Xanthelasma palpebrarum and its relation to atherosclerotic risk factors and lipoprotein (a)

Abstract

In patients with xanthelasma, no increase was observed in the rate or risk of cardiovascular disease. Moreover, no relationship was found between Lp (a) levels and xanthelasma.

Xanthelasma palpebrarum: a marker of premature atherosclerosis (risk of atherosclerosis in xanthelasma)

“…Increased LDL-C and reduced HDL-C have also been implicated in the causation of atherosclerosis and CVD 10. The presence of a family history in 27.5% in the present series is comparable with 29% and 22% reported by Gomez et al 25 and Ozdol et al ,26 respectively, and suggests that genetic factors may contribute to the pathogenesis of XP.…”

“…Contrary to this, Gomez et al 25 and Segal et al 32 concluded that XP did not increase the risk of CVD. Recently in a case–control study of 100 patients with XP, Ozdol et al 26 reported similar rates of clinically overt CVD and future cardiovascular risk as evaluated by the prevalence of cardiac risk factors and Framingham risk scores. The variable outcome may be attributed to the lack of appropriate selection of control groups and small study populations in some of the above studies.…”

The Significance of Extracellular Cholesterol Crystals or a Cholesterol Granuloma in Xanthelasma

“…Xanthelasma has been studied as a marker of premature atherosclerosis by discovering ultrasonographic thickening of the carotid intima [22]. Defects in lipoproteins, apolipoproteins (proteins that bind lipids and transport them through the lymphatic and circulatory systems), apoenzymes, and vascular permeability in the face of normal serum lipid levels are other possible contributing mechanisms for the genesis of xanthelasma [23-25]. In a recent study [26], immunohistochemical staining of paraffin sections of xanthelasmas revealed a wide range of upregulated inflammatory cofactors paralleling those found in the early stages of cardiac atherosclerotic plaque formation.…”

Neurotization in brachial plexus injury – A 3 year experience in tertiary government institution

“…Though the exact cause is not known, disturbance in lipid metabolism may contribute to its pathogenesis. 2 XP appears as soft, velvety skin to yellow coloured macular, maculopapular and plaque like lesions over eyelids and around eyes. 3 Microscopically, XP is composed of foamy cells in the superficial dermis, where lipid-laden histiocytes can be seen.…”