Xanthogranuloma in adults

Rodriguez, J.

doi:10.1001/archderm.112.1.43

Cited by 42 publications

(30 citation statements)

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“…Thus, it does not require exhaustive investigations. Spontaneous involution seems more frequent than it was commonly believed [1, 4, 18] (54% vs. 83% in JXG), with a mean duration of 22 months; therefore, aggressive treatment should be avoided. The main differential diagnosis is with PX, which has the same clinical feature and evolution as AXG, occurring after young adolescence, in solitary or multiple form, with no extracutaneous localization except for mucosal involvement, and frequent spontaneous involution.…”

Section: Discussionmentioning

confidence: 99%

Multiple Adult Xanthogranuloma: Case Report and Literature Review

et al. 2006

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Background: Non-Langerhans cell histiocytoses form a heterogeneous group defined by the proliferation of cells with macrophage characteristics. Diagnosis is easy in typical cases but becomes more complex in unusual forms. Case Report: We report the case of a 53-year-old patient who presented multiple brown-to-yellowish papules and nodules of the trunk, neck, and head evolving for 6 months. No visceral involvement was found. Histopathological examination revealed histiocytic proliferation with features of secondary xanthomization with the presence of giant foamy multinucleated Touton cells. One year later, all lesions cleared spontaneously. Based on the clinical presentation and evolution and on the immunohistologic data, we retain the diagnosis of adult xanthogranuloma (AXG) in a diffuse shape. Discussion: Multiple AXG is a rare entity (15 cases reported since 1963) with a stereotypic presentation. It is important to recognize because of its good prognosis and the absence of visceral involvement therefore requiring no investigations or aggressive treatments. This case is interesting because of the complete and spontaneous healing of all the lesions within 20 months.

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Section: Discussionmentioning

confidence: 99%

Multiple Adult Xanthogranuloma: Case Report and Literature Review

et al. 2006

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“…Half of the cases of JXG have been reported in infants less than six months of age. (1) Approximately 10% of JXGs manifest in adulthood, and this form of JXG has been conveniently termed 'late-onset JXG' by some authors. (2) The present case report describes an unusual presentation of JXG in a 28-year-old man.…”

Section: Introductionmentioning

confidence: 99%

Unusual presentation of adult xanthogranuloma

Tan

2014

smedj

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Xanthogranulomas are the most common form of non-Langerhans cell histiocytosis. Both adult and childhood forms have been described. Adult cutaneous forms can present as solitary or multiple yellowish, orangered or tan-hued papules. Herein, we present the case of a 28-year-old Chinese man with a skin-coloured nodule on his left nasal ala that persisted for several months. While initial impression was that of a fibrous papule of the nose, the results of an excision biopsy showed histological features corresponding to xanthogranuloma. This case demonstrates the condition's myriad of dermatological presentations, and adds to the differential diagnoses of a cutaneous lesion found in the head and neck region.

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“…It is predominantly a disease of infancy or early childhood, although adults may infrequently be affected (adult xanthogranuloma) [1,2], the histological findings of both forms being indistinguishable [1,3]. The lesions are characterized clinically by unique or multiple yellow-red papulonodules that usually regress spontaneously in children and tend to persist in adult xanthogranuloma [4,5].…”

Section: Introductionmentioning

confidence: 99%

Adult Xanthogranuloma Mimicking Basal Cell Carcinoma: Dermoscopy, Reflectance Confocal Microscopy and Pathological Correlation

et al. 2009

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Juvenile xanthogranuloma in adulthood is an infrequent non-Langerhans cell histiocytosis, which may simulate malignant tumors such as basal cell carcinoma (BCC) or amelanotic melanoma. Dermoscopy has been described as a useful tool in the preoperative diagnosis of xanthogranuloma. We report a xanthogranuloma on the suprapubic area of a 48-year-old female, which clinically and dermoscopically mimicked a BCC with a yellowish hue and arborizing vessels. Reflectance confocal microscopy exhibited large highly refractive atypical cells in the dermis, some of them with pleomorphic nuclei, corresponding to Touton cells in the histopathological study. To our knowledge this is the first description of the clinical, dermoscopic and confocal microscopy correlations of a xanthogranuloma.

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Xanthogranuloma in adults

Cited by 42 publications

References 0 publications

Multiple Adult Xanthogranuloma: Case Report and Literature Review

Multiple Adult Xanthogranuloma: Case Report and Literature Review

Unusual presentation of adult xanthogranuloma

Adult Xanthogranuloma Mimicking Basal Cell Carcinoma: Dermoscopy, Reflectance Confocal Microscopy and Pathological Correlation

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