Targeting Oxidative Stress in Intracerebral Hemorrhage: Prospects of the Natural Products Approach

Zheng, Yingyi; Li, Ruoqi; Fan, Xiang

doi:10.3390/antiox11091811

Cited by 10 publications

(3 citation statements)

References 157 publications

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“…Pathophysiologically, a higher level of glucose fluctuation has been associated with the severity of systemic oxidative stress [35,36], which is considered as the key mechanism underlying the association between acute GV and cardiovascular complications in patients with diabetes. Interestingly, oxidative stress has been increasingly recognized as a key mechanism, which is responsible for the secondary brain injury in patients with ICH [37], probably via the induction the subsequent mechanisms involving inflammatory response, apoptosis, autophagy, and bloodbrain barrier disruption [38,39]. Therefore, it could be hypothesized that increased glucose fluctuation in patients with ICH may deteriorate the cerebral dysfunction by enhancing systemic oxidative stress inducing subsequent adverse molecular pathways, which may cause neural injury.…”

Section: Discussionmentioning

confidence: 99%

Glycemic Variability and Prognosis of Patients with Intracerebral Hemorrhage: A Meta-Analysis

Wang

et al. 2023

Horm Metab Res

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Glycemic disorder may affect the outcomes of patients with intracerebral hemorrhage (ICH). However, the association between glycemic variability (GV) and prognosis in these patients remains to be determined. We performed a meta-analysis to compressive the influence of GV on functional outcome and mortality in patients with ICH. Observational studies comparing the risks of poor functional outcome (defined as modified Rankin Scale>2) and all-cause mortality between ICH patients with higher versus lower acute GV were retrieved by systematic search of Medline, Web of Science, Embase, CNKI, and Wanfang databases. A random-effect model was used to pool the data after incorporating the between-study heterogeneity. Sensitivity analyses were performed to evaluate the stability of the findings. Eight cohort studies involving 3400 patients with ICH were included in the meta-analysis. The follow-up duration was within 3 months after admission. All of the included studies used standard deviation of blood glucose (SDBG) as the indicator of acute GV. Pooled results showed that ICH patients with higher SDBG were associated with a higher risk of poor functional outcome as compared to those with lower SDBG [risk ratio (RR): 1.84, 95% confidence interval (CI): 1.41 to 2.42, p<0.001, I2=0%]. In addition, patients with higher category of SDBG were also associated with a higher mortality risk (RR: 2.39, 95% CI: 1.79 to 3.19, p<0.001, I2=0%). In conclusion, high acute GV may be a predictor of poor functional outcome and mortality of patients with ICH.

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Section: Discussionmentioning

confidence: 99%

Glycemic Variability and Prognosis of Patients with Intracerebral Hemorrhage: A Meta-Analysis

Wang

et al. 2023

Horm Metab Res

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“…Primary damage occurs within the initial hours after the onset of bleeding, primarily driven by the mass effect of the hematoma ( 15 ). Secondary damage refers to a cascade of reactions resulting from primary injury and the release of blood clot components, including excitotoxicity ( 16 , 17 ), oxidative stress ( 18 , 19 ), neuroinflammation ( 16 , 18 , 20 , 21 ), disruption of the blood–brain barrier (BBB) ( 21 , 22 ), ultimately leading to neuronal cell death ( 18 , 23 ). Of these, neuroinflammation mainly involves early activation of resident microglia, release of pro-inflammatory mediators and influx of peripheral immune cells ( 24 , 25 ).…”

Section: Overview Of Hemorrhagic Strokementioning

confidence: 99%

Unveiling the significance of TREM1/2 in hemorrhagic stroke: structure, function, and therapeutic implications

Kong,

Wang,

Jin

et al. 2024

Front. Neurol.

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Stroke has long been a major threat to human health worldwide. Hemorrhagic stroke, including intracerebral hemorrhage and subarachnoid hemorrhage, exhibits a high incidence rate and a high mortality and disability rate, imposing a substantial burden on both public health and the economy and society. In recent years, the triggering receptor expressed on myeloid cells (TREM) family has garnered extensive attention in various pathological conditions, including hemorrhagic stroke. This review comprehensively summarizes the structure and function of TREM1/2, as well as their roles and potential mechanisms in hemorrhagic stroke, with the aim of providing guidance for the development of targeted therapeutic strategies in the future.

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“…Oxidative stress has been implicated in the pathogenesis of a variety of common diseases, including stroke, hypertension, diabetes, neurodegenerative diseases, and malignancies [ 3 , 4 , 5 ]. In the study of a variety of diseases, many natural products have been found to be effective in regulating oxidative stress and thus exert anti-cancer properties [ 6 ] and the ability to treat intracerebral hemorrhage [ 7 ], diabetes, and neurodegenerative diseases due to an excessive inflammatory response [ 8 ]. This may be due to the unique free-radical-scavenging effect of plant-derived natural products [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

A Review: Pharmacological Effect of Natural Compounds in Diospyros kaki Leaves from the Perspective of Oxidative Stress

Hong,

Wang,

et al. 2023

Molecules

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Oxidative stress is caused by an imbalance between reactive oxygen species and antioxidant levels. Current research suggests that oxidative stress is one of the key factors in the development of many chronic diseases, and it has been a concern for many years. Many natural compounds have been studied for their special free-radical-scavenging properties. The major chemical constituents of the leaves of Diospyros kaki are flavonoids and triterpenoids, both of which are potential antioxidants that can prevent damage caused by reactive oxygen species or reactive nitrogen species and ameliorate diseases associated with oxidative stress. In addition to the major constituents such as flavonoids and triterpenoids, the leaves of Diospyros kaki include compounds such as phenylpropanoids, alkaloids, phenolic acids, and terpenes. Studies have shown these compounds have certain antioxidant and neuroprotective activities. Experiments have shown that flavonoids or the extracts from the leaves of Diospyros kaki have a variety of good pharmacological activities, which could activate oxidative stress and mitochondrial apoptosis, inhibit the proliferation of human prostate cancer cells and induce apoptosis. It also could achieve the effect of anti-cancer cell proliferation and induce apoptosis by regulating oxidative stress. The main chemical substance of the leaves of Diospyros kaki regulating oxidative stress may be these multi-hydroxyl structure compounds. These natural products exhibit significant antioxidant activity and are an important basis for the leaves of Diospyros kaki to treat human diseases by regulating oxidative stress. This review summarizes the structural types of natural products in the leaves of Diospyros kaki and elaborates the mechanism of the leaves of Diospyros kaki in neuroprotection, anti-diabetes, renal protection, retinal degenerative diseases, and anti-cancer from a new perspective of oxidative stress, including how it supplements other pharmacological effects. The chemical constituents and pharmacological effects of the leaves of Diospyros kaki are summarized in this paper. The relationship between the chemical components in the leaves of Diospyros kaki and their pharmacological effects is summarized from the perspective of oxidative stress. This review provides a reference for the study of natural anti-oxidative stress drugs.

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Targeting Oxidative Stress in Intracerebral Hemorrhage: Prospects of the Natural Products Approach

Cited by 10 publications

References 157 publications

Glycemic Variability and Prognosis of Patients with Intracerebral Hemorrhage: A Meta-Analysis

Glycemic Variability and Prognosis of Patients with Intracerebral Hemorrhage: A Meta-Analysis

Unveiling the significance of TREM1/2 in hemorrhagic stroke: structure, function, and therapeutic implications

A Review: Pharmacological Effect of Natural Compounds in Diospyros kaki Leaves from the Perspective of Oxidative Stress

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