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Synthesis of cyano derivatives of pyrimidine bases and their effect on blood leukocyte system

“…The results of analysis of the possible mechanisms leading to a significant increase in the number of eosinophils in response to the administration of cyano derivatives of uracil and thymine do not exclude the manifestation of allergenic properties of cyans [10,11]. However, in combination with the increase in the number of band neutrophils, the growth in the number of eosinophils is indicative of the total activation of leukopoiesis, rather than of a selective effect [12,13].…”

Synthesis and chemical transformations of mono- and disubstituted cyanamides

“…Analysis of vast experimental data showed that alkyl radicals form the following series with respect to the ease of their departure as alkyl halide: allyl > benzyl > methyl > ethyl, etc. [22,23].…”

“…When a disubstituted cyanamide is available via reaction of cyanogen bromide with both secondary and tertiary amine, the Braun reaction is usually preferred, for it ensures a considerably better yield of the product. Purygin and co-workers synthesized 1-cyanobenzimidazole by the Braun reaction [23]. However, high toxicity of cyanogen halides strongly restricts their wide application in the synthesis of cyanamides.…”

Baker’s Yeast-Mediated Regioselective Reduction of 2,4-Dinitroacylanilines: Synthesis of 2-Substituted 6-Nitrobenzimidazoles

“…The class of heterocyclic compounds known as benzimidazoles show a variety of biological activities. For example, 2-substituted 5(6)-nitrobenzimidazoles and their derivatives have been studied for their analgesic, anti-inflammatory, anti-proliferative and anti-viral activity, 4 they have also been used as substrates for DT-diaphorase, 5 as starting materials for the synthesis of anti-viral and erythrocyte resistance compounds, 6,7 as well as intermediates for the preparation of potentially bioactive benzimidazoles. 8 Besides, nitrobenzimidazoles are employed as precursors for dye manufacturing and have showed promising applications in nonlinear optics.…”