFN-α. Repeated examinations at three-and eight-months post treatment revealed markedly reduction of both intracranial and pancreatic lesions. Conclusions ECD is a rare histiocytic neoplasm that can involve almost every organ, whereas pancreatic involvement has barely been reported to date. Here, we present the rare case of pancreatic lesions in ECD that responded well to interferon-α. We further reviewed reports of pancreatic involvement in histiocytic disorders and concluded the characteristics of such lesions to help diagnosis and treatment, in which these lesions mimicked pancreatic adenocarcinoma and caused unnecessary invasive surgeries.

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Section: Discussionmentioning

confidence: 99%

Pancreatic involvement in Erdheim-Chester disease: a case report and review of the literature

Dai

Duan

et al. 2022

BMC Gastroenterol

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“…IPMT Cystic PPPD 1.5 × 1 Kim et al [4] 70 Atreyapurapu et al [18] 60/M Abdominal pain India Head Normal Normal NA Heterogeneously NA Malignancy Solid WPD NA…”

Section: Case Presentationmentioning

confidence: 99%

Xanthogranulomatous pancreatitis combined with multifocal necrosis: A case report and literature review

Tang

Wenming

2020

International Journal of Surgery Oncology

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Xanthogranulomatous inflammation is rare and occurs in several viscera in the body, such as the kidney, gallbladder, bone, and stomach. The pathogenesis of Xanthogranulomatous pancreatitis (XGP) is not well understood, and the disease is characterized by lipid-laden histiocytes deposited at various sites in the organs. XGP associated with multifocal necrosis is extremely rare. In this report, we described a case of XGP associated with multifocal necrosis and included a review of the literature.

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“…Xanthogranulomatous lesions in the pancreas are rare, and most cases have been reported as xanthogranulomatous pancreatitis (1)(2)(3). To date, xanthogranulomatous pancreatitis associated with intraductal papillary mucinous neoplasm (IPMN) has been described in only a few reports (4)(5)(6).…”

Section: Introductionmentioning

confidence: 99%

Branch-duct Intraductal Papillary Mucinous Neoplasm with Rapidly Developing Intracystic Xanthogranulomatous Nodules

et al. 2023

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We herein report a case of a branch-duct intraductal papillary mucinous neoplasm (IPMN) with rapidly developing intracystic xanthogranulomatous nodules. A unilocular cystic lesion without a mural nodule was found in the pancreatic tail of a 69-year-old man. Ten months later, multiple mural nodules emerged unexpectedly within the cyst, and the patient underwent distal pancreatectomy. Based on immunohistochemical studies and a molecular analysis, we diagnosed him with branch-duct IPMN of the gastric immunophenotype. Fragility of the pancreatic duct mucosa and consequent exposure of the wall to pancreatic juice might have caused marked granulation nodule formation in the cyst lumen.

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Xanthogranulomatous pancreatitis mimicking a malignant solid tumour

Cited by 11 publications

References 7 publications

Pancreatic involvement in Erdheim-Chester disease: a case report and review of the literature

Pancreatic involvement in Erdheim-Chester disease: a case report and review of the literature

Xanthogranulomatous pancreatitis combined with multifocal necrosis: A case report and literature review

Branch-duct Intraductal Papillary Mucinous Neoplasm with Rapidly Developing Intracystic Xanthogranulomatous Nodules

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