Xanthine oxidase inhibitors from the leaves of Lagerstroemia speciosa (L.) Pers.

Unno, Toshihiro; Sugimoto, Akio; Kakuda, Takami

doi:10.1016/j.jep.2004.04.012

Cited by 118 publications

(79 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Xanthine oxidase activity was measured spectrophotometrically at 295 nm under aerobic conditions. 25) Xanthine oxidases (50 mU/mL) of bovine or rat origin were incubated with test substrate samples at 25°C for 15 min and then incubated with 100 μM xanthine as the substrate at 25°C for 15 min. The reactions were stopped by the addition of 1 N HCl.…”

Section: Preparation Of Cfo Cfo (Kaneka Chrysflavonementioning

confidence: 99%

Administered chrysanthemum flower oil attenuates hyperuricemia: mechanism of action as revealed by DNA microarray analysis

Honda

Kawamoto

Tanaka

et al. 2014

Bioscience, Biotechnology, and Biochemistry

View full text Add to dashboard Cite

show abstract

Section: Preparation Of Cfo Cfo (Kaneka Chrysflavonementioning

confidence: 99%

Administered chrysanthemum flower oil attenuates hyperuricemia: mechanism of action as revealed by DNA microarray analysis

Honda

Kawamoto

Tanaka

et al. 2014

Bioscience, Biotechnology, and Biochemistry

View full text Add to dashboard Cite

show abstract

“…1,2-Naphthoquinone -6.14 -6.14 -6. Compound An increase in xanthine oxidase activity leads to an increase in the uric acid level, causing renal stone formation, ischemic myocardial infarction and free radical mediated diseases (Unno et al, 2004). Recent findings suggest that the occurrence of gout is increasing worldwide, possibly due to intake of foods rich in nucleic acid, such as organ meats and some types of sea food.…”

Section: Binding Energy = a + B + C -Dmentioning

confidence: 99%

Study of potential xanthine oxidase inhibitors: In silico and in vitro biological activity

Umamaheswari

Madeswaran

Asokkumar

et al. 2011

Bangladesh J Pharmacol

View full text Add to dashboard Cite

In an attempt to develop potent anti gout agents, coumarin derivatives and polyphenolic compounds were selected for present study. The docking energy of 2-benzyl coumarin was found to be -7.50 kcal/mol which was less than that of the standard allopurinol (-4.47 kcal/mol). All the selected compounds were found to exhibit lower binding energy (-7.50 to -4.68 kcal/mol) than allopurinol. Docking results confirm that selected compounds showed greater inhibition of xanthine oxidase due to their active binding sites. In xanthine oxidase assay, IC50 value of 2-benzyl coumarin was found to be 26 ± 1.16 µg/ mL, whereas that of allopurinol was 24 ± 0.28 µg/mL. All the compounds exhibited IC50 values ranging between 26 ± 1.16 to 58 ± 0.74 µg/mL. In enzyme kinetic studies, coumarin derivatives showed competitive and polyphenolic compounds showed non competitive type of enzyme inhibition. It can be concluded that coumarin derivatives could be a remedy for the treatment of gout and related inflammatory disorders. Article Info

show abstract

“…Gout is an inflammatory joint disease, associated with an elevated uric acid level in blood which further leads to the deposition of urate crystals in the joints and kidneys followed by painful inflammation, gouty arthritis, and uric acid nephrolithiasis [1][2][3]. Xanthine oxidase (XO) is responsible for oxidation of hypoxanthine to xanthine and finally xanthine to uric acid [4,5].…”

Section: Introductionmentioning

confidence: 99%

Indian Medicinal Plants Useful in Treatment of Gout: A Review for Current Status and Future Prospective

Kapoor

Kaur

Gupta

et al. 2017

Asian J Pharm Clin Res

View full text Add to dashboard Cite

Objective: The objective of this review is to collect and document information on the Indian medicinal plants with anti-gout potential.Methods: Bibliographic investigation was carried out by consulting worldwide scientific databases, analyzing Ayurvedic text books and research journals. The search terms were "gout," "uric acid," "hyperuricemia," "xanthine oxidase (XO) inhibitor and uricosuric." Herbal keywords included "herbal medicine," "medicinal plant," "natural products," "phytomedicine" and "phytotherapy." Result and Conclusion:Medicinal plants have been used to treat various ailments since ancient times; hence, ethnobotanical investigations play an important role in pharmacological studies. In India, traditional medicines are being practiced for the treatment of gout and other rheumatic disorders from ancient time. This review provides a comprehensive summary of 130 Indian plants which have been mentioned in ancient literature or used traditionally for the treatment of gout. Out of these, 41 plants have been reported to possess XO inhibitory activity. Further, isolated phytoconstituents having promising XO inhibitor activity are also included in this review. Although a variety of medicinal plants with anti-gout potential have been found in the literature, there is limited information on evaluation of anti-gout activity of isolated phytoconstituents. The current review contains a detailed discussion of the potential of medicinal plants for treatment of gout.

show abstract

Xanthine oxidase inhibitors from the leaves of Lagerstroemia speciosa (L.) Pers.

Cited by 118 publications

References 18 publications

Administered chrysanthemum flower oil attenuates hyperuricemia: mechanism of action as revealed by DNA microarray analysis

Administered chrysanthemum flower oil attenuates hyperuricemia: mechanism of action as revealed by DNA microarray analysis

Study of potential xanthine oxidase inhibitors: In silico and in vitro biological activity

Indian Medicinal Plants Useful in Treatment of Gout: A Review for Current Status and Future Prospective

Contact Info

Product

Resources

About