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Abstract

A relationship between enteric microbiocenosis and severity of type 1 diabetes mellitus was detected. Microbiological analysis showed II-IV degree dysbacteriosis in all diabetic children. Long-term therapy with probiotics aimed at eradication of opportunistic microflora resulted in recovery of microbiocenosis, which was paralleled by improvement of the clinical status, regression of complications in children who were ill for a long time, and prevention of complications in children with newly detected diabetes. These results indicate the leading role of chronic enteric toxic infectious process in the development of complications of type 1 diabetes. The significance of infection in the pathogenesis of other noninfectious diseases in man is discussed.

Is there any association between gut microbiota and type 1 diabetes? A systematic review

“…We reviewed 26 articles, twenty-four of them approved a straight correlation between microbiota and diabetes; however, most of them didn’t clarify if microbiota induces T1D or T1D changes gut microbiome. The articles were screened according to the type of gut microbiota and correlation with T1D as explained below: one article mentioned that microbiome alteration occurs after diabetes [26], two articles studied microbiota as a therapeutic agent on T1D [35, 41], seven articles just showed the differences in gut microbiota of healthy and diabetic people and didn’t discuss the type of relation [21, 24, 29, 32, 34, 36, 40], finally fourteen articles suggested the exact mechanism that leads to autoimmunity by the change in gut microbiome [5, 18, 25, 27, 28, 31, 33, 37, 39, 42–46] (one article was just in the abstract form and we couldn’t read the details [30]).…”

Systematic Review of the Effect of Enteral Feeding on Gut Microbiota in Preterm Infants

“…The alteration or imbalance of microbiota, also named dysbiosis or dysbacteriosis, can disrupt human wellness, particularly among vulnerable infants born prematurely (<37 weeks gestational age). Dysbacteriosis was associated with increased risk of colic (Kianifar et al, 2014) and necrotizing enterocolitis (NEC) in preterm infants (Thomas, 2016; Warner et al, 2016) and can lead to immune disorders (e.g., inflammatory bowel disease; Burcelin, 2016; Jiang et al, 2015; Marteau, 2009), diabetes (Rozanova, Voevodin, Stenina, & Kushnareva, 2002), obesity (Menni et al, 2017; Turnbaugh et al, 2009), and cancer (Loo et al, 2017; Yamamoto & Matsumoto, 2016; Zhu, Gao, Wu, & Qin, 2013) later in life. Preterm infants, especially very low birth weight (VLBW) infants, are susceptible to imbalanced gut microbial community due to gut immaturity (Groer et al, 2014).…”