Role of Polyphenols as Antioxidant Supplementation in Ischemic Stroke

Zhou, Yuan; Zhang, Shanshan; Fan, Xiang

doi:10.1155/2021/5471347

Cited by 29 publications

(20 citation statements)

References 159 publications

(160 reference statements)

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“…Dioscin could be hydrolyzed to diosgenin in mammalian body, and diosgenin could not be further metabolized ( Li et al, 2019 ). Traditional Chinese medicine provides direction for research on functional foods and natural products based on abundant clinical practices ( Zhou et al, 2021a ; Zhou et al, 2021b ). Yam, usually applied to treat digestive system diseases, reminds researchers of the potential function of diosgenin in metabolic disorders.…”

Section: Introductionmentioning

confidence: 99%

Diosgenin Ameliorates Non-alcoholic Fatty Liver Disease by Modulating the Gut Microbiota and Related Lipid/Amino Acid Metabolism in High Fat Diet-Fed Rats

Zhou

Zheng

et al. 2022

Front. Pharmacol.

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Non-alcoholic fatty liver disease (NAFLD) is a metabolic disease closely associated with dietary habits. Diosgenin is abundant in yam, a common food and traditional Chinese medicine. The molecular mechanism of diosgenin on NAFLD has been preliminarily explored. However, the effect of diosgenin on metabolism and gut microbiota in NAFLD has not been reported. This study confirmed that diosgenin could suppress excessive weight gain, reduce serum levels of total cholesterol and triglycerides, and decrease liver fat accumulation in high-fat diet-induced NAFLD rats. Moreover, fecal metabolomics analysis suggested diosgenin improved abnormal lipid and amino acid metabolism. Bile acids, including lithocholic acid and ursodeoxycholic acid 3-sulfate that function as excretion, absorption, and transport of fats, were remarkably regulated by diosgenin. Aromatic amino acid and lysine metabolism was regulated by diosgenin as well. 16S rRNA gene sequencing analysis demonstrated that diosgenin restored gut microbiota disorder, especially Globicatella, Phascolarctobacterium, Pseudochrobactrum, and uncultured_bacterium_f_Prevotellaceae at the genus level. Additionally, these regulated bacterial genera showed significant correlations with lipid and amino acid metabolism-related biomarkers. This study further confirmed the significant effect of diosgenin on NAFLD, and provided a new perspective for the mechanism.

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Section: Introductionmentioning

confidence: 99%

Diosgenin Ameliorates Non-alcoholic Fatty Liver Disease by Modulating the Gut Microbiota and Related Lipid/Amino Acid Metabolism in High Fat Diet-Fed Rats

Zhou

Zheng

et al. 2022

Front. Pharmacol.

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“…Clinical studies have shown that inflammation, excitatory toxicity, iron accumulation and oxidative stress occur during the onset of stroke [107]. The use of iron chelating agents, antioxidants, and free radical scavengers can reduce cerebrovascular damage after stroke [108,109]. Recent studies have found that hippocampal neurons in vitro stroke models and mouse cortical nerve cells after ischemia and reperfusion in vivo have the characteristics of ferroptosis, and the use of ferroptosis inhibitors can significantly reverse cell death [77,110].…”

Section: Strokementioning

confidence: 99%

Emerging Mechanisms and Targeted Therapy of Ferroptosis in Neurological Diseases and Neuro-oncology

Wang¹,

Tang²,

Zhu³

et al. 2022

Int. J. Biol. Sci.

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Ferroptosis is a novel type of cell death characterized by iron-dependent lipid peroxidation that involves a variety of biological processes, such as iron metabolism, lipid metabolism, and oxidative stress. A growing body of research suggests that ferroptosis is associated with cancer and neurodegenerative diseases, such as glioblastoma, Alzheimer's disease, Parkinson's disease, and stroke. Building on these findings, we can selectively induce ferroptosis for the treatment of certain cancers, or we can treat neurodegenerative diseases by inhibiting ferroptosis. This review summarizes the relevant advances in ferroptosis, the regulatory mechanisms of ferroptosis, the participation of ferroptosis in brain tumors and neurodegenerative diseases, and the corresponding drug therapies to provide new potential targets for its treatment.

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“…Natural polyphenols are mainly found in fruits and vegetables, nuts, soybeans, tea, cocoa, and alcohol. Polyphenols are known as “the seventh category of nutrients” and have antioxidant effects [ 91 ]. As shown in Table 1 , phenolic compounds could attenuate the oxidative stress caused by ICH.…”

Section: Targeted Therapy Of Oxidative Stress With Natural Productsmentioning

confidence: 99%

Targeting Oxidative Stress in Intracerebral Hemorrhage: Prospects of the Natural Products Approach

Zheng

Fan

2022

Antioxidants

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Intracerebral hemorrhage (ICH), the second most common subtype of stroke, remains a significant cause of morbidity and mortality worldwide. The pathological mechanism of ICH is very complex, and it has been demonstrated that oxidative stress (OS) plays an important role in the pathogenesis of ICH. Previous studies have shown that OS is a therapeutic target after ICH, and antioxidants have also achieved some benefits in the treatment of ICH. This review aimed to explore the promise of natural products therapy to target OS in ICH. We searched PubMed using the keywords “oxidative stress in intracerebral hemorrhage” and “natural products in intracerebral hemorrhage.” Numerous animal and cell studies on ICH have demonstrated the potent antioxidant properties of natural products, including polyphenols and phenolic compounds, terpenoids, alkaloids, etc. In summary, natural products such as antioxidants offer the possibility of treatment of OS after ICH. However, researchers still have a long way to go to apply these natural products for the treatment of ICH more widely in the clinic.

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Role of Polyphenols as Antioxidant Supplementation in Ischemic Stroke

Cited by 29 publications

References 159 publications

Diosgenin Ameliorates Non-alcoholic Fatty Liver Disease by Modulating the Gut Microbiota and Related Lipid/Amino Acid Metabolism in High Fat Diet-Fed Rats

Diosgenin Ameliorates Non-alcoholic Fatty Liver Disease by Modulating the Gut Microbiota and Related Lipid/Amino Acid Metabolism in High Fat Diet-Fed Rats

Emerging Mechanisms and Targeted Therapy of Ferroptosis in Neurological Diseases and Neuro-oncology

Targeting Oxidative Stress in Intracerebral Hemorrhage: Prospects of the Natural Products Approach

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