Xanthoangelol alleviates cerebral ischemia reperfusion injury in rats

Meng, Chao; Gao, Chao; Huang, Ya‐Ping

doi:10.1002/ar.24481

Cited by 6 publications

(3 citation statements)

References 23 publications

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“…Besides, xanthoangelol plays a role as an anticancer (Yang et al, 2019) and antibacterial agent (Inamori et al, 1991). Recently, in vivo and in vitro studies performed by Chao et al (2020) found that xanthoangelol could attenuate cerebral I/R injury by mitigating apoptosis through the remission of oxidative stress concomitant with Nrf2 activation (Chao et al, 2020).…”

Section: Effect Of Natural Chalcones On Different Types Of I/r Injurymentioning

confidence: 99%

The importance of natural chalcones in ischemic organ damage: Comprehensive and bioinformatic analysis review

Sayed

Gohar

Abd-alhameed

et al. 2022

Journal of Food Biochemistry

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Over the last few decades, extensive research has been conducted, yielding a detailed account of thousands of newly discovered compounds of natural origin and their biological activities, all of which have the potential to be used for a wide range of therapeutic purposes. There are multiple research papers denoting the central objective of chalcones, which have been shown to have therapeutic potential against various forms of ischemia. The various aspects of chalcones are discussed in this review regarding molecular mechanisms involved in the promising anti‐ischemic potential of these chalcones. The main mechanisms involved in these protective effects are Nrf2/Akt activation and NF‐κB/TLR4 suppression. Furthermore, in‐silico studies were carried out to discover the probable binding of these chalcones to Keap‐1 (an inhibitor of Nrf2), Akt, NF‐κB, and TLR4 protein molecules. Besides, network pharmacology analysis was conducted to predict the interacting partners of these signals. The obtained results indicated that Nrf2, Akt, NF‐κB, and TLR4 are involved in the beneficial anti‐ischemic actions of chalcones. Conclusively, the present findings show that chalcones as anti‐ischemic agents have a valid rationale. The discussed studies will provide a comprehensive viewpoint on chalcones and can help to optimize their effects in different ischemia. Practical applications Ischemic organ damage is an unavoidable pathological condition with a high worldwide incidence. According to the current research progress, natural chalcones have been proved to treat and/or prevent various types of ischemic organ damage by alleviating oxidative stress, inflammation, and apoptosis by different molecular mechanisms. This article displays the comprehensive research progress and the molecular basis of ischemic organ damage pathophysiology and introduces natural chalcones' mechanism in the ischemic organ condition.

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Section: Effect Of Natural Chalcones On Different Types Of I/r Injurymentioning

confidence: 99%

The importance of natural chalcones in ischemic organ damage: Comprehensive and bioinformatic analysis review

Sayed

Gohar

Abd-alhameed

et al. 2022

Journal of Food Biochemistry

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“…And researchers discovered that activating Nrf2 was the critical mechanism [ 70 ]. Xanthoangelol is an important ingredient of propolis, which triggered Nrf2 to treat ischemic stroke [ 71 ].…”

Section: Flavonoidmentioning

confidence: 99%

Role of Polyphenols as Antioxidant Supplementation in Ischemic Stroke

Zhou

Zhang

Fan

2021

Oxidative Medicine and Cellular Longevity

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Stroke is the second most common cause of death globally and the leading cause of death in China. The pathogenesis of cerebral ischemia injury is complex, and oxidative stress plays an important role in the fundamental pathologic progression of cerebral damage in ischemic stroke. Previous studies have preliminarily confirmed that oxidative stress should be a potential therapeutic target and antioxidant as a treatment strategy for ischemic stroke. Emerging experimental studies have demonstrated that polyphenols exert the antioxidant potential to play the neuroprotection role after ischemic stroke. This comprehensive review summarizes antioxidant effects of some polyphenols, which have the most inhibition effects on reactive oxygen species generation and oxidative stress after ischemic stroke.

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“…Prenylated chalcones have drawn increased attention in the fields of nutrition and cancer prevention because of their pharmacological effects, which have been thoroughly studied in vitro and in preclinical investigations [ 12 ]. Xanol is known to have protective effects against allergic diabetes, inflammation, infection, ischemia, neurodegeneration, muscle loss, oxidative stress, tumor growth, and tumor metastasis [ 6 , 7 , 13 , 14 ]. However, the pharmacological and molecular effects of xanol on OSCC have not yet been investigated.…”

Section: Introductionmentioning

confidence: 99%

Xanol Promotes Apoptosis and Autophagy and Inhibits Necroptosis and Metastasis via the Inhibition of AKT Signaling in Human Oral Squamous Cell Carcinoma

Yun

Kim

et al. 2023

Cells

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Angelica keiskei Koidzumi (A. keiskei) is used as a traditional medicine, anti-aging agent, and health food, as well as to restore vitality. Xanthoangelol (xanol), a prenylated chalcone, is the predominant constituent of A. keiskei. Oral squamous cell carcinoma (OSCC), the most common malignancy, has a high proliferation rate and frequent metastasis. However, it is unknown whether xanol has anti-OSCC effects on apoptosis, autophagy, and necroptosis. In the present study, we purified xanol from A. keiskei and demonstrated that it suppressed cell proliferation and induced cytotoxicity in human OSCC. Xanol triggered apoptotic cell death by regulating apoptotic machinery molecules but inhibited necroptotic cell death by dephosphorylating the necroptotic machinery molecules RIP1, RIP3, and MLKL in human OSCC. We also found that xanol inhibited the PI3K/AKT/mTOR/p70S6K pathway and induced autophagosome formation by enhancing beclin-1 and LC3 expression levels and reducing p62 expression levels. Furthermore, we showed that xanol prevented the metastatic phenotypes of human OSCC by inhibiting migration and invasion via the reduction of MMP13 and VEGF. Finally, we demonstrated that xanol exerted anticancer effects on tumorigenicity associated with its transformed properties. Taken together, these findings demonstrate the anticancer effects and biological mechanism of action of xanol as an effective phytomedicine for human OSCC.

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Xanthoangelol alleviates cerebral ischemia reperfusion injury in rats

Cited by 6 publications

References 23 publications

The importance of natural chalcones in ischemic organ damage: Comprehensive and bioinformatic analysis review

The importance of natural chalcones in ischemic organ damage: Comprehensive and bioinformatic analysis review

Role of Polyphenols as Antioxidant Supplementation in Ischemic Stroke

Xanol Promotes Apoptosis and Autophagy and Inhibits Necroptosis and Metastasis via the Inhibition of AKT Signaling in Human Oral Squamous Cell Carcinoma

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