Xanthan Gum a Versatile Biopolymer: Current Status and Future Prospectus in Hydro Gel Drug Delivery

Verma, Vinay Sagar; Sakure, Kalyani; Badwaik, Hemant

doi:10.2174/2212796810666161110152815

Cited by 20 publications

(3 citation statements)

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“…Analyzing the absorbance at 424 nm, the amount of Curcumin contained in the extract was determined using the calibration curve technique (Verma et al 2017).…”

Section: Analysis Uv Visible Spectroscopy May Be Used To Estimate The...mentioning

confidence: 99%

Extraction, isolation and quantification of curcumin for possible diabetis treatment

Panda

Das

2022

ijhs

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Anti-HIV, anti-tumor, anti-viral, anti-cancer, anti-fungal, and ant-parasitic properties of curcumin make it an important active ingredient in many medicines. High-purity curcumin can be obtained using a new extraction method. Increases in production were noticeable. This method of isolation and quantification had a low barrier to entry and was quick to execute. Curcumin was extracted using a soxhlet extraction experiment in this study. Diabetes Mellitus research and development can benefit from high-purity curcumin isolates. Analytical tools currently being developed can also play a significant role in the future quantification of novel dosage forms.

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“…Analyzing the absorbance at 424 nm, the amount of Curcumin contained in the extract was determined using the calibration curve technique (Verma et al 2017).…”

Section: Analysis Uv Visible Spectroscopy May Be Used To Estimate The...mentioning

confidence: 99%

Extraction, isolation and quantification of curcumin for possible diabetis treatment

Panda

Das

2022

ijhs

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“…[6,7] In the present study, the multiparticulates system based on ionic gelations were prepared using natural matrix chitosan and pectin polymers. [8][9][10][11][12] Perhaps in this study it was approached to display both the in vitro and in vivo correlations, while at the same time tried to justify the reasons behind modified mechanical and release retardant properties of the developed systems. Conventional formulation containing 5-fluorouracil (5FU) was suffering from problems of severe side effects due its rapid absorption and metabolism at the upper gastrointestinal (GI) tract, due to which a delayed release system is presently designed for management of colorectal cancer.…”

Section: Original Articlementioning

confidence: 99%

Untitled

Lanjhiyana¹

2021

AJP

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Objective: The present study aimed to develop sustained released 5-fluorouracil loaded chitosan-pectin blended dual cross-linked gel beads system. Materials and Methods: Dual cross-linked beads were evaluated for drug content, particle size, swelling degree, scanning elecron microscopy, differential scanning calorimetry, X-ray diffraction, etc., for its suitability for colon targeting. Results: The developed systems were appreciably performed during in vitro drug releases in simulated gastric (simulated gastric fluid) at pH 1.2, intestinal (simulated intestinal fluid) at pH 6.8, and colonic fluids at pH 7.4 (simulated colonic fluid [SCF]) with and without rat cecal content medium for up to 24 h. Batch formulations were shown lesser releases in acidic dissolution medium, whereas augmented releases in alkaline medium at the end of 24 h studies. It was found with significant drug releases (P > 0.05) in SCF containing 2 and 4% w/v rat cecal as compared to control studies. During curve fittings using several models, the R 2 value of Higuchi matrix model confirmed for drug release was followed with anomalous non-Fickian transport mechanisms. Those dual cross-linked gel beads confirmed for its improved mechanical core strength, controlled, and sustained release potentials during the experimental. Gamma scintigraphic imaging during in vivo studies confirms for targeting potential of optimized formulations for colon-specific region. It was evident that the ionic gelation based dual cross-linked chitosan-pectin beads with divalents Ca 2+ and SO 4 -2 ions exhibited better delayed drug release pattern than single cross-linked beads for colon targeting. Conclusion: The prepared dual ionic cross-linked optimized formulations may be potential system for targeting drug to colon for colorectal cancer.

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“…Synergistic interaction gels could be formed by mixing two types of polysaccharide that cannot form true gels on their own (Agoub, Smith, Giannouli, Richardson, & Morris, 2007;Williams, Day, Langdon, Phillips, & Nishinari, 1991), which have gained increasing interest as 3D printing materials (García-Segovia, García-Alcaraz, Balasch-Parisi, & Martínez-Monzó, 2020), slow release or delivery systems (S. Verma, Sakure, & R. Badwaik, 2017;Tu, Shi, Li, Wang, Qiao, Jiang, et al, 2022), and texture enhancer (Han, Long, Zhang, Dong, & Yan, 2022). It has been pointed out that xanthan and konjac glucomannan (KGM) are such typical polysaccharide sets, by mixing which the KGM/xanthan synergistic interaction gels could be formed (Goycoolea, Richardson, Morris, & Gidley, 1995;Yang, Li, Li, Li, Li, Sun, et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Evolutions of synergistic binding between konjac glucomannan and xanthan with high pyruvate group content induced by monovalent and divalent cation concentration

Qiao,

Luo,

et al. 2024

Food Chemistry

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Xanthan Gum a Versatile Biopolymer: Current Status and Future Prospectus in Hydro Gel Drug Delivery

Cited by 20 publications

References 0 publications

Extraction, isolation and quantification of curcumin for possible diabetis treatment

Extraction, isolation and quantification of curcumin for possible diabetis treatment

Untitled

Evolutions of synergistic binding between konjac glucomannan and xanthan with high pyruvate group content induced by monovalent and divalent cation concentration

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