Xanthinin: a Plant Growth-regulating Compound from Xanthium pennsylvanicum. I

Optimization of xanthatin extraction from Xanthium spinosum L. and its cytotoxic, anti-angiogenesis and antiviral properties

“…2). All the analytical data were verified by the comparison with these reported in the literature [4,15]. From the structural evidence, the main compound isolated was identified as xanthatin (2).…”

“…The structure was established by spectral methods and confirmed by X-ray diffraction. Analytical data was also compared with the bibliographic reported data [4].…”

“…Extracts from X. spinosum L. contain a mixture of compounds such as: b-sitosterol, quercetin and other flavonoids such as pendulin, iocein, centaurin and patuletin 3-O-glucoside [3]. Moreover, it contains xanthanolide sesquiterpene lactones such as: xanthinin (1), xanthatin (2), stizolicin (3) and solstitialin (4) [4] (Fig. 1).…”

“…solstitialin (4) were tested for antitumor action in vitro on two types of tumors: L-1210 leukemia and P-388 leukemia [7].…”

“…1). Xanthatin (2) was first isolated from Xanthium pennsylvanicum by J. E. Little and co-workers [14] and its structure was established by Geissman et al [4,15]. The latter group suggested the possibility that xanthatin could be formed from xanthinin by dehydration during isolation, particularly during purification by column chromatography.…”