Xanthogranuloma in adults

Abstract

Nine cases of cutaneous xanthogranuloma in adults are reported. These lesions were histologically indistinguishable from the xanthogranulomas in infants and children (juvenile xanthogranuloma), and, like those in the young, they were not associated with abnormalities of serum lipids. Unlike juvenile xanthogranuloma, however, in our small sample there was no concomitant involvement of the eye in adult xanthogranuloma.

Clinicohistopathologic Comparison of Adult Type and Juvenile Type Xanthogranulomas in Korea

“…Oncocytic cells were, in part, present both in AXGs and JXGs, and there was no significant difference. Spindle cell xanghogranuloma (SXG) and nodular histiocytois usually occur in adults (2, 9, 10, 16) but, in our study, spindle cells with or without vague storiform patterns, were observed in all cases, although the degree was variable. In all cases, inflammatory cells such as small lymphocytes, eosinophils, and polymorphonuclear cells were also shown in decreasing order.…”

“…Previous studies failed to reveal any evidence of ocular or systemic involvement of XGs in 9 adult patients (2–9). In JXGs, XG lesions have been detected in sites other than the skin and eyes, including the lung, gonads, pericardium, spleen, and kidney (11, 12, 17–21).…”

“…In addition, there were only minor differences such as solitary appearance, lesions, larger sizes, and absence of extensive subcutaneous involvement in AXGs as compared to JXGs. JXG can be distinguished into two clinical variants depending on the size and number of lesions: numerous, papular forms and a few large nodular forms (2, 11, 12). In adult cases, solitary and large nodular forms are known to be predominant (2–12).…”

“…JXG can be distinguished into two clinical variants depending on the size and number of lesions: numerous, papular forms and a few large nodular forms (2, 11, 12). In adult cases, solitary and large nodular forms are known to be predominant (2–12). Our study confirmed this tendency.…”

Adult onset xanthogranuloma – case report and review of literature

“…JXG lesions generally resolve spontaneously. However, this is not the case with adult xanthogranuloma (5,16).…”